FV 658. Cognitive Impairment, Depression, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis: Results of the Multiple Sclerosis Inventory of Cognition in ADOlescents Study

Cognitive impairment in multiple sclerosis

British Journal of Neuroscience Nursing ◽

10.12968/bjnn.2021.17.sup1.s16 ◽

2021 ◽

Vol 17 (Sup1) ◽

pp. S16-S22

Author(s):

Jennifer Slough ◽

Wallace Brownlee

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Cognitive Tests

Cognitive impairment is a common but under-diagnosed symptom in people with multiple sclerosis (MS). Cognitive impairment is important to consider as it can have a big impact on quality of life (QoL) for people with MS and, although easily identified in clinic with simple cognitive tests, these are not routinely done. From a nursing perspective, it is important to be aware of how to manage cognitive impairment in MS. Jennifer Slough and Wallace Brownlee explain.

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Validity and Reliability of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in Indonesia and the Correlation with Quality of Life

Neurology Research International ◽

10.1155/2019/4290352 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7

Author(s):

Riwanti Estiasari ◽

Yuhyi Fajrina ◽

Diatri Nari Lastri ◽

Syarli Melani ◽

Kartika Maharani ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Cognitive Function ◽

Cognitive Assessment ◽

Verbal Learning ◽

Retest Reliability ◽

Cognitive Evaluation ◽

Test Retest Reliability

Introduction. Multiple Sclerosis (MS) can affect cognitive function that might interfere with quality of life. Processing speed and memory are the most common area of cognitive impairment. Cognitive evaluation in daily practice is often difficult to be performed since it needs neuropsychological expert and is time-consuming. Brief International Cognitive Assessment for MS (BICAMS) is valid and practical for cognitive evaluation. This study aims to validate BICAMS in Indonesian MS patients and healthy controls (HC) and to analyse the effect of cognitive impairment on quality of life. Methods. BICAMS, which composes Symbol Digits Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT-II), and Brief Visuospatial Memory Test-Revised (BVMT-R), was translated and cross-culturally adapted to Indonesian from the original BICAMS and then administered to 40 Indonesian MS patients and 66 HC matched by sex, age, and education. Test-retest reliability was performed on 16-MS patients and 42 HC. Quality of life was measured using Multiple Sclerosis Quality of Life (MSQOL-54) instrument. Results. The SDMT, CVLT-II, and BVMT-R score in MS patients were significantly lower than those in HC (effect size, r: 0.61, 0.36, and 0.47, respectively). Test-retest reliability for all tests was satisfactory with correlation coefficient for SDMT, CVLT-II, and BVMT-R in MS subjects 0.86, 0.81, and 0.83, respectively. Using 5th percentile of HC score as cut-off, 15% MS subjects had impairment in one test, 27.5% in two tests, and 40% in three tests. BICAMS was moderately correlated with EDSS but was not correlated with disease duration and relapse rate. SDMT score correlated with physical function and physical and mental role limitation. Conclusion. BICAMS is valid and reliable for assessing cognitive function of Indonesia MS patients.

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The influence of cognitive impairment on health-related quality of life in neurological disease

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2009.00439.x ◽

2010 ◽

Vol 22 (1) ◽

pp. 2-13 ◽

Cited By ~ 63

Author(s):

Alex J. Mitchell ◽

Steven Kemp ◽

Julián Benito-León ◽

Markus Reuber

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Cognitive Deficits ◽

Neurological Disorders ◽

Neurological Disease ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Mitchell AJ, Kemp S, Benito-León J, Reuber M. The influence of cognitive impairment on health-related quality of life in neurological disease.Background:Cognitive impairment is the most consistent neurological complication of acquired and degenerative brain disorders. Historically, most focus was on dementia but now has been broadened to include the important construct of mild cognitive impairment.Methods:Systematic search and review of articles linked quality of life (QoL) and cognitive complications of neurological disorders. We excluded QoL in dementia.Results:Our search identified 249 publications. Most research examined patients with brain tumours, stroke, epilepsy, head injury, Huntington's disease, motor neuron disease, multiple sclerosis and Parkinson's disease. Results suggested that the majority of patients with epilepsy, motor neuron disease, multiple sclerosis, Parkinson's disease, stroke and head injury have subtle cognitive deficits early in their disease course. These cognitive complaints are often overlooked by clinicians. In many cases, the cognitive impairment is progressive but it can also be relapsing-remitting and in some cases reversible. Despite the importance of severe cognitive impairment in the form of dementia, there is now increasing recognition of a broad spectrum of impairment, including those with subclinical or mild cognitive impairment. Even mild cognitive difficulties can have functional and psychiatric consequences–especially when they are persistent and untreated. Specific cognitive deficits such an inattention, dysexecutive function and processing speed may affect a number of quality of life (QoL) domains. For example, cognitive impairment influences return to work, interpersonal relationships and leisure activities. In addition, fear of future cognitive decline may also impact upon QoL.Conclusions:We recommend further development of simple tools to screen for cognitive impairments in each neurological condition. We also recommend that a thorough cognitive assessment should be a part of routine clinical practice in those caring for individuals with neurological disorders.

