Characterization of Unfractionated Heparin: Comparison of Materials from the last 50 Years

2000 ◽  
Vol 84 (12) ◽  
pp. 1052-1056 ◽  
Author(s):  
Elaine Gray ◽  
Trevor Barrowcliffe ◽  
Barbara Mulloy

SummaryPhysicochemical and anticoagulant characteristics of 27 samples from recent batches of commercially produced unfractionated heparin have been determined as part of the process of establishment of the 5th International Standard Unfractionated Heparin. They have been compared with current heparin standards (European Pharmacopoeia, United States Pharmacopoeia, Chinese), with the 4th International Standard Unfractionated Heparin, and with the three predecessor International Standards. The results indicate that the 4th International Standard Unfractionated Heparin, established in 1982, has significantly lower molecular weight and specific activity than recently produced heparin; this is also true of all preceding International Standard Heparins and of the United States Pharmacopoeial standard. The composition of commercial unfractionated heparin may therefore have changed over time; reasons for this are discussed.

2021 ◽  
Author(s):  
◽  
Margaret Nell Galt

<p>This thesis examines the level and distribution of wealth and income in New Zealand between about 1870 and 1939. To do so it draws upon the available aggregate statistics on wealth and income, and it uses a sample of wealth holders especially constructed to alleviate the data deficiencies which have arisen through New Zealand not having a wealth census. The evidence available suggests that New Zealand was correctly portrayed as having a high level of wealth with an egalitarian distribution. In 1893, the first year in which average wealth could be estimated, New Zealand was definitely wealthier than Victoria. This wealth was not evenly distributed but the gini coefficient of about 0.75 suggested that New Zealand was an egalitarian economy compared to the United States, Britain, or even Australia. Over the period to 1939 the average level of wealth increased by about 100 percent. Most of this increase took place between 1900 and 1922; the late 1920's and 1930's were periods of slow growth. But this increase was not sufficient to maintain New Zealand's high position relative to Australia, and probably to other countries. The growth of real wealth was accompanied by a redistribution of wealth and by the 1930's, the gini coefficient was only about 0.73. Most of this decline was due to the declining assets held by the very rich. In 1890 to 1895 the top one percent of wealth holders owned 55 - 60 percent of all assets, but by 1935 to 1939 this had fallen to 25 - 30 percent. The very rich had, in fact, never been rich by international standards. The case studies in the thesis did not include one millionaire. As a rule they were first generation wealthy men who came from a well-to-do background, who had superior education, but who had to achieve being wealthy through their own efforts. There were few women among the top wealth holders, and those who did appear inherited their wealth from their father or or husband. The wealthy did not show signs of being a closed elite. There was a considerable amount of upward mobility in the group, and the Scots especially tended to come from poor backgrounds. The practise of equal inheritance among all the children meant that few families remained very wealthy for more than one generation. The same social and occupational mobility was clear among our sample of estate holders. Only 50 percent of sons had the same social status as their fathers. The remaining sons were fairly evenly divided between those who rose and those who fell in status. The sample, which was constructed from probate valuations and death certificate records, suggests some of the factors which assisted and hindered upward mobility. Being born female at a time when women did not pursue careers, or own family property obviously influenced the wealth holdings of a considerable proportion of the population. For men, the place of their birth proved to be significant. The Scottish showed a marked tendency to be upwardly mobile, while being Irish or New Zealand born was a definite handicap. Those who were born overseas did better if they arrived as young adults between 1860 and 1880. Assisted migrants produced proportionately less probatable estates, but those who did had about the same estates as those not assisted. Wealth was concentrated among those involved in farming, trading and the professions throughout most of our period, but over time agricultural wealth showed signs of being replaced by industrial fortunes. The professions had the advantage of a comparatively high income which enabled people to accumulate fortunes. Lifetime income undoubtedly had the major influence on wealth at death. The level of average income increased probably three-fold in the period. Again most of this rise came between 1900 and 1920. It is probable that the distribution also became more equal, through the reduced incomes to the top earners. There was a strong trend for margins for skill to decline over time, even though they were already small relative to those found in the United States. The exception to this was teachers' salaries, which showed a marked rise as the occupation became more professional. The rise of teachers' wages, shop work and clerical jobs all changed the employment structure for women, which was reflected in a changed attitude towards higher education. The 1930's saw a reduction in incomes largely through unemployment and short-time. However, the reduction was heaviest among those in the top 10 percent. The depression had mixed effects on production levels, prices and wages, but only one of our three sample industries, butter and cheese making, showed strong evidence of wage overhang. In 1939 New Zealand was still a wealthy nation, though probably she would not have ranked as highly on an international scale as in 1890. The distribution of both wealth and income had changed over our period to being substantially more egalitarian.</p>


