Surgical strategy for squamous cell carcinoma of the external auditory canal: management of locally advanced cases with skull base involvement

Objective Surgical indications for advanced-stage squamous cell carcinoma (SCC) of the external auditory canal (EAC) are highly dependent on the skull base surgery team. The aim of this study was to evaluate the surgical outcomes in patients with SCC of the EAC and to clarify the surgical indication of far advanced cases using the T4-subclassification. Methods Patients with SCC of the EAC who underwent curative treatment from 2002-2021 were retrospectively reviewed at our hospital. Clinical and surgical results, including operative data, overall survival (OS), and disease-specific survival (DSS) were analyzed. To clarify the surgical indication for advanced stage, we proposed the T4-subclassification. Results In 46 patients, the tumors were in T1 stage in 8 patients, T2 in 10, T3 in 5, and T4 in 23. The 5-year DSS with T1, T2, T3, and T4 tumors were 100%, 85.7%, 100%, and 61.7%, respectively. No prognostic impacts for margin status were found between the 5-year OS and DSS (p = 0.23 and p = 0.13). Patients with far advanced stage (T4b) tumors were significantly associated with shorter DSS than those with early stage (T1/T2) and advanced stage (T3/T4a) tumors (p = 0.007 and p = 0.03). Conclusion The present study focused on patients with SCC of the EAC at a University hospital over a period of 20-years, especially with skull base involvement, and a T4-subclassification was proposed. Complete tumor resection in an en bloc fashion could help to achieve a good survival rate even in patients with locally advanced tumors.

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Adenoid squamous cell carcinoma of right gingivobuccal sulcus – A rare case report

Asian Journal of Medical Sciences ◽

10.3126/ajms.v6i3.10793 ◽

2014 ◽

Vol 6 (3) ◽

pp. 94-96

Author(s):

Pankaj Pande ◽

Prakash Murigeppa Patil ◽

Mihir J. Bhalodia ◽

Jyotirling Savle ◽

Himanshu Mulay

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Rare Case ◽

Locally Advanced ◽

Advanced Stage ◽

Medical Sciences ◽

The World ◽

Rare Case Report ◽

Common Malignancy

Oral cancer is the sixth most common malignancy in the world and third most common in southeast Asia. When it does occur, it is most commonly seen on the tongue or lip. Cancers of the gingivobuccal sulcus are uncommon and reported infrequently. Here we report a case of 35 years female diagnosed with adenoid squamous cell carcinoma of right gingivobuccal sulcus. Most of these cancers are locally advanced stage due to delay in presentation and ignorance of population. DOI: http://dx.doi.org/10.3126/ajms.v6i3.10793Asian Journal of Medical Sciences Vol.6(3) 2015 94-96

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Significance of mammalian target of rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Head & Neck ◽

10.1002/hed.24111 ◽

2015 ◽

Vol 38 (S1) ◽

pp. E844-E852 ◽

Cited By ~ 12

Author(s):

Shau-Hsuan Li ◽

Wei-Che Lin ◽

Tai-Lin Huang ◽

Chang-Han Chen ◽

Tai-Jan Chiu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Induction Chemotherapy ◽

Squamous Cell ◽

Locally Advanced ◽

Mammalian Target Of Rapamycin ◽

Stage Iv ◽

Neck Squamous Cell Carcinoma ◽

Advanced Stage

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A Prospective Observational Study on Treatment Evaluation in Patients Newly Diagnosed with Squamous Cell Carcinoma of Head and Neck in Bangladesh

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v10i1.43654 ◽

2019 ◽

Vol 10 (1) ◽

pp. 17-22

Author(s):

MA Hai ◽

Ehteshamul Haque ◽

Salim Reza ◽

Mokhles Uddin ◽

Kumkum Pervin

Keyword(s):

Risk Factors ◽

Squamous Cell Carcinoma ◽

Clinical Practice ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Locally Advanced ◽

