scholarly journals In vitro antimycobacterial activity and toxicity of eight medicinal plants against pathogenic and nonpathogenic mycobacterial strains

2016 ◽  
Vol 5 ◽  
pp. S106-S107
Author(s):  
Joseph M. Nguta ◽  
Regina Appiah-Opong ◽  
Alexander K. Nyarko ◽  
Dorothy Yeboah-Manu ◽  
Phyllis G.A. Addo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity

In vitro evaluation of the anti-mycobacterial properties of the extracts of Momordica Charantia

2021 ◽  
Vol 16 (7) ◽  
pp. 15-22
Author(s):  
Paul Giftson ◽  
Jerrine Joseph ◽  
Revathy Kalyanasundaram ◽  
V. Ramesh Kumar ◽  
Wilson Aruni
Keyword(s):  
Medicinal Plants ◽  
Fungal Pathogens ◽  
Communicable Disease ◽  
Antimycobacterial Activity ◽  
Bitter Gourd ◽  
World Population ◽  
Methanol Extracts ◽  
Crude Extracts ◽  
The World

Tuberculosis (TB) is a communicable disease and remains one of the top 10 causes of death worldwide. One fourth of the world population is infected with TB at a risk of developing disease. The increase in the incidence of drug resistant TB around the world urges the need to develop a new candidate to fight against the disease. Plants were considered as the rich source of bioactive components to be used as potential drugs. Medicinal plants are used in pure as well as crude materials for their medicinal properties. Our research aims in identifying the phyto-molecules which have anti- tuberculosis property. Four medicinal plants namely, Acalyphaciliata (Kuppaimeni), Solanumtrilobatum (Thuthuvalai), Momordicacharantia (Bitter Gourd) and Sennaauriculata (Avaram) were chosen to evaluate their antimicrobial activity focusing on anti-tubercular activity. The methanol extracts of the medicinal plants showed significant inhibitory activity against bacterial and fungal pathogens. Sennaauriculata methanol extracts showed activity against S. aureus, E. coli, P. aeruginosa and C. albicans. In the screening of antimycobacterial activity done by LRP assay, among the plant extracts tested, the hexane crude extracts of Momordicacharantia (Bitter Gourd) showed 82.2% and 81.03% of inhibition against M. tuberculosis H37Rv at 500µg/ml and 250µg/ml concentration respectively. Similarly, the methanol crude extracts of Momordicacharantia showed 87.14% and 63.55% of inhibition at 500µg/ml and 250µg/ml concentration respectively.

Antimycobacterial screening of traditional medicinal plants using the microplate resazurin assay

2010 ◽  
Vol 56 (6) ◽  
pp. 487-494 ◽  
Author(s):  
Duncan Webster ◽  
Timothy D.G. Lee ◽  
Jill Moore ◽  
Tracy Manning ◽  
Dennis Kunimoto ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
First Nations ◽  
Antimycobacterial Activity ◽  
Multidrug Resistant ◽  
Positive Control ◽  
Health Concern ◽  
Acorus Calamus ◽  
Aqueous Extracts ◽  
Resazurin Assay

Multidrug-resistant Mycobacterium tuberculosis strains have rapidly become a global health concern. North American First Nations communities have used traditional medicines for generations to treat many pulmonary infections. In this study, we evaluated the antimycobacterial activity of 5 medicinal plants traditionally used as general therapeutics for pulmonary illnesses and specifically as treatments for tuberculosis. Aqueous extracts of Aralia nudicaulis , Symplocarpus foetidus , Heracleum maximum , Juniperus communis, and Acorus calamus were screened for antimycobacterial activity against Bacillus Calmette–Guérin, Mycobacterium avium, and M. tuberculosis H37Ra using the colorimetric microplate resazurin assay. Extracts of Acorus calamus and H. maximum root demonstrated significant antimycobacterial activity comparable to that of the rifampin control (2 µg/mL). Evaluation of the cytotoxicity of these 2 extracts using the MTT assay also showed that the extracts were less toxic to 3 human cell lines than was the DMSO positive control. This study demonstrates that aqueous extracts of the roots of H. maximum and Acorus calamus possess strong in vitro antimycobacterial activity, validates traditional knowledge, and provides potential for the development of urgently needed novel antituberculous therapeutics.

scholarly journals In vitro Antimycobacterial Activity of Selected Medicinal Plants against Mycobacterium tuberculosis

2021 ◽  
Vol 10 (2) ◽  
pp. 3201-3208
Author(s):  
Kpatcha E. Poro Yao Hoekou ◽  
Passimna Pissang Iwaba Kpabi ◽  
Kosi M. Novidzro Anoumou Y. Dagnra ◽  
Tchadjobo Tchacondo Komlan Batawila
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Antimycobacterial Activity

scholarly journals In vitro antimycobacterial activity of six Cameroonian medicinal plants using microplate alamarBlue assay

2015 ◽  
Vol 4 (4) ◽  
pp. 306-311 ◽  
Author(s):  
Céline Nguefeu Nkenfou ◽  
Isabelle Kamga Mawabo ◽  
Augustin Notedji ◽  
Jean Nkenfou ◽  
Patrick Valere Tsouh Fokou ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity ◽  
Alamarblue Assay

Antimycobacterial activity of medicinal plants from Mozambique

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
G Da Silva ◽  
A Macedo ◽  
I Famba ◽  
M Taniça ◽  
R Serrano ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimycobacterial Activity

In Vitro Anti-Infective Screening Of Selected West African Medicinal Plants

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
VO Imieje ◽  
PS Fasinu ◽  
KO Ogbeide ◽  
NO Egiebor ◽  
A Falodun
Keyword(s):  
Medicinal Plants ◽  
West African

Natural products from the traditional Moroccan pharmacopoeia: A potential lead for the prevention and treatment of COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Treatment Protocol ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Promising Source

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.

Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

2020 ◽  
Vol 26 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Bhasha Shanmugam ◽  
Gangigunta Venkatasubbaiah ◽  
Sahukari Ravi ◽  
Kesireddy Sathyavelu Reddy
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Diabetes Management ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
In Vivo Studies ◽  
Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

Sign in / Sign up

Export Citation Format

Share Document