Author(s):  
HERMAN SURYADI ◽  
SUTRIYO ◽  
Mira Junnisa ◽  
YULIANITA PRATIWI INDAH LESTARI

Objective: This study aimed to find psychochemical properties of microcrystalline cellulose (MCC) obtained from α-cellulose kapok pericarpium. Methods: The cellulase activity was screened by clear zone and sugar reduction method. The enzym from selected mold was purified by diethylaminoethyl (DEAE) chromatography. α-cellulose of kapok pericarpium was hydrolyzed using the purified cellulase enzymes. Microcrystalline cellulose (MCC) identified by Fourier transform infrared (FTIR) spectrometry, and qualitative analysis test. The samples were characterized for pH test, x-ray diffraction (XRD), and particle size analyzer (PSA). Results: The optimum cellulase activity was shown by Penicillium vermiculatum. It’s clear zone diameter around 3 cm and the cellulase activity was 67.73±0.25 mU/ml. The strongest cellulase activity was detected from 1st fraction (P1) out of 6 column fractions with optimum activity at 1.177±2 mU/ml. The optimal conditions for microcrystalline cellulose (MCC) preparation were at 50 ˚C, for 2 ours, using 20 ml of acetate buffer pH 5 and 2 ml of cellulase enzyme. Microcrystalline cellulose (MCC) obtained at 78% w/w and its FTIR spectrum and x-ray diffractogram similar to reference while the pH of MCC was fulfilled requirements of The United States Pharmacopoeia 2007. Conclusion: The use of purified enzyme of cellulase has succeded in microcrystalline cellulose (MCC) preparation andmicrocrystalline cellulose (MCC) obtained was 78% w/w, with similar characteristics to reference (Avicel PH 101) and the pH of MCC was fulfilled requirements of The United States Pharmacopoeia 2007.


2021 ◽  
Author(s):  
◽  
Margaret Nell Galt

<p>This thesis examines the level and distribution of wealth and income in New Zealand between about 1870 and 1939. To do so it draws upon the available aggregate statistics on wealth and income, and it uses a sample of wealth holders especially constructed to alleviate the data deficiencies which have arisen through New Zealand not having a wealth census. The evidence available suggests that New Zealand was correctly portrayed as having a high level of wealth with an egalitarian distribution. In 1893, the first year in which average wealth could be estimated, New Zealand was definitely wealthier than Victoria. This wealth was not evenly distributed but the gini coefficient of about 0.75 suggested that New Zealand was an egalitarian economy compared to the United States, Britain, or even Australia. Over the period to 1939 the average level of wealth increased by about 100 percent. Most of this increase took place between 1900 and 1922; the late 1920's and 1930's were periods of slow growth. But this increase was not sufficient to maintain New Zealand's high position relative to Australia, and probably to other countries. The growth of real wealth was accompanied by a redistribution of wealth and by the 1930's, the gini coefficient was only about 0.73. Most of this decline was due to the declining assets held by the very rich. In 1890 to 1895 the top one percent of wealth holders owned 55 - 60 percent of all assets, but by 1935 to 1939 this had fallen to 25 - 30 percent. The very rich had, in fact, never been rich by international standards. The case studies in the thesis did not include one millionaire. As a rule they were first generation wealthy men who came from a well-to-do background, who had superior education, but who had to achieve being wealthy through their own efforts. There were few women among the top wealth holders, and those who did appear inherited their wealth from their father or or husband. The wealthy did not show signs of being a closed elite. There was a considerable amount of upward mobility in the group, and the Scots especially tended to come from poor backgrounds. The practise of equal inheritance among all the children meant that few families remained very wealthy for more than one generation. The same social and occupational mobility was clear among our sample of estate holders. Only 50 percent of sons had the same social status as their fathers. The remaining sons were fairly evenly divided between those who rose and those who fell in status. The sample, which was constructed from probate valuations and death certificate records, suggests some of the factors which assisted and hindered upward mobility. Being born female at a time when women did not pursue careers, or own family property obviously influenced the wealth holdings of a considerable proportion of the population. For men, the place of their birth proved to be significant. The Scottish showed a marked tendency to be upwardly mobile, while being Irish or New Zealand born was a definite handicap. Those who were born overseas did better if they arrived as young adults between 1860 and 1880. Assisted migrants produced proportionately less probatable estates, but those who did had about the same estates as those not assisted. Wealth was concentrated among those involved in farming, trading and the professions throughout most of our period, but over time agricultural wealth showed signs of being replaced by industrial fortunes. The professions had the advantage of a comparatively high income which enabled people to accumulate fortunes. Lifetime income undoubtedly had the major influence on wealth at death. The level of average income increased probably three-fold in the period. Again most of this rise came between 1900 and 1920. It is probable that the distribution also became more equal, through the reduced incomes to the top earners. There was a strong trend for margins for skill to decline over time, even though they were already small relative to those found in the United States. The exception to this was teachers' salaries, which showed a marked rise as the occupation became more professional. The rise of teachers' wages, shop work and clerical jobs all changed the employment structure for women, which was reflected in a changed attitude towards higher education. The 1930's saw a reduction in incomes largely through unemployment and short-time. However, the reduction was heaviest among those in the top 10 percent. The depression had mixed effects on production levels, prices and wages, but only one of our three sample industries, butter and cheese making, showed strong evidence of wage overhang. In 1939 New Zealand was still a wealthy nation, though probably she would not have ranked as highly on an international scale as in 1890. The distribution of both wealth and income had changed over our period to being substantially more egalitarian.</p>


