scholarly journals Syzygium aqueum: A Polyphenol- Rich Leaf Extract Exhibits Antioxidant, Hepatoprotective, Pain-Killing and Anti-inflammatory Activities in Animal Models

2018 ◽  
Vol 9 ◽  
Author(s):  
Mansour Sobeh ◽  
Mona F. Mahmoud ◽  
Ganna Petruk ◽  
Samar Rezq ◽  
Mohamed L. Ashour ◽  
...  
Keyword(s):  
Animal Models ◽  
Leaf Extract ◽  
Anti Inflammatory

scholarly journals Analgesic, anti-inflammatory and antipyretic activities of ethanol extract of Annona senegalensis leaves in experimental animal models

2020 ◽  
Vol 9 (10) ◽  
pp. 1477
Author(s):  
Anthony U. Megwas ◽  
Godwin C. Akuodor ◽  
Leo C. Chukwu ◽  
Daniel O. Aja ◽  
Edmund M. Okorie ◽  
...  
Keyword(s):  
Animal Models ◽  
Leaf Extract ◽  
Therapeutic Potential ◽  
Ethanol Extract ◽  
Tail Flick ◽  
Experimental Animal Models ◽  
Antipyretic Activity ◽  
Egg Albumen ◽  
Anti Inflammatory ◽  
Abdominal Constriction

Background: This study was carried out to establish the analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Anonna senegalensis leaves in experimental animals.Methods: The analgesic activity was measured using the abdominal constriction and tail flick tests. The anti-inflammatory activity was performed using xylene and egg-albumen paw induced tests, while the antipyretic activity was measured using brewer’s yeast and 2, 4 dinitrophenol induced pyrexia tests, respectively.Results: The leaf extract at all doses used exhibited significant (p<0.05) analgesic, anti-inflammatory and antipyretic activities.Conclusions: Results show that ethanol leaf extract of Anonna senegalensis possess therapeutic potential against pains and feverish conditions, supporting the claims of its this plant as remedy for similar ailments.

scholarly journals An evaluation of the anti-inflammatory, antipyretic and analgesic effects of hydroethanol leaf extract of Albizia zygia in animal models

2016 ◽  
Vol 55 (1) ◽  
pp. 338-348 ◽  
Author(s):  
Wonder Kofi Mensah Abotsi ◽  
Stanley Benjamin Lamptey ◽  
Stephen Afrane ◽  
Eric Boakye-Gyasi ◽  
Ruth Uwa Umoh ◽  
...  
Keyword(s):  
Animal Models ◽  
Leaf Extract ◽  
Analgesic Effects ◽  
Anti Inflammatory

scholarly journals Musanga cecropioides leaf extract exhibits anti-inflammatory and anti-nociceptive activities in animal models

2015 ◽  
Vol 25 (5) ◽  
pp. 506-512 ◽  
Author(s):  
Abimbola Sowemimo ◽  
Eboji Okwuchuku ◽  
Fageyinbo Muyiwa Samuel ◽  
Olowokudejo Ayoola ◽  
Ibrahim Mutiat
Keyword(s):  
Animal Models ◽  
Leaf Extract ◽  
Anti Inflammatory

scholarly journals Phytochemical Screening and Anti-Inflammatory Activities of Methanolic Leaf Extract of Bauhinia monandra in Animal Models

2018 ◽  
Vol 11 ◽  
pp. 7-16
Author(s):  
Augustine Nkemakolam Okorie ◽  
Kelechi Martins Nworie
Keyword(s):  
Animal Models ◽  
Topical Application ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Therapeutic Potential ◽  
Phytochemical Screening ◽  
Paw Edema ◽  
Egg Albumin ◽  
Ear Edema ◽  
Anti Inflammatory

The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration (200 and 400 mg/kg) led to significant (p<0,05) reduction (31.0% and 28.0% respectively) of the egg albumin-induced paw edema. Topical application of mice ear with MEBmL (50, 100 mg/kg) also significantly (p<0.05) reduced (39.50% and 41.87% respectively) xylene-induced ear edema. Based on the findings of the study, B. monandra has a promising therapeutic potential with its anti-inflammatory activities as associated with folkloric use of the plant.

Consideration of a Pharmacological Combinatorial Approach to Inhibit Chronic Inflammation in Alzheimer’s Disease

2019 ◽  
Vol 16 (11) ◽  
pp. 1007-1017 ◽  
Author(s):  
James G. McLarnon
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Chronic Inflammation ◽  
Preventive Strategy ◽  
Subsequent Work ◽  
Activated Microglia ◽  
Starting Point ◽  
Anti Inflammatory ◽  
Cocktail Approach

A combinatorial cocktail approach is suggested as a rationale intervention to attenuate chronic inflammation and confer neuroprotection in Alzheimer’s disease (AD). The requirement for an assemblage of pharmacological compounds follows from the host of pro-inflammatory pathways and mechanisms present in activated microglia in the disease process. This article suggests a starting point using four compounds which present some differential in anti-inflammatory targets and actions but a commonality in showing a finite permeability through Blood-brain Barrier (BBB). A basis for firstchoice compounds demonstrated neuroprotection in animal models (thalidomide and minocycline), clinical trial data showing some slowing in the progression of pathology in AD brain (ibuprofen) and indirect evidence for putative efficacy in blocking oxidative damage and chemotactic response mediated by activated microglia (dapsone). It is emphasized that a number of candidate compounds, other than ones suggested here, could be considered as components of the cocktail approach and would be expected to be examined in subsequent work. In this case, systematic testing in AD animal models is required to rigorously examine the efficacy of first-choice compounds and replace ones showing weaker effects. This protocol represents a practical approach to optimize the reduction of microglial-mediated chronic inflammation in AD pathology. Subsequent work would incorporate the anti-inflammatory cocktail delivery as an adjunctive treatment with ones independent of inflammation as an overall preventive strategy to slow the progression of AD.

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

2013 ◽  
Vol 16 (8) ◽  
pp. 740-748 ◽  
Author(s):  
Neelakandan Yuvaraj ◽  
Paulraj Kanmani ◽  
Ramraj Satishkumar ◽  
Alagesan Paari ◽  
Vellaiyan Pattukumar ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Sulfated Polysaccharides ◽  
Experimental Animal Models ◽  
Sargassum Wightii ◽  
Halophila Ovalis ◽  
Anti Inflammatory
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