The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma

Objectives: Multiple myeloma (MM) is characterized by the occurrence of osteolytic lesions. MM treatment usually involves antiresorptive drugs (mainly bisphosphonates). Case Report: A patient with an MM presented osteolytic lesions of the mandible. Extraction of teeth 45 and 46 was performed 5 years after the diagnosis of periodontitis. Four months later, osteonecrosis of the jaw (ONJ) was diagnosed at the extraction site. X-ray showed an extension of osteolytic lesions on the right side, close to the extraction site, without modification of the lesions on the left side. Two months later, a curettage was performed because of a painful bone sequestration. X-ray showed an extension of the osteolytic lesions on the right side. Results: Histological analysis found a vascularized plasmacytoma of the soft tissues around the ONJ. Analysis of the bone showed mixed lesions with osteonecrotic areas and living bone resorbed by active osteoclasts surrounding a plasmacytoma. The surface area of the osteolytic foci has considerably increased only close to the extraction site. Conclusions: Tooth extraction triggered an ONJ associated with bisphosphonate treatment. However, it also seemed to induce a considerable proliferation of plasma cells at the extraction site; we hypothesize that it is due to the increase in bone remodeling related to the surgical trauma.

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Extramedullar plasmocytoma of the oral cavity

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2020025 ◽

2020 ◽

Vol 26 (4) ◽

pp. 40

Author(s):

Helen Olugbeje ◽

Arthur Fourcade

Keyword(s):

Multiple Myeloma ◽

Differential Diagnosis ◽

Oral Cavity ◽

Histological Examination ◽

Plasma Cell ◽

Soft Tissues ◽

Cell Disease ◽

X Ray ◽

The Right

Introduction: Extramedullar plasmocytoma (EMP) is a plasma cell disease, such as solitary plasmocytoma of the bone and multiple myeloma. It is developed in the soft tissues. Observation: A 79-year-old patient consulted for a painful tumefaction of the gum associated to a radiolucent area on the right side of the mandible on the panoramic x-ray. After surgical enucleation, histological examination showed that the diagnosis was either an IgA extramedullar plasmocytoma or a multiple myeloma. The spreading assessment eliminated the diagnosis of multiple myeloma. The patient was then treated with radiotherapy. Discussion: EMP is a rare tumoral disease. Few cases described oral localisation. The main differential diagnosis, that must be excluded is multiple myeloma. Transformation in multiple myeloma exists. The first intention treatment is radiotherapy of the lesion. Conclusion: EMP of the oral cavity is very rare. After treatment, follow-up is required to detect second localisation or progression in multiple myeloma.

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Gallium nitrate in multiple myeloma: Prolonged survival in a cohort of patients with advanced-stage disease

Seminars in Oncology ◽

10.1016/s0093-7754(03)00172-6 ◽

2003 ◽

Vol 30 (2 Suppl 5) ◽

pp. 20-24 ◽

Cited By ~ 13

Author(s):

Ruben Niesvizky

Keyword(s):

Multiple Myeloma ◽

Prolonged Survival ◽

Gallium Nitrate ◽

Advanced Stage ◽

Stage Disease

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Ovarian epithelioid angiosarcoma complicating pregnancy: a case report and review of the literature

Journal of International Medical Research ◽

10.1177/03000605211019641 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110196

Author(s):

Xiaotong Peng ◽

Zhi Duan ◽

Hongling Yin ◽

Furong Dai ◽

Huining Liu

Keyword(s):