Routine Clinical Practice ◽

Advanced Stage ◽

Newly Diagnosed

Background: Most head and neck cancers are squamous cell carcinomas (SCCHN) that contribute to substantial morbidity and mortality worldwide. The disease is mostly diagnosed at locally advanced stage. Because treatment of head and neck cancers is complex and involves multiple modalities of surgery, radiotherapy and systemic therapy including chemotherapy and molecularly targeted agents; a multidisciplinary approach is needed. The study evaluated the current treatment approaches for patients newly diagnosed with SCCHN in Bangladesh. Methods: This prospective, observational and non-comparative, study enrolled eligible males and females of 18 years newly diagnosed with SCCHN at any stage of disease. No therapeutic intervention was implied rather selection of treatment strategy and dosage of therapy was on discretion of individual oncologist as per routine clinical practice. Results: A total of 64 patients with median age of 55 years were enrolled between August 2008 and July 2011. The majority of patients (42, 65.6%) were males. The major risk factors were betel leaf chewing along with jorda (smokeless tobacco) (62.5%) and cigarette smoking (32.8%), though most of the patients had multiple risk factors. No patient was diagnosed at early stage; all were in locally advanced disease at stage III (52, 81.3%) and IV (12, 18.8%). The oncologists prescribed neoadjuvant chemotherapy in half (32) of the patients, 19 (29.7%) patients received adjuvant chemotherapy and 13 (20.3%) received palliative chemotherapy. Only 3 (4.6%) of the patients received radiotherapy. Chemotherapy combination regimen included docetaxel, cisplatin and 5-fluorouracil (5-FU) and leucovorin was added to 2 patients. The dosage of chemotherapeutic agents was as per routine clinical practice of the oncologists. Neutropenia was the common hematological abnormality reported spontaneously in 16 (25%) patients. No serious adverse event was reported leading the patients to withdraw from therapy. During continuation of therapy 1 patient died due to sudden cardiac arrest who had medical history of previous myocardial infarction. Conclusion: This registry revealed that squamous cell carcinoma of head and neck region are mostly presented in advanced stage in Bangladesh and the majority of the patients are treated with combination chemotherapeutic regimens. Anwer Khan Modern Medical College Journal Vol. 10, No. 1: Jan 2019, P 17-22

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Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

World Journal of Surgical Oncology ◽

10.1186/s12957-016-0844-2 ◽

2016 ◽

Vol 14 (1) ◽

Cited By ~ 2

Author(s):

Yan-Ye Su ◽

Chih-Yen Chien ◽

Sheng-Dean Luo ◽

Tai-Lin Huang ◽

Wei-Che Lin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Induction Chemotherapy ◽

Squamous Cell ◽

Locally Advanced ◽

Stage Iv ◽

Advanced Stage ◽

Betel Nut ◽

Betel Nut Chewing

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Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-021-06974-4 ◽

2021 ◽

Author(s):

Hirotaka Shinomiya ◽

Natsumi Uehara ◽

Takeshi Fujita ◽

Daisuke Miyawaki ◽

Yoshinori Imamura ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Phase I ◽

Cell Carcinoma ◽

Squamous Cell ◽

External Auditory Canal ◽

Phase I Trial ◽

Concurrent Chemoradiotherapy ◽

Locally Advanced ◽

Advanced Squamous Cell Carcinoma

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Osteopontin Involves Cisplatin Resistance and Poor Prognosis in Oral Squamous Cell Carcinoma

BioMed Research International ◽

10.1155/2015/508587 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 6

Author(s):

Sheng-Dean Luo ◽

Yi-Ju Chen ◽

Chien-Ting Liu ◽

Kun-Ming Rau ◽

Yi-Ching Chen ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cancer ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Locally Advanced ◽

Cancer Cell Line ◽

Poor Response ◽

Advanced Stage ◽

Cancer Line

Background.Osteopontin (OPN) is a multifunctional cytokine involved in cell survival, migration, and adhesion. However, its role in chemosensitivity in locally advanced oral squamous cell carcinoma (OSCC) in humans has not yet been investigated.Methods.We enrolled 121 patients with locally advanced stage IVA/B OSCC receiving cisplatin-based IC followed by CCRT from January 1, 2006, through January 1, 2012. Immunohistochemistry was used to assess OPN expression in OSCC patients’ biopsy specimens from paraffin blocks before treatment. In addition, MTT/colony formation assay was used to estimate the influence of OPN in an oral cancer cell line treated with cisplatin.Results.Of the 121 patients, 94 had positive OPN findings and 52 responded to IC followed by CCRT. Positive osteopontin immunostaining also correlated significantly with positive N status/TNM stage/male gender and smoking. Univariate analyses showed that patients whose tumors had a low expression of OPN were more likely to respond to chemotherapy and have a significantly better OS than those whose tumors had a high expression of OPN. Multivariate analysis revealed that prolonged survival was independently predicted for patients with stage IVA disease, negative lymph nodes, and negative expressions of OPN and for those who received chemotherapy with Docetaxel/cisplatin/fluorouracil (TPF). An oral cancer line stimulated with OPN exhibited a dose-dependent resistance to cisplatin treatment. Conversely, endogenous OPN depletion by OPN-mediated shRNA increased sensitivity to cisplatin.Conclusions.A positive expression of OPN predicts a poor response and survival in patients with locally advanced stage IVA/B OSCC treated with cisplatin-based IC followed by CCRT.

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