2010 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
Emily G. Cantonwine ◽  
Albert K. Culbreath ◽  
Robert C. Kemerait ◽  
Ronald D. Gitaitis

Irregular leaf spot (ILS) of peanut was first noticed in Florida during the late 1990s. By 2000, ILS was apparent throughout much of the southeastern peanut growing region of the United States. Experiments were conducted to identify the cause of ILS, characterize ILS development over time, and evaluate the effect of genotype, tillage, and applications of fungicides and bactericides on ILS. Severities of ILS were near maximum levels at 33 to 42 days after planting (DAP) and in decline by 56 DAP. Incidence of ILS was greater in the lower canopy than the upper canopy. In most cases, ILS intensities were greater in strip-tilled plantings than conventional-tilled plantings and in the peanut breeding line UF-99325 than the cultivar Georgia Green. No fungicide or bactericide treatment suppressed ILS intensity. Attempts to isolate pathogenic fungi or bacteria from ILS lesions were unsuccessful. Although a pathogen cannot be totally dismissed as the cause of ILS, it is likely that ILS is caused by an abiotic factor. Accepted for publication 17 May 2010. Published 27 July 2010.


2007 ◽  
Author(s):  
Karen A. Fitzner ◽  
Charlie Bennett ◽  
June McKoy ◽  
Cara Tigue

Author(s):  
William W. Franko ◽  
Christopher Witko

The authors conclude the book by recapping their arguments and empirical results, and discussing the possibilities for the “new economic populism” to promote egalitarian economic outcomes in the face of continuing gridlock and the dominance of Washington, DC’s policymaking institutions by business and the wealthy, and a conservative Republican Party. Many states are actually addressing inequality now, and these policies are working. Admittedly, many states also continue to embrace the policies that have contributed to growing inequality, such as tax cuts for the wealthy or attempting to weaken labor unions. But as the public grows more concerned about inequality, the authors argue, policies that help to address these income disparities will become more popular, and policies that exacerbate inequality will become less so. Over time, if history is a guide, more egalitarian policies will spread across the states, and ultimately to the federal government.


2014 ◽  
Vol 35 (4) ◽  
pp. 423-425 ◽  
Author(s):  
Edwin C. Pereira ◽  
Kristin M. Shaw ◽  
Paula M. Snippes Vagnone ◽  
Jane E. Harper ◽  
Alexander J. Kallen ◽  
...  

Carbapenem-resistant Enterobacteriaceae (CRE) are a growing problem in the United States. We explored the feasibility of active laboratory-based surveillance of CRE in a metropolitan area not previously considered to be an area of CRE endemicity. We provide a framework to address CRE surveillance and to monitor changes in the incidence of CRE infection over time.


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