DECREASED PROSTACYCLIN-LIKE ACTIVITY IN HENOCH-SCHONBEIN PURPURA

1987 ◽  
Author(s):  
J J F Belch ◽  
S Turi ◽  
M MacLaren ◽  
T J Beattie ◽  
C D Forbes
Keyword(s):  
Platelet Rich Plasma ◽  
Skin Lesions ◽  
Endothelial Damage ◽  
Common Type ◽  
Intestinal Involvement ◽  
Childhood Vasculitis ◽  
The Difference ◽  
Umbilical Arteries ◽  
And Control

Henoch-Schoniein purpura (HSP) is the most common type of childhood vasculitis. The skin lesions are the most obvious sign but visceral involvement carries a more serious prognosis. Increasing amounts of data are available regarding the possible role of prostacyclin (PGI2) in the pathogenesis of other vasculo-pathies, but no-one has previously investigated HSP. 17 HSP patients (mean age (SD) 5.7 (2.5) years) and 17 matched controls were studied. The ability of plasma (patient and control) to support PGI2 -like activity was tested. Human umbilical arteries were chopped into rings and incubated in buffer at 37° C. Aliquots of the supernatant were added to platelet rich plasma (PRP) and platelet aggregation measured (Malin's aggregometer). Repeated washings of the rings then depleted PGI. production. The rings were then incubated with test platelet poor plasma (PPP) at 37° C. PGI2 like activity was assessed as before and the results expressed as a percentage of the aggregation obtained by the same exhausted ring before addition of PPP. The results show that the ability of test PPP to support PGI2 like activity was reduced in 13/17 HSP patients. The difference between patients (21.3 (SD 20.5%) and controls (57.2 (SD 12.2%) was significant (p<0.001). Patients with renal and gastro-intestinal involvement (7.5 (SD 18.1%) were significantly different from those patients with only skin involvement (32.3 (SD 23.5%) (p<0.01). Plasma from six patients in which PGI^like activity was undetectable using the above method were further studied to detect PGI2 -inhibitory activity. Unexhausted umbilical rings were incubated at 37°C for 5mins. The baseline PGI2 like activity of the supernatant was compared with that produced after 5mins. incubation with test PPP (o patients, 6 controls). Less like activity was produced by the unexhausted rings when incubated with PPP from the HSP patients than with either control buffer or control PPP (both p<0.01). It seems likely that these abnormalities, having been demonstrated in yet another vasculitic syndrome, are secondary to endothelial damage. The disturbances, however, may well be of importance in extending the primary microvascular insult

scholarly journals FOREIGN CONTROL PRACTICE AND PROBLEMS OF ITS IMPLEMENTATION AT NATIONAL ENTERPRISES

2021 ◽  
pp. 19-27
Author(s):  
Volodimir Mishchenko ◽  
Sergey Mekhovych ◽  
Irina Gorobets
Keyword(s):  
Information Support ◽  
Planning System ◽  
Control Practice ◽  
Controlling System ◽  
Innovative Tool ◽  
The Difference ◽  
Foreign Control ◽  
And Control ◽  
Role Of Information

The article describes the essence of controlling and its necessity in modern conditions. The difference between it and control is shown. The coordinating tasks of the controller are highlighted. The system of controlling operational planning on the example of foreign concerns is considered. Business planning and implementation of the controlling system are described. The role of information support of the planning system is emphasized. Reflective factors of restraint of controlling introduction at the enterprises of food branch are reflected. Examples of effective application of this innovative tool at separate national enterprises are given. The starting possible ways of introduction of controlling at the confectionery enterprises are defined.

scholarly journals The Role of Volume, Conductivity, Scatter Changes of Neutrophils and Monocytes in Diagnosis of Megaloblastic Anemia