Adverse Events ◽

Soft Tissues ◽

Malignant Tumors ◽

Cystic Teratoma ◽

Abdominal Distension ◽

Epithelioid Angiosarcoma ◽

History Of ◽

New Ideas ◽

The Right ◽

Clinical Awareness

Epithelioid angiosarcoma is a rare and highly aggressive soft tissue angiosarcoma most commonly arising in the deep soft tissues. Given that abundant vascular cavities anastomose with each other, most angiosarcomas prone to metastasis recur quickly, and the overall prognosis is poor. We report a 25-year-old woman at 24 weeks’ gestation who presented with a 1-month history of abdominal distension. Ultrasonography suggested a mass in the right adnexa, and she underwent two operations owing to uncontrolled intraperitoneal bleeding with progressive anemia. The right ovarian tumor and right adnexa were removed successively. Biopsy yielded a diagnosis of primary epithelioid angiosarcoma with mature cystic teratoma. The patient died from uncontrolled progressive bleeding 1 week after the second operation. This case revealed that epithelial angiosarcoma is a highly malignant endothelial cell tumor. The results of surgery and chemoradiotherapy tend to be poor, and the recurrence rate is high. The purpose of this study is to raise clinical awareness of epithelial angiosarcoma and its adverse events and to provide new ideas for the treatment of these adverse events. Immunohistochemical staining of pathological specimens can facilitate diagnosis. Pregnancy with malignant tumors may lead to rapid disease progression, extensive lesions, and a poor prognosis.

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Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

Case Reports in Urology ◽

10.1155/2015/469327 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Tapan Kumar Sahoo ◽

Saroj Kumar Das ◽

Chandraprava Mishra ◽

Ipsita Dhal ◽

Rohani Nayak ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Radical Nephrectomy ◽

Advanced Stage ◽

Rare Entity ◽

Primary Squamous Cell Carcinoma ◽

Review Of The Literature ◽

Radiological Features ◽

The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

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Primitive Neuroectodermal Tumor of the Liver: A Case Report

Case Reports in Medicine ◽

10.1155/2011/748194 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 8

Author(s):

Eduardo Cambruzzi ◽

Enilde Eloena Guerra ◽

Hamilton Cardoso Hilgert ◽

Herbert Jorge Schmitz ◽

Vinícius Lopes Silva ◽

...

Keyword(s):

Primitive Neuroectodermal Tumor ◽

Soft Tissues ◽

Young Patients ◽

Neuroectodermal Tumor ◽

Solid Mass ◽

Resected Liver ◽

The Central Nervous System ◽

Right Lobe ◽

Upper Abdominal ◽

The Right

Primary liver sarcomas represent a rare group of neoplasias, with angiosarcoma being the most common histological type. Primitive neuroectodermal tumor (PNET) represents a high malignant neoplasia that usually affects the central nervous system and soft tissues. An 18-year-old male patient was admitted with clinical complains of pain in the right upper abdominal quadrant. The clinical evaluation revealed a solid mass in the right hepatic lobe. On the gross examination of the resected liver specimen, the right lobe of the liver was replaced by a yellow-red solid mass measuring 21 cm in its largest dimension. On the histopathology, a tumor composed of small round blue cells with little cytoplasm and round nuclei was identified. The lesion revealed positive immunoexpression for vimentin and CD99 and negative immunostaining for desmin, CD45, cytokeratin, and neuroblastoma protein, suggesting, then, the diagnosis of PNET. Although it is an unusual tumor, it should be considered in the differential diagnosis of liver masses, especially in young patients.

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NECROTISING SOFT TISSUE INFECTION OF BILATERAL UPPER LIMB CAUSED BY THE INJECTION OF ORAL BACTERIA: A CASE REPORT

Hand Surgery ◽

10.1142/s021881041372012x ◽

2013 ◽

Vol 18 (02) ◽

pp. 243-246 ◽

Cited By ~ 1

Author(s):

Yuichi Yoshii ◽

Tomoo Ishii ◽

Shinsuke Sakai

Keyword(s):

Soft Tissue ◽

Upper Limb ◽

Soft Tissue Infection ◽

Soft Tissues ◽

Biceps Brachii ◽

Subcutaneous Tissue ◽

Oral Bacteria ◽

Tissue Infection ◽

Left Elbow ◽

The Right

Necrotising soft tissue infection is a rare and rapid process with devastating consequence. We report one case of necrotising soft tissue infection in a bilateral upper limb with uncommon oral bacteria. Radiological imaging revealed the presence of gas in upper limb soft tissues, and an MRI showed the localised signal changes in the biceps muscle of the right upper arm, and the subcutaneous tissue of the left elbow. The patient was treated with surgical resection of the infected muscle and wide debridement of the subcutaneous tissue. Antibiotics were initiated. The patient recovered immediately without functional deficit. The unique features of this patient were possible to observe in the progression of the necrotising soft tissue infection in the bilateral upper limb with intentional injection of oral bacteria, and the effect of biceps brachii resection in a prime age worker.

