ABSTRACT Background:Metabolic changes seen after obstructive jaundice
increase the load of oxidative stress.The thiol-disulphide homeostasis
(TDB) has a vital importance as oxidatice stress biomarker. Aim: The aim
of present study is to investigate the dynamic thiol-disulphide
homeostasis in patients diagnosed with obstructive jaundice and to
compare the dynamic thiol-disulphide homeostasis with ischemia modified
albumin. Study design: A total of 146 participants who were admitted to
emergency department and who consisted of 69 patients and 77 healthy
volunteers, were included in the study. Detailed blood samples were
obtained from the patients at the time of admission. Methods: Thiol /
disulphide levels were examined using a novel method developed by Erel
and Neselioglu on the patients diagnosed with obstructive jaundice
during the admission. Data were evaluated in computer system. Results:
The levels of total thiol (p =0.025) and native thiol (p =0.023) were
statistically significantly lower in the patient with obstructive
jaundice than in the control group. It was observed that there was a
significant negative correlation between the native thiol levels and the
ALP (r =-0.262, p<0.01), urea (r =-0.313, p<0.01),
total bilirubin (r =-0.388, p<0.01), direct bilirubin (r
=-0.351, p<0.01) levels. At the same time, the level of
disulphide (p = 0.235) was lower in the patient group than in the
control group but not statistically significant. It was found that the
ischemia modified albumin (IMA) values were lower in the control group
than the obstructive jaundice group (p = 0.03). Conclusion: Total thiol,
native thiol and IMA levels decrease in obstructive jaundice
pathogenesis.
Effects of Phenytoin on Glutathione Status and Oxidative Stress Biomarker Gene mRNA Levels in Cultured Precision Human Liver Slices
