Oleacein from olive oil inhibits myeloperoxidase and metalloproteinase-9 production by atherosclerotic plaque

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
ME Czerwińska ◽  
A Filipek ◽  
AK Kiss ◽  
JA Polański ◽  
RM Proczka ◽  
...  
Keyword(s):  
Olive Oil ◽  
Atherosclerotic Plaque ◽  
Metalloproteinase 9

scholarly journals Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 mRNAs in Patients with Primary Hypertension or Hypertension-Induced Atherosclerosis

2012 ◽  
Vol 40 (3) ◽  
pp. 986-994 ◽  
Author(s):  
W Su ◽  
F Gao ◽  
J Lu ◽  
W Wu ◽  
G Zhou ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Matrix Metalloproteinase 9 ◽  
Primary Hypertension ◽  
Mrna Levels ◽  
Tissue Inhibitor ◽  
Hypertensive Patients ◽  
Matrix Metalloproteinase 1 ◽  
Normotensive Subjects ◽  
Metalloproteinase 9

OBJECTIVE: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) affect degradation of vascular elastin, collagen remodelling and formation of atherosclerotic plaque. This cross-sectional study investigated the levels of MMP-9 and TIMP-1 mRNAs in the blood of patients with primary hypertension with and without hypertension-induced carotid atherosclerosis. METHODS: Hypertensive patients with and without atherosclerosis and age- and gender-matched normotensive subjects were enrolled. MMP-9 and TIMP-1 mRNA were quantified using real-time reverse transcription—polymerase chain reaction. RESULTS: Hypertensive patients ( n = 86) had significantly lower levels of TIMP-1 mRNA than normotensive subjects ( n = 43). Hypertensive patients with atherosclerosis ( n = 42) showed significantly elevated levels of MMP-9 mRNA compared with both normotensive subjects and hypertensive patients without atherosclerosis ( n = 44). CONCLUSIONS: Primary hypertension resulted in decreased TIMP-1 mRNA levels, suggesting a potential mechanism contributing to the degradation of elastin. Hypertension-induced atherosclerosis was associated with significantly increased levels of MMP-9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation.

scholarly journals The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Tiewei Li ◽  
Xiaojuan Li ◽  
Yichuan Feng ◽  
Geng Dong ◽  
Yuewu Wang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Predictive Biomarker ◽  
Matrix Metalloproteinase 9 ◽  
Atherosclerotic Plaques ◽  
Plaque Instability ◽  
Cerebrovascular Events ◽  
Plaque Inflammation ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability. Studies have demonstrated that MMP-9 levels are higher in vulnerable plaques than in stable plaques. Additionally, several human studies have demonstrated that MMP-9 may be a predictor of atherosclerotic plaque instability and a risk factor for future adverse cardiovascular and cerebrovascular events. MMP-9 deficiency or blocking MMP-9 expression can inhibit plaque inflammation and prevent atherosclerotic plaque instability. All of these results suggest that MMP-9 may be a useful predictive biomarker for vulnerable atherosclerotic plaques, as well as a therapeutic target for preventing atherosclerotic plaque instability. In this review, we describe the structure, function, and regulation of MMP-9. We also discuss the role of MMP-9 in predicting and preventing atherosclerotic plaque instability.

We-P14:422 Olive oil phenols modulate TNF-alpha-induced matrix metalloproteinase-9 in THP-1 cells

2006 ◽  
Vol 7 (3) ◽  
pp. 439-440
Author(s):  
R. Fagnani ◽  
M. Dell'Agli ◽  
S. Bellosta ◽  
G.V. Galli ◽  
R. Parente ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Olive Oil ◽  
Matrix Metalloproteinase 9 ◽  
Tnf Alpha ◽  
Metalloproteinase 9

Abstract: P1416 OLIVE OIL PHENOLS MODULATE THE EXPRESSION OF METALLOPROTEINASE 9 IN A MONOCYTIC CELL LINE BY ACTING ON NF-KB SIGNALLING

2009 ◽  
Vol 10 (2) ◽  
pp. e1466
Author(s):  
M Dell'Agli ◽  
R Fagnani ◽  
G Galli ◽  
O Maschi ◽  
F Gilardi ◽  
...  
Keyword(s):  
Olive Oil ◽  
Cell Line ◽  
Monocytic Cell ◽  
Monocytic Cell Line ◽  
Metalloproteinase 9

Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque

2005 ◽  
Author(s):  
Fei Chen ◽  
Per Eriksson ◽  
Göran Hansson ◽  
Istvan Herzfeld ◽  
Magareta Klein ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Atherosclerotic Plaque ◽  
Metalloproteinase 9

Olive Oil Phenols Modulate the Expression of Metalloproteinase 9 in THP-1 Cells by Acting on Nuclear Factor-κB Signaling

2010 ◽  
Vol 58 (4) ◽  
pp. 2246-2252 ◽  
Author(s):  
Mario Dell’Agli ◽  
Rossana Fagnani ◽  
Germana V. Galli ◽  
Omar Maschi ◽  
Federica Gilardi ◽  
...  
Keyword(s):  
Olive Oil ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 expression in carotid atherosclerotic plaque and contrast-enhanced MRI in a swine model

2012 ◽  
Vol 6 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Xiao-Bing Jiang ◽  
Wei-Si Yuan ◽  
Jin-Shan Wang ◽  
Zhong Liu ◽  
Dong-Hong Liu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Matrix Metalloproteinase 9 ◽  
Swine Model ◽  
Carotid Atherosclerotic Plaque ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Metalloproteinase 9 ◽  
Contrast Enhanced Mri
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