2020 ◽  
Vol 7 (12) ◽  
pp. A563-569
Author(s):  
Deepa Sowkur Anandarama Adiga ◽  
Debarshi Saha ◽  
Karthick R G ◽  
Vishnu Priya M ◽  
Purnima S Rao ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Serum Vitamin ◽  
Volume Conductivity ◽  
Degree Of Certainty ◽  
Normochromic Anemia ◽  
The Mean ◽  
The Difference ◽  
And Control

Background: Megaloblastic anemias are macrocytic normochromic anemia with mean corpuscular volume (MCV) of 100 fl-140 fl and caused by deficiency of either cobalamin (vitamin B12) or folate. However, increased MCV is not specific for megaloblastic anemia, nor is Vitamin B12 assay by chemiluminescence. We undertook this study to evaluate the possible role of Volume, Conductivity and Scatter (VCS) of WBCs derived from standard hematology analyzer to indicate megaloblastic anemia. Methods: We performed a case control study comparing data of 60 patients with low serum vitamin B12 or folate levels with 60 healthy volunteers. Comparison of the volume, conductivity and scatter parameters for neutrophils and monocytes of cases and control were done. Result: The mean neutrophil volume of cases (158.37±18.13fl) was significantly higher (p= 0.0001) compared to controls (141.26±4.22fl). Similarly, mean monocyte volume of cases (183.34±16.90fl) was significantly (p=0.0001) higher compared to controls (166.55±8.66fl). The difference in the mean conductivity of both neutrophils and monocytes between cases and controls were insignificant (p=0.43). Conclusion: Our study suggests analysis of VCS parameters for neutrophils and monocytes was a simple and objective method that substantiates the existence of subclinical deficiency of vitamin B 12 and folate with fair degree of certainty.

scholarly journals Aware Migrants: The role of information campaigns in the management of migration

2019 ◽  
Vol 34 (6) ◽  
pp. 629-640 ◽  
Author(s):  
Pierluigi Musarò
Keyword(s):  
Specific Information ◽  
Information Campaign ◽  
Information Campaigns ◽  
Italian Government ◽  
Starting Point ◽  
The Us ◽  
The Difference ◽  
And Control ◽  
Role Of Information

Taking as a starting point studies on the biopolitics of bordering, as well as media studies, this article explores how information campaigns deter potential migrants and refugees from leaving their countries depict them in very specific ways, operating as ‘new bordering practices’ that are in conjunction with extraterritorial border policies. This article probes this question through the example of a specific information campaign – Aware Migrants (2016) – funded by the Italian Government and managed by International Organization for Migration (IOM) to dissuade potential newcomers from attempting the journey across the Mediterranean Sea. As the analysis of Aware Migrants makes clear, it contributes to normalizing a transnational imaginary into a militarized borderscape comprising places of violence and death, exploitation and detention, which is part of the complex dichotomies of care and control, proper of contemporary border regimes. Finally, the article sheds light on how these symbolic bordering practices contribute to nurturing a ‘compassionate repression’ that increasingly and silently legitimizes the difference between the ‘us’ (the figure of the citizen) and the ‘them’ (the figure of the foreigner).

Epidemic Bullous Impetigo in a Nursery Due to a Nasal Carrier of Staphylococcus aureus: Role of Epidemiology and Control Measures

1984 ◽  
Vol 5 (7) ◽  
pp. 326-331 ◽  
Author(s):  
Allyn K. Nakashima ◽  
James R. Allen ◽  
William J. Martone ◽  
Brian D. Plikaytis ◽  
Beth Storer ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Phage Type ◽  
Skin Lesions ◽  
Control Measures ◽  
Epidemic Strain ◽  
Nasal Carrier ◽  
Infection Control Measures ◽  
Epidemic Period ◽  
And Control

