Die Induktion der gastralen Progranulin-Expression durch H. pylori ist unabhängig von der mukosalen Konzentration des „Secretory Leukocyte Protease Inhibitor„ (SLPI)

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
T Wex ◽  
D Kuester ◽  
C Schönberg ◽  
D Schindele ◽  
G Treiber ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
H Pylori

scholarly journals Mucosal Progranulin expression is induced by H. pylori, but independent of Secretory Leukocyte Protease Inhibitor (SLPI) expression

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Thomas Wex ◽  
Doerthe Kuester ◽  
Cornelius Schönberg ◽  
Daniel Schindele ◽  
Gerhard Treiber ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
H Pylori

scholarly journals Helicobacter pylori-Mediated Gastritis Induces Local Downregulation of Secretory Leukocyte Protease Inhibitor in the Antrum

2004 ◽  
Vol 72 (4) ◽  
pp. 2383-2385 ◽  
Author(s):  
Thomas Wex ◽  
Gerhard Treiber ◽  
Manfred Nilius ◽  
Michael Vieth ◽  
Albert Roessner ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
H Pylori

ABSTRACT Helicobacter pylori-infected subjects exhibited a strong decline in antral secretory leukocyte protease inhibitor (SLPI) levels compared to H. pylori-negative subjects and subjects from whom H. pylori had been eradicated (P = 0.002). This reduction was specific for the antrum, whereas SLPI expression in corpus and duodenum was not affected. Antral SLPI levels were inversely correlated with inflammatory scores of antrum-predominant gastritis.

scholarly journals SLPI is a critical mediator that controls PTH-induced bone formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Akito Morimoto ◽  
Junichi Kikuta ◽  
Keizo Nishikawa ◽  
Takao Sudo ◽  
Maki Uenaka ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Formation ◽  
Protease Inhibitor ◽  
Bone Metabolism ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Bone Imaging ◽  
Genetic Ablation

AbstractOsteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although it is unclear how these cells are coordinately regulated by PTH. Here, we identify a serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI), as a critical mediator that is involved in the PTH-mediated shift to the osteoblastic phase. Slpi is highly upregulated in osteoblasts by PTH, while genetic ablation of Slpi severely impairs PTH-induced bone formation. Slpi induction in osteoblasts enhances its differentiation, and increases osteoblast–osteoclast contact, thereby suppressing osteoclastic function. Intravital bone imaging reveals that the PTH-mediated association between osteoblasts and osteoclasts is disrupted in the absence of SLPI. Collectively, these results demonstrate that SLPI regulates the communication between osteoblasts and osteoclasts to promote PTH-induced bone anabolism.

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