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Solitary Plasmacytoma in the Mandible Resembling an Odontogenic Cyst/Tumor

Case Reports in Dentistry ◽

10.1155/2016/3629047 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Fatemeh Rezaei ◽

Hesamedin Nazari ◽

Babak Izadi

Keyword(s):

Multiple Myeloma ◽

Third Molar ◽

Panoramic Radiograph ◽

Final Diagnosis ◽

Chief Complaint ◽

Solitary Plasmacytoma ◽

Oral Medicine ◽

Bony Lesion ◽

The Right ◽

Rule Out

A 46-year-old male patient referred to Department of Oral Medicine, with the primary chief complaint of a painless swelling in the right side of mandibular. A panoramic radiograph revealed a well-defined, multilocular radiolucent bony lesion with thin and straight septa in the right side of mandible extending from distal of canine to mesial of third molar. Histological examination showed a solid proliferation of atypical plasmacytoid cells, which was indicative of plasmacytoma. A systemic workup for the final diagnosis was performed to rule out multiple myeloma.

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Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489418808541 ◽

2018 ◽

Vol 128 (2) ◽

pp. 152-156 ◽

Cited By ~ 2

Author(s):

Adam McCann ◽

Sameer A. Alvi ◽

Jessica Newman ◽

Kiran Kakarala ◽

Hinrich Staecker ◽

...

Keyword(s):

Soft Tissue ◽

Skull Base ◽

Temporal Bone ◽

Soft Tissues ◽

Trauma Surgery ◽

Oral Antibiotic ◽

Facial Skeleton ◽

Atypical Form ◽

Unsuccessful Treatment ◽

The Right

Background: Cervicofacial actinomycosis is an uncommon indolent infection caused by Actinomyces spp that typically affects individuals with innate or adaptive immunodeficiencies. Soft tissues of the face and neck are most commonly involved. Actinomyces osteomyelitis is uncommon; involvement of the skull base and temporal bone is exceedingly rare. The authors present a unique case of refractory cervicofacial actinomycosis with development of skull base and temporal bone osteomyelitis in an otherwise healthy individual. Methods: Case report with literature review. Results: A 69-year-old man presented with a soft tissue infection, culture positive for Actinomyces, over the right maxilla. Previous unsuccessful treatment included local debridement and 6 weeks of intravenous ceftriaxone. He was subsequently treated with conservative debridement and a prolonged course of intravenous followed by oral antibiotic. However, he eventually required multiple procedures, including maxillectomy, pterygopalatine fossa debridement, and a radical mastoidectomy to clear his disease. Postoperatively he was gradually transitioned off intravenous antibiotics. Conclusions: Cervicofacial actinomycosis involves soft tissue surrounding the facial skeleton and oral cavity and is typically associated with a history of mucosal trauma, surgery, or immunodeficiency. The patient was appropriately treated but experienced disease progression and escalation of therapy. Although actinomycosis is typically not an aggressive bacterial infection, this case illustrates the need for prompt recognition of persistent disease and earlier surgical intervention in cases of recalcitrant cervicofacial actinomycosis. Chronic actinomycosis has the potential for significant morbidity.

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Mandibular Bone and Soft Tissues Necrosis Caused by an Arsenical Endodontic Preparation Treated with Piezoelectric Device

Case Reports in Dentistry ◽

10.1155/2013/723753 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

A. Giudice ◽

M. G. Cristofaro ◽

I. Barca ◽

D. Novembre ◽

M. Giudice

Keyword(s):

Soft Tissues ◽

Mandibular Bone ◽

Bone Necrosis ◽

Second Molar ◽

Piezoelectric Device ◽

The Right

This paper describes a case of wide mandibular bone necrosis associated with significant soft tissues injury after using an arsenical endodontic preparation in the right lower second molar for endodontic purpose. Authors debate about the hazardous effects of the arsenic paste and the usefulness of piezosurgery for treatment of this drug related bone necrosis.

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