AbstractFrom September 14, 1981 to February 28, 1982, an epidemic of bullous impetigo caused by a penicillin/tetracycline resistant strain of Staphylococcus aureus, phage type 3A/3C, occurred in a newborn nursery in Louisville, Kentucky. Twenty of 1,181 (1.7%) infants at risk developed disease during the six-month epidemic period. Clinically all case-infants had bullous impetigo skin lesions. One infant developed staphylococcal septicemia. No infant died. An epidemiologic investigation identified a nurse as having significantly greater contact with case-infants than control-infants (p=0.0013). She was also found to be a nasal carrier of the epidemic strain. Infection control measures appeared to decrease infant-to-infant transmission via the hands of non-colonized nurses, but did not affect transmission from the nurse carrying the epidemic strain to infants. No cases of bullous impetigo have occurred since this nurse was temporarily removed from the nursery for treatment.

scholarly journals Relationship between the difference in electric pulp test values and the diagnostic type of pulpitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Huachao Sui ◽  
Yangyang Lv ◽  
Mo Xiao ◽  
Liwen Zhou ◽  
Feng Qiao ◽  
...  
Keyword(s):  
Dental Caries ◽  
Anterior Teeth ◽  
Crude Model ◽  
Predictive Probability ◽  
Age Model ◽  
Tooth Type ◽  
The Difference ◽  
Diagnosis Criteria ◽  
And Control

Abstract Background According to the diagnosis criteria of the American Association of Endodontists (AAE), sensitive responses to cold and/or heat tests of suspected teeth compared with those of control teeth can be used for the diagnosis of pulpitis, but the role of electric pulp test (EPT) is not mentioned. It is believed that EPT has some limitations in determining the vitality of the pulp. The aim of this study was to explore the association between the difference in EPT values and the differential diagnoses of reversible pulpitis (RP) and symptomatic irreversible pulpitis (SIRP) caused by dental caries. Methods A total of 203 cases with pulpitis caused by dental caries were included. A diagnosis of pulpitis was made on the basis of the diagnostic criteria of AAE. Patient demographic and clinical examination data were collected. The EPT values of the suspected teeth and control teeth were measured, and the differences between them were calculated. The correlation between the difference in the EPT values and diagnosis of pulpitis was analyzed using univariate and multivariate logistic regression. Results In the 203 cases (78 males and 125 females; 115 cases of RP, 88 cases of SIRP; 9 anterior teeth, 59 premolars, and 135 molars), the mean patient age was 34.04 ± 13.02 (standard deviation) years. The unadjusted (crude) model, model 1 (adjusted for age), model 2 (adjusted for age and sex), and model 3 (adjusted for age, sex, and tooth type) were established for the statistical analyses. In model 3 [odds ratio (OR) = 1.025; 95% confidence interval (CI) 1.002–1.050; P = 0.035], the difference in EPT values between RP and SIRP was statistically significant. However, the areas under the curve of predictive probability of the crude model, model 1, model 2, and model 3 were 0.565, 0.570, 0.585, and 0.617, respectively, showing that the model accuracy was low. The P-value for the trend in differences between the EPT values as a categorical variable showed that the differences in the EPT values, comparing RP and SIRP, were not statistically significant. Conclusions Based on the present data, the difference in EPT values was not sufficient to differentiate RP from SIRP.

scholarly journals Peran Kepuasan Wajib pajak Sebagai Pemediasi Atas Pelayanan Fiskus Terhadap Kepatuhan Wajib Pajak

2018 ◽  
Vol 5 (1) ◽  
pp. 24-38
Author(s):  
Samsul Bahri ◽  
Syahril Djaddang ◽  
Tri Widyastuti
Keyword(s):  
Raw Materials ◽  
Infrastructure Development ◽  
Private Companies ◽  
Planning And Control ◽  
Maximum Value ◽  
The Difference ◽  
And Control ◽  
Construction Services ◽  
Project Company

