Chemical investigation and evaluation of analgesic and anti-inflammatory activies of Copaifera langsdorffii leaf extract

Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-α) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-κB) and inhibitor of Kappa Bα (IκBα), and blunted LPS-triggered enhanced nuclear translocation of NF-κB p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-κB and p38/JNK signaling pathways.

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Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

Neuroscience &amp Medicine ◽

10.4236/nm.2019.103020 ◽

2019 ◽

Vol 10 (03) ◽

pp. 259-271

Author(s):

Loyce Nakalembe ◽

Josephine N. Kasolo ◽

Edward Nyatia ◽

Aloysius Lubega ◽

Godfrey S. Bbosa

Keyword(s):

Leaf Extract ◽

Inflammatory Activity ◽

Albino Rats ◽

Phytolacca Dodecandra ◽

Crude Leaf Extract ◽

Anti Inflammatory ◽

Wistar Albino Rats

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Green synthesis of silver nanoparticles from Lonicera japonica leaf extract and their anti‐inflammatory and antibacterial effects

Micro & Nano Letters ◽

10.1049/mnl.2019.0343 ◽

2020 ◽

Vol 15 (2) ◽

pp. 90-95

Author(s):

Luyun Yan ◽

Beibei Qiu ◽

Tongtong Li ◽

Dandan Wu ◽

Jinhua Zhu ◽

...

Keyword(s):

Silver Nanoparticles ◽

Green Synthesis ◽

Leaf Extract ◽

Lonicera Japonica ◽

Antibacterial Effects ◽

Anti Inflammatory

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Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents

Herba Polonica ◽

10.2478/hepo-2019-0015 ◽

2019 ◽

Vol 65 (3) ◽

pp. 22-31

Author(s):

Ighodaro Igbe ◽

Osaze Edosuyi ◽

Agbonlahor Okhuarobo ◽

Adarki Pongri ◽

Nkechi Maduako ◽

...

Keyword(s):

Acetic Acid ◽

Analgesic Effect ◽

Leaf Extract ◽

Methanol Extract ◽

Tail Flick ◽

Hot Plate ◽

Analgesic Effects ◽

Paw Oedema ◽

Anti Inflammatory ◽

Ear Oedema

Summary Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for anti-inflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalin-induced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.

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Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20204084 ◽

2020 ◽

Vol 9 (10) ◽

pp. 1477

Author(s):

Anthony U. Megwas ◽

Godwin C. Akuodor ◽

Leo C. Chukwu ◽

Daniel O. Aja ◽

Edmund M. Okorie ◽

...

Keyword(s):

Animal Models ◽

Leaf Extract ◽

Therapeutic Potential ◽

Ethanol Extract ◽

Tail Flick ◽

Experimental Animal Models ◽

Antipyretic Activity ◽

Egg Albumen ◽

Anti Inflammatory ◽

Abdominal Constriction

Background: This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals.Methods: The analgesic activity was measured using the abdominal constriction and tail flick tests. The anti-inflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively.Results: The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities.Conclusions: Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.

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