144 Recurrent Hematuria and Rhabdomyolysis in a Young Male with Medullary Sponge Kidney

doi:10.1053/j.ajkd.2020.02.146

Ultrastructural Study of Human Testicular Biopsies in Infertility

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100090762 ◽

1976 ◽

Vol 34 ◽

pp. 156-157

Author(s):

Shirley Siew ◽

Philip Troen ◽

Howard R. Nankin

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Basement Membrane ◽

Leydig Cells ◽

Clinical Evidence ◽

Young Male ◽

Germinal Epithelium ◽

Transmission Electron ◽

Age Range ◽

Male Subjects

Testicular biopsies were obtained from six young male subjects (age range 24-33) who complained of infertility and who had clinical evidence of oligospermia. This was confirmed on histological examination which showed a broad spectrum from profound hypospermatogenesis to relatively normal appearing germinal epithelium. Thickening of the tubular walls was noted in half of the cases and slight peritubular fibrosis in one. The Leydig cells were reported as normal or unremarkable.Transmission electron microscopy showed that the thickening of the supporting tissue of the germinal epithelium was caused more by an increase in the thickness of the layers of the lamina propria than of the tubular wall itself. The changes in the basement membrane of the tubular wall consisted mostly of a greater degree of infolding into the tubule and some reduplication which gave rise to a multilayered appearance.

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Remission of Recurrent Cochlear Hydrops Associated With Bromocriptine Treatment for Macroprolactinoma

American Journal of Audiology ◽

10.1044/2019_aja-18-0191 ◽

2019 ◽

Vol 28 (3) ◽

pp. 548-552

Author(s):

Andro Košec ◽

Ivan Kruljac ◽

Jakov Ajduk

Keyword(s):

Dopamine Receptors ◽

Male Patient ◽

Endolymphatic Hydrops ◽

Young Male ◽

Oral Steroid ◽

Case Description ◽

Diuretic Treatment ◽

Potential Therapeutic Role ◽

Transient Improvement ◽

Systemic Glucocorticoids

Objective Current recommendations for cochlear hydrops treatment include systemic glucocorticoids and diuretics. Cochlear cells express dopamine receptors, although their role is unknown in the pathophysiology of cochlear hydrops. Case Description We report the case of remission of recurrent right-sided cochlear hydrops in a young male patient treated with bromocriptine due to pituitary macroprolactinoma. Transient improvement was observed after oral steroid and diuretic treatment, but cochlear hydrops recurred until the dose of bromocriptine was increased to 10 mg daily. Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance.

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Abstract #1011: Galactorrhoea in a Young Male

Endocrine Practice ◽

10.1016/s1530-891x(20)44708-1 ◽

2016 ◽

Vol 22 ◽

pp. 233

Author(s):

Sachin Jain ◽

Mahender Rajput ◽

Anshuman Srivastava ◽

Ramesh Aggarwal ◽

Subodh Gururani ◽

...

Keyword(s):

Young Male

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Abstract #555 Parathyroid Crisis in a Young Male

Endocrine Practice ◽

10.1016/s1530-891x(20)47232-5 ◽

2018 ◽

Vol 24 ◽

pp. 137-138

Author(s):

Jahnavi Chakrala ◽

Syed-azhar Hassan ◽

Ayesha Siddiqui ◽

Ramachandra Rahul Chemitiganti ◽

James Burks

Keyword(s):

Young Male

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Young male drivers. Impulse expression, accidents, and violations

JAMA ◽

10.1001/jama.200.12.1026 ◽

1967 ◽

Vol 200 (12) ◽

pp. 1026-1030 ◽

Cited By ~ 8

Author(s):

S. H. Schuman

Keyword(s):

Young Male

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Effects of Antioxidant Supplementation and Exercise Training on Erythrocyte Antioxidant Enzymes

