Introduction: Clinical relevance of antimicrobial resistance☆

2001 ◽  
Vol 16 (3) ◽  
pp. 153-154 ◽  
Author(s):  
L MANDELL
Keyword(s):  
Antimicrobial Resistance ◽  
Clinical Relevance

scholarly journals The Intestinal Microbiome in Infectious Diseases: The Clinical Relevance of a Rapidly Emerging Field

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Vanessa C Harris ◽  
Bastiaan W Haak ◽  
Michaël Boele van Hensbroek ◽  
Willem J Wiersinga
Keyword(s):  
Infectious Disease ◽  
At Risk ◽  
Antimicrobial Resistance ◽  
Infectious Diseases ◽  
Paradigm Shift ◽  
Clinical Relevance ◽  
Intestinal Microbiome ◽  
Risk Patient ◽  
Immune Development ◽  
Enteric Infections

Abstract The field of infectious disease is undergoing a paradigm shift as the intestinal microbiome is becoming understood. The aim of this review is to inform infectious disease physicians of the potential relevance of the intestinal microbiome to their practice. We searched Medline using both index and text words relating to infectious diseases, microbiome, and probiotics. Relevant articles published up through 2017 were reviewed within Rayyan. The review illustrates pathophysiologic concepts linking the microbiome and infectious diseases; specifically, the intestinal microbiome’s relevance to early immune development, the microbiome and enteric infections, the microbiome’s relevance in compromised hosts, and antimicrobial resistance. Within each subject, there are specific examples of diseases and at-risk patient populations where a role for the microbiome has been strongly established. This provides an overview of the significance of the intestinal microbiome to microbiology, pediatric and adult infectious diseases with an underpinning of concepts useful for the practicing clinician.

scholarly journals The mcr-9 Gene of Salmonella and Escherichia coli Is Not Associated with Colistin Resistance in the United States

2020 ◽  
Vol 64 (8) ◽  
Author(s):  
Gregory H. Tyson ◽  
Cong Li ◽  
Chih-Hao Hsu ◽  
Sherry Ayers ◽  
Stacey Borenstein ◽  
...  
Keyword(s):  
United States ◽  
Escherichia Coli ◽  
Antimicrobial Resistance ◽  
Resistance Genes ◽  
Clinical Relevance ◽  
The United States ◽  
Colistin Resistance ◽  
Content Type ◽  
Long Read ◽  
Genetic Context

ABSTRACT Reports of transmissible colistin resistance show the importance of comprehensive colistin resistance surveillance. Recently, a new allele of the mobile colistin resistance (mcr) gene family designated mcr-9, which shows variation in genetic context and colistin susceptibility, was reported. We tested over 100 Salmonella enterica and Escherichia coli isolates with mcr-9 from the National Antimicrobial Resistance Monitoring System (NARMS) in the United States for their susceptibility to colistin and found that every isolate was susceptible, with an MIC of ≤1 μg/ml. Long-read sequencing of 12 isolates revealed mcr-9 on IncHI plasmids that were either independent or integrated into the chromosome. Overall, these results demonstrate that caution is necessary when determining the clinical relevance of new resistance genes.

scholarly journals The role of antimicrobials in management of periodontal diseases

Dental Update ◽  
2019 ◽  
Vol 46 (10) ◽  
pp. 952-958
Author(s):  
Bilawal Aziz Firdaus ◽  
Praveen Sharma ◽  
Michael Milward
Keyword(s):  
Antimicrobial Resistance ◽  
Treatment Response ◽  
Antimicrobial Therapy ◽  
Clinical Relevance ◽  
Periodontal Diseases ◽  
Appropriate Prescribing

With the looming threat posed by antimicrobial resistance, appropriate prescribing of antimicrobials, including antibiotics, is increasingly relevant. In this article, the reasons why antimicrobial therapy is not the mainstay of treatment for most patients with periodontitis will be explored. Some specific exceptions to this rule will also be investigated, including why such exceptions exist. In addition, the protocols for periodontal and antimicrobial therapy to maximize the treatment response when adjuvant antimicrobials are used will be presented. CPD/Clinical Relevance: This article highlights the need for appropriate prescribing within dentistry as a whole and specifically when it comes to the management of periodontal diseases, where antimicrobials do not form the mainstay of treatment, with some exceptions.

scholarly journals Identifying antimicrobial resistance genes of human clinical relevance within Salmonella isolated from food animals in Great Britain

2011 ◽  
Vol 66 (3) ◽  
pp. 550-559 ◽  
Author(s):  
Muna F. Anjum ◽  
Suman Choudhary ◽  
Victoria Morrison ◽  
Lucy C. Snow ◽  
Muriel Mafura ◽  
...  
Keyword(s):  
Great Britain ◽  
Antimicrobial Resistance ◽  
Resistance Genes ◽  
Clinical Relevance ◽  
Antimicrobial Resistance Genes ◽  
Food Animals

Selected Abstracts of Recent Research in Stuttering

1999 ◽  
Vol 9 (1) ◽  
pp. 5-6
Author(s):  
Carrie Bain ◽  
Nan Bernstein Ratner
Keyword(s):  
Large Volume ◽  
Clinical Relevance

Due to the large volume of fluency-related publications since the last column, we have chosen to highlight those articles of highest potential clinical relevance.

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