Increasingly rapid economic development resulted in many new companies springing up and creating a tight business competition. To be able to maintain business continuity, companies must be able to make a careful planning and control of the costs. Planning and control can be realized with the budget as a mean of control. Controlling costs by the company are intended to enable companies to minimize costs. At minimal costs the company will be able to achieve the profit target by more optimal as primary destinations in general. In connection to this, the purpose of this study was to determine the costs of the company budget preparation, budget realization costs and revenues, as well as the role of the budget as a mean of control in achieving its profit target. The research was conducted at PT ABC located in Bogor. PT ABC is one of the private companies engaged in construction services focusing on building the types of housing. This kind of development focus includes the construction of a building without infrastructure development. The study of PT ABC shows that the preparation of the company's budget is based on field survey and accompanying informations on the revenue budget and previous projects. In the implementation of the work there was an increase in the actual cost, thus resulting difference in the budget and actual costs. The occurrence of this difference will reduce the company’s profits. Overall budgets have created optimal control of the realization of the costs incurred. Budget serves as guidelines and benchmarks maximum value in any cost incurred by the company. However, in the implementation of the work there are still some shortcomings, resulting cost difference persists. This difference occurs because lack of oversight of the usage of raw materials. Companies must be able to improve control over the using of raw materials to be better coordinated. Increased control is evidenced by the increase in its profit target achievement on the next project. In the subsequent project, company managed to improve the performance of surveillance so that the difference in costs declined and its optimal profit target can be achieved.

scholarly journals Social preference in rats not impacted by posterior parietal activity despite overall changes in familiarity-based social behavior

2021 ◽  
Author(s):  
Taylor B. Wise ◽  
Rebecca D. Burwell ◽  
Victoria L. Templer
Keyword(s):  
Social Behavior ◽  
Posterior Parietal Cortex ◽  
Social Preference ◽  
Novelty Preference ◽  
Potential Link ◽  
Posterior Parietal ◽  
The Difference ◽  
Neurotoxic Lesions ◽  
And Control

Recent literature points to a potential link between the evolution of complex social behavior and the posterior parietal cortex (PPC) in primates including humans (Parkinson & Wheatley, 2013). Thus far, this theory has been overlooked in other highly social animals that may have also evolved due to social selective pressures. In rodents, there is limited knowledge on the involvement of the PPC on sociality, and most studies of such behavior are limited to understanding social preference. We investigated the role of the PPC through two experiments using the 3-Chamber Sociability and Social Novelty test in rats (Crawley, 2004). In Experiment 1, we used a standard 3-Chamber paradigm, which included two novel demonstrators. In Experiment 2, this paradigm was altered to increase the difference in familiarity between demonstrators such that one demonstrator was highly familiar to the subject and the other was entirely novel. Rats with pre-testing permanent neurotoxic lesions were compared to sham surgery control rats, and the same rats were used for both experiments. Experiments 1 and 2 showed that both groups of rats preferred general social interaction, suggesting no deficit in sociability following PPC damage, regardless of demonstrator identity. Further, experimental and control rats showed similar levels of novelty preference following PPC damage, with novelty preferences increasing in Experiment 2. We argue that heightened novelty preference in Experiment 2 may reflect the increased difference in familiarity between demonstrators. Within the confines of the 3-Chamber task, our results suggest that PPC function was not required for general sociability or social novelty recognition. Because the PPC is implicated in abstract cognition, we argue that existing social tests in rodents may not adequately measure the complex cognitive capacities thought to be supported by the PPC. Future studies should investigate the role of the PPC in social cognition by employing behavioral tasks that require higher cognitive demand rather than testing inherent preference for social partners. Outside of our investigation of the PPC, these results show that social novelty preference can be manipulated through changes in familiarity of demonstrators, and that rats can discriminate others social identities.

scholarly journals Effect of Platelet-rich Plasma on Implant Stability in the Mandible

2018 ◽  
Vol 7 (2) ◽  
pp. 50-54
Author(s):  
Mohammad Ketabi ◽  
Narges Fahami ◽  
Shahram Amini
Keyword(s):  
Oral Surgery ◽  
Platelet Rich Plasma ◽  
Test Group ◽  
Mental Foramen ◽  
Control Group ◽  
Implant Stability ◽  
Implant Surface ◽  
The Difference ◽  
Edentulous Patients ◽  
And Control

Background and aims. Plasma rich in growth factors (PRGFs) has been recently proposed as an aid to enhance regeneration of osseous and epithelial tissues in oral surgery. The purpose of this study was to determine the effect of local application of platelet-rich plasma (PRP) on implant stability measured by periotest. Materials and methods. A total of 24 implants were placed in the mandibles of 12 lower edentulous patients. In each patient, 2 implants were placed anterior to the mental foramen in bilateral canine sites. One implant in each patient was dipped in autogenous PRP before insertion (test group), while the other implant was not embedded in PRP (control group). Repeated stability measurements were carried out by periotest on the day of surgery and 1, 2, 4 and 8 weeks after surgery. Results. In both groups minimum periotest values (highest stability) were observed on the day of surgery and 8 weeks after surgery. The maximum periotest values (lowest stability) were observed in 4th week after surgery. Considering implant stability, no statistically significant differences were observed between the test and control groups at any time (P>0.05). In the PRP group, the difference in implant stability between the day of surgery and the 2nd and 4th weeks were statistically significant (P<0.05). Conclusion. Application of PRP on implant surface did not have any additional effect on implant stability in the mandible

Voice

2017 ◽  
pp. 147-168
Author(s):  
Gian Maria Annovi
Keyword(s):  
Epistemic Authority ◽  
Vocal Performance ◽  
High Priest ◽  
Fictional Narrative ◽  
Voice Changes ◽  
Homophobic Violence ◽  
The Difference ◽  
And Control

Chapter six discusses the effects produced by Pasolini’s vocal performance in his films. Pasolini’s voice changes according to the function attributed to his authorial presence. It is his real voice when he presents himself as the author, as in film experiments such as Appunti per un’Orestiade Africana (Notes Toward an African Orestes, 1970) and Comizi d’amore (Love Meetings, 1963). However, when he plays a character in a fictional narrative, as in the case of The Trilogy of Life, his voice is dubbed. In this chapter I examine the difference between these two kinds of voice, showing that also dubbing and voiceover are elements of the performance of Pasolini’s authorship. I focus particularly on dubbing in Edipo re (Oedipus Rex, 1967), where Pasolini played the apparently marginal role of the High Priest. Pasolini’s use of his actual voice, as in the case of the voiceover in La sequenza del fiore di carta (The Sequence of the Paper Flower, 1969) and La Ricotta shows the author’s epistemic authority and control over the interpretation of his work. He particularly emphasizes the importance of his vocal performance in Love Meetings, a cinéma vérité experiment in which he interviews Italian people of all kind on issues concerning sexuality. However, when the questions turn to homosexuality, Pasolini silences his own voice (and authority), in order to reveal the homophobic violence of 1960s Italian society, unfiltered. Pasolini’s silence thus produces a subtle and subversive homopolitical intervention, which anticipates the more militant and strategic use of homosexual desire in The Trilogy of Life.

scholarly journals The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Zebrowska Agnieszka ◽  
Erkiert-Polguj Anna ◽  
Wagrowska-Danilewicz Malgorzata ◽  
Danilewicz Marian ◽  
Sysa-Jedrzejowska Anna ◽  
...  
Keyword(s):  
Fas Ligand ◽  
Dermatitis Herpetiformis ◽  
Single Cells ◽  
Skin Lesions ◽  
Control Group ◽  
Trail Expression ◽  
Skin Biopsies ◽  
And Control ◽  
Perilesional Skin

The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry. Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients. Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts. The expression of examined molecules in biopsies from healthy people was observed only in single cells. There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression. There were statistically significant differences between control group and perilesional skin in Bax and FasL expression. Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear.

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