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.76.5.324 ◽

2006 ◽

Vol 76 (5) ◽

pp. 324-331 ◽

Cited By ~ 11

Author(s):

Marsh ◽

Laursen ◽

Coombes

Keyword(s):

Antioxidant Enzymes ◽

Exercise Training ◽

Endurance Training ◽

Young Male ◽

Antioxidant Defenses ◽

Antioxidant Enzyme Activities ◽

Antioxidant Supplementation ◽

Male Wistar Rats ◽

Exercise Induced ◽

Antioxidant Supplements

Erythrocytes transport oxygen to tissues and exercise-induced oxidative stress increases erythrocyte damage and turnover. Increased use of antioxidant supplements may alter protective erythrocyte antioxidant mechanisms during training. Aim of study: To examine the effects of antioxidant supplementation (α-lipoic acid and α-tocopherol) and/or endurance training on the antioxidant defenses of erythrocytes. Methods: Young male Wistar rats were assigned to (1) sedentary; (2) sedentary and antioxidant-supplemented; (3) endurance-trained; or (4) endurance-trained and antioxidant-supplemented groups for 14 weeks. Erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) activities, and plasma malondialdehyde (MDA) were then measured. Results: Antioxidant supplementation had no significant effect (p > 0.05) on activities of antioxidant enzymes in sedentary animals. Similarly, endurance training alone also had no effect (p > 0.05). GPX (125.9 ± 2.8 vs. 121.5 ± 3.0 U.gHb–1, p < 0.05) and CAT (6.1 ± 0.2 vs. 5.6 ± 0.2 U.mgHb–1, p < 0.05) activities were increased in supplemented trained animals compared to non-supplemented sedentary animals whereas SOD (61.8 ± 4.3 vs. 52.0 ± 5.2 U.mgHb–1, p < 0.05) activity was decreased. Plasma MDA was not different among groups (p > 0.05). Conclusions: In a rat model, the combination of exercise training and antioxidant supplementation increased antioxidant enzyme activities (GPX, CAT) compared with each individual intervention.

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Reaction Time and Brain Waves in Omitted Stimulus Tasks

Journal of Psychophysiology ◽

10.1027/0269-8803/a000001 ◽

2010 ◽

Vol 24 (1) ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Oscar H. Hernández ◽

Muriel Vogel-Sprott

Keyword(s):

Reaction Time ◽

Cognitive Processes ◽

Young Male ◽

Event Related Potential ◽

Auditory Stimuli ◽

Motor Action ◽

Cognitive Component ◽

Sensory Modalities ◽

Two Measures ◽

Somatosensory Stimuli

A missing stimulus task requires an immediate response to the omission of a regular recurrent stimulus. The task evokes a subclass of event-related potential known as omitted stimulus potential (OSP), which reflects some cognitive processes such as expectancy. The behavioral response to a missing stimulus is referred to as omitted stimulus reaction time (RT). This total RT measure is known to include cognitive and motor components. The cognitive component (premotor RT) is measured by the time from the missing stimulus until the onset of motor action. The motor RT component is measured by the time from the onset of muscle action until the completion of the response. Previous research showed that RT is faster to auditory than to visual stimuli, and that the premotor of RT to a missing auditory stimulus is correlated with the duration of an OSP. Although this observation suggests that similar cognitive processes might underlie these two measures, no research has tested this possibility. If similar cognitive processes are involved in the premotor RT and OSP duration, these two measures should be correlated in visual and somatosensory modalities, and the premotor RT to missing auditory stimuli should be fastest. This hypothesis was tested in 17 young male volunteers who performed a missing stimulus task, who were presented with trains of auditory, visual, and somatosensory stimuli and the OSP and RT measures were recorded. The results showed that premotor RT and OSP duration were consistently related, and that both measures were shorter with respect to auditory stimuli than to visual or somatosensory stimuli. This provides the first evidence that the premotor RT is related to an attribute of the OSP in all three sensory modalities.

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