Antimycobacterial activity of medicinal plants from Mozambique

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
G Da Silva ◽  
A Macedo ◽  
I Famba ◽  
M Taniça ◽  
R Serrano ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity

In vitro evaluation of the anti-mycobacterial properties of the extracts of Momordica Charantia

2021 ◽  
Vol 16 (7) ◽  
pp. 15-22
Author(s):  
Paul Giftson ◽  
Jerrine Joseph ◽  
Revathy Kalyanasundaram ◽  
V. Ramesh Kumar ◽  
Wilson Aruni
Keyword(s):  
Medicinal Plants ◽  
Fungal Pathogens ◽  
Communicable Disease ◽  
Antimycobacterial Activity ◽  
Bitter Gourd ◽  
World Population ◽  
Methanol Extracts ◽  
Crude Extracts ◽  
The World

Tuberculosis (TB) is a communicable disease and remains one of the top 10 causes of death worldwide. One fourth of the world population is infected with TB at a risk of developing disease. The increase in the incidence of drug resistant TB around the world urges the need to develop a new candidate to fight against the disease. Plants were considered as the rich source of bioactive components to be used as potential drugs. Medicinal plants are used in pure as well as crude materials for their medicinal properties. Our research aims in identifying the phyto-molecules which have anti- tuberculosis property. Four medicinal plants namely, Acalyphaciliata (Kuppaimeni), Solanumtrilobatum (Thuthuvalai), Momordicacharantia (Bitter Gourd) and Sennaauriculata (Avaram) were chosen to evaluate their antimicrobial activity focusing on anti-tubercular activity. The methanol extracts of the medicinal plants showed significant inhibitory activity against bacterial and fungal pathogens. Sennaauriculata methanol extracts showed activity against S. aureus, E. coli, P. aeruginosa and C. albicans. In the screening of antimycobacterial activity done by LRP assay, among the plant extracts tested, the hexane crude extracts of Momordicacharantia (Bitter Gourd) showed 82.2% and 81.03% of inhibition against M. tuberculosis H37Rv at 500µg/ml and 250µg/ml concentration respectively. Similarly, the methanol crude extracts of Momordicacharantia showed 87.14% and 63.55% of inhibition at 500µg/ml and 250µg/ml concentration respectively.

Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay

2010 ◽  
Vol 56 (6) ◽  
pp. 487-494 ◽  
Author(s):  
Duncan Webster ◽  
Timothy D.G. Lee ◽  
Jill Moore ◽  
Tracy Manning ◽  
Dennis Kunimoto ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
First Nations ◽  
Antimycobacterial Activity ◽  
Multidrug Resistant ◽  
Positive Control ◽  
Health Concern ◽  
Acorus Calamus ◽  
Aqueous Extracts ◽  
Resazurin Assay

Multidrug-resistant Mycobacterium tuberculosis strains have rapidly become a global health concern. North American First Nations communities have used traditional medicines for generations to treat many pulmonary infections. In this study, we evaluated the antimycobacterial activity of 5 medicinal plants traditionally used as general therapeutics for pulmonary illnesses and specifically as treatments for tuberculosis. Aqueous extracts of Aralia nudicaulis , Symplocarpus foetidus , Heracleum maximum , Juniperus communis, and Acorus calamus were screened for antimycobacterial activity against Bacillus Calmette–Guérin, Mycobacterium avium, and M. tuberculosis H37Ra using the colorimetric microplate resazurin assay. Extracts of Acorus calamus and H. maximum root demonstrated significant antimycobacterial activity comparable to that of the rifampin control (2 µg/mL). Evaluation of the cytotoxicity of these 2 extracts using the MTT assay also showed that the extracts were less toxic to 3 human cell lines than was the DMSO positive control. This study demonstrates that aqueous extracts of the roots of H. maximum and Acorus calamus possess strong in vitro antimycobacterial activity, validates traditional knowledge, and provides potential for the development of urgently needed novel antituberculous therapeutics.

scholarly journals AntiMycobacterial activity of endophytic actinobacteria from selected medicinal plants

2020 ◽  
Vol 4 (3) ◽  
pp. 193
Author(s):  
Radhakrishnan Manikkam ◽  
Alka Ashok ◽  
Usha Nandhini ◽  
Ayswarya Sreenivasan ◽  
Manigundan Kaari ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity ◽  
Endophytic Actinobacteria

Antimycobacterial activity of traditional medicinal plants used in Mozambique

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
X Luo ◽  
D Pires ◽  
J Ainsa ◽  
B Gracia ◽  
S Mulhovo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity ◽  
Traditional Medicinal Plants

scholarly journals In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and nonpathogenic mycobacterial strains

2016 ◽  
Vol 5 ◽  
pp. S106-S107
Author(s):  
Joseph M. Nguta ◽  
Regina Appiah-Opong ◽  
Alexander K. Nyarko ◽  
Dorothy Yeboah-Manu ◽  
Phyllis G.A. Addo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity

scholarly journals Hyptis brevipes AND Paullinia pinnata EXTRACTS AND THEIR FRACTIONS PRESENTING ACTIVITY AGAINST Mycobacterium abscessus subsp. massiliense

2019 ◽  
Vol 48 (3) ◽  
pp. 148-160
Author(s):  
Rogério Coutinho Das Neves ◽  
Rayanny Gomes Andrade ◽  
Carlos Alexandre Carollo ◽  
Amanda Galdi Boaretto ◽  
Andre Kipnis ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity ◽  
Ethyl Acetate Fraction ◽  
Mycobacterium Abscessus ◽  
Minimal Bactericidal Concentration ◽  
Emerging Pathogen ◽  
Underdeveloped Countries ◽  
Medicinal Plant Extracts ◽  
Bactericidal Function ◽  
Brazilian Medicinal Plants

Medicinal plants are of great interest for the discovery of new biomolecules with diversified effects. Over the last decade different outbreaks caused by Mycobacterium abscessus subsp. massiliense have been reported, evidencing it as an important emerging pathogen in underdeveloped countries. This study investigated the antimycobacterial activity of six Brazilian medicinal plant extracts and their fractions. Hyptis brevipes, Tocoyena formosa, Randia armata, Paullinia pinnata, Lafoensia pacari and Anadenanthera colubrina were evaluated against M. a. massiliense. Total extracts from the medicinal plants H. brevipes, T. formosa, P. pinnata and L. pacari presented a minimal bactericidal concentration of 1 mg/mL. After fractioning, the ethanolic fractions from H. brevipes and P. pinnata presented bactericidal activity, and the ethyl acetate fraction from H. brevipes and T. formosa presented antimycobacterial action. The best bactericidal function of all plant fractions was the ethanolic, which contained rutin and rosmarinic acid that were shown to have microbicidal activity. KEY WORDS: Mycobacterium abscessus; medicinal plants; Brazilian medicinal plants; HPLCand biodiversity.

scholarly journals Antimycobacterial activity of selected medicinal plants extracts from Cameroon

2014 ◽  
Vol 8 (1) ◽  
pp. 273 ◽  
Author(s):  
VF Donkeng Donfack ◽  
S Roque ◽  
G Trigo ◽  
PV Tsouh Fokou ◽  
LR Yamthe Tchokouaha ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity

Screening of some New Caledonian and Vanuatu medicinal plants for antimycobacterial activity

2005 ◽  
Vol 96 (1-2) ◽  
pp. 195-200 ◽  
Author(s):  
M. Billo ◽  
P. Cabalion ◽  
J. Waikedre ◽  
C. Fourneau ◽  
S. Bouttier ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity
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