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Is the Concept of Quality of Life Relevant for Multiple Sclerosis Patients with Cognitive Impairment? Preliminary Results of a Cross-Sectional Study

PLoS ONE ◽

10.1371/journal.pone.0030627 ◽

2012 ◽

Vol 7 (1) ◽

pp. e30627 ◽

Cited By ~ 16

Author(s):

Karine Baumstarck ◽

Jean Pelletier ◽

Valérie Aghababian ◽

Françoise Reuter ◽

Irina Klemina ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Preliminary Results ◽

Multiple Sclerosis Patients

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The Multiple Sclerosis Inventory of Cognition for Adolescents (MUSICADO): A brief screening instrument to assess cognitive dysfunction, fatigue and loss of health-related quality of life in pediatric-onset multiple sclerosis

European Journal of Paediatric Neurology ◽

10.1016/j.ejpn.2019.08.006 ◽

2019 ◽

Vol 23 (6) ◽

pp. 792-800 ◽

Cited By ~ 3

Author(s):

K. Storm van's Gravesande ◽

P. Calabrese ◽

A. Blaschek ◽

K. Rostásy ◽

P. Huppke ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Dysfunction ◽

Screening Instrument ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Brief Screening ◽

Pediatric Onset

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Relation of cognitive impairment and depression to quality of life in multiple sclerosis patients

The Italian Journal of Neurological Sciences ◽

10.1007/bf00539594 ◽

1998 ◽

Vol 19 (S6) ◽

pp. S392-S398 ◽

Cited By ~ 2

Author(s):

A. Solari ◽

A. Ghezzi ◽

L. Mendozzi ◽

G. Filippini ◽

S. Cifani ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Multiple Sclerosis Patients

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Quality of life, depression and fatigue in mildly disabled patients with relapsing–remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study

Multiple Sclerosis Journal ◽

10.1177/1352458511401943 ◽

2011 ◽

Vol 17 (8) ◽

pp. 991-1001 ◽

Cited By ~ 34

Author(s):

F Patti ◽

MP Amato ◽

M Trojano ◽

S Bastianello ◽

MR Tola ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Interferon Beta ◽

Rating Scale ◽

Cognitive Status ◽

Treatment Dose ◽

Relapsing Remitting ◽

Composite Scores

Background: The precise relationships among quality of life, depression, fatigue and cognitive impairment in multiple sclerosis (MS) are complex and poorly understood. Objective: To assess the effects of subcutaneous interferon beta-1a on quality of life, depression and fatigue over 3 years in the COGIMUS study, and to examine the relationship between these outcomes and baseline cognitive status. Methods: COGIMUS was an observational 3-year trial assessing cognitive function in 459 patients with relapsing–remitting MS treated with subcutaneous interferon beta-1a. Results: In total, 331 patients completed the study (168 received interferon beta-1a, 44 µg subcutaneously three times weekly, and 163 received interferon beta-1a, 22 µg subcutaneously three times weekly). Mean MS Quality of Life-54 (MSQoL-54) composite scores did not change over time. There were no significant differences between groups in MSQoL-54 composite scores when patients were grouped by treatment dose and baseline cognitive status. Mean (standard deviation) Hamilton Depression Rating Scale score decreased from 6.8 (4.9) at baseline to 5.8 (5.9) at year 3. Mean total Fatigue Impact Scale scores were low (<30) at all time points. Conclusion: Quality of life, depression and fatigue remained largely stable over 3 years; no effects of treatment dose or baseline cognitive status were found.

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Validity and reliability of the MSQ LI in cognitively impaired patients with multiple sclerosis

Multiple Sclerosis Journal ◽

10.1191/1352458503ms971oa ◽

2003 ◽

Vol 9 (6) ◽

pp. 621-626 ◽