Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
C Waterman ◽  
DM Cheng ◽  
P Rojas-Silva ◽  
A Poulev ◽  
J Dreifus ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Moringa Oleifera Leaves ◽  
Water Extractable

scholarly journals Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

2014 ◽  
Vol 103 ◽  
pp. 114-122 ◽  
Author(s):  
Carrie Waterman ◽  
Diana M. Cheng ◽  
Patricio Rojas-Silva ◽  
Alexander Poulev ◽  
Julia Dreifus ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Moringa Oleifera Leaves ◽  
Water Extractable

scholarly journals Aggregatibacter actinomycetemcomitans sensitivity towards chlorophyll of Moringa leaf after activated by diode laser

2016 ◽  
Vol 49 (4) ◽  
pp. 195
Author(s):  
I Gde Bagus Yatna Wibawa ◽  
Suryani Diah Astuti ◽  
Ernie Maduratna Setiawati
Keyword(s):  
Energy Density ◽  
Diode Laser ◽  
Moringa Oleifera ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Photodynamic Inactivation ◽  
Absorption Of Light ◽  
Long Time ◽  
Moringa Oleifera Leaves ◽  
Root Planning

Background: Regular brushing teeth with scaling and root planning (SRP) cannot effectively decrease the periopatogen bacterial colonies. Even with the addition of antibiotics to support SRP, such as tetracycline given with low doses and for a long time may cause bacteria to become resistant and the effectiveness to eliminate colonies of bacteria being reduced. Photodynamic is a treatment modality that does not cause resistance and potentially to eliminate the growth of bacterial colonies. Moringa oleifera is a plant that can be easily found in Indonesia, by extracting chlorophyll of Moringa oleifera leaves, it can be used as a photosensitizer agent to increase the absorption of light on photodynamic method. Purpose: This study aimed to determine the potential photodynamic inactivation therapy to inactivate (eliminate) periopatogen bacterium. Method: This study used Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). Laser diode 660nm as a light source with 8mm optical fiber to guide the beam, also used 20% extract chlorophyll of Moringa oleifera leaf as photosensitizer. Four diode lasers energy density exposures (2,5J.cm-2, 5J.cm-2, 7,5J.cm-2, and 10J.cm-2) are used from both at the in vitro photodynamic inactivation test. Result: The highest percentage of deaths occurred in the group treated with addition of photosensitizer and exposed by 660 nm diode laser with 10J.cm-2 energy density, which is 83.01%, compared to the results obtained in the group without addition of the photosensitizer. Conclusion: Chlorophyll of Moringa oleifera leaf after activated by diode laser effectively eliminates A. actinomycetemcomitans.

scholarly journals Optimization of Phenolic Compound Extraction from Chinese Moringa oleifera Leaves and Antioxidant Activities

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Beibei Zhao ◽  
Jiawen Deng ◽  
Hua Li ◽  
Yaqiang He ◽  
Tao Lan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Moringa Oleifera ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Ultrasonic Extraction ◽  
Extraction Temperature ◽  
Moringa Oleifera Leaves

Rich in phenolic compounds, Moringa oleifera leaf extract (ME) exhibits significant antioxidant activity both in vitro and in vivo. ME has already been widely used in fields of medicine, functional food, and cosmetics. Ultrasonic extraction (UE) method has been improved to be one of the most effective ways to extract phenols from M. oleifera leaves. The purpose of this study was to optimize ultrasonic extraction of phenols by response surface methodology (RSM). Four parameters were discussed, such as ethanol concentration, solvent-sample ratio, extraction temperature, and extraction time. Also, purification methods of the crude ME by organic solvent extraction and column chromatography were examined. Antioxidant activities of ME and each fraction were evaluated by DPPH, ABTS, and hydroxy radical-scavenging activities and reducing power. The phenol content of the purified ME reached up to 962.6 mg RE/g, extremely higher than the crude extract 107.22 ± 1.93 mg RE/g. The antioxidant activity of the purified ME was also significantly improved. Furthermore, phenols were identified by using the HPLC-MS method, and the results showed that there were 6 phenolic acids and derivatives and 7 flavonoids in ME. Quercetin-3-O-β-D-glucoside isolated from ME showed excellent DPPH and ABTS radical-scavenging abilities, which were comparable to VC.

scholarly journals A Comparative HPLC Analysis of Myricetin, Quercetin and Kaempferol Flavonoids Isolated From Gambian and Indian Moringa oleifera Leaves

2018 ◽  
Vol 10 (4) ◽  
pp. 28 ◽  
Author(s):  
Leroy A. Shervington ◽  
Bianca Szeaar Li ◽  
Amal A. Shervington ◽  
Nsima Alpan ◽  
Ronak Patel ◽  
...  
Keyword(s):  
High Performance ◽  
Moringa Oleifera ◽  
Method Development ◽  
Community Forest Management ◽  
Significant Difference ◽  
Moringa Oleifera Leaves ◽  
High Yields ◽  
Geographical Locations

Moringa oleifera has been used for centuries as a traditional medicine in a number of sub-tropical countries. Recent studies have found it to be rich in flavonoids that exhibit antioxidant activity both in vitro and in vivo. In this study slightly modified conditions were examined in order to maximise the yield of these compounds in particular; Myricetin, Quercetin and Kaempferol. Quantitative analysis of these flavonoids were established using reverse phase ion-pairing High Performance Liquid Chromatography (HPLC) at a wavelength of 370 nm. The method development was carried out following the International Conference for Harmonization guidelines. It was found that refluxing with 0.10 M hydrochloric acid for 24 hour provided high yields of the flavonols (myricetin 292 mg/kg, quercetin 1099 mg/kg and kaempferol 133 mg/kg). There was a significant difference in the yield of these flavonols originating from the different geographical locations, with Community Forest Management Farm (CFM Farm) yielding the highest quantity of the flavonols under the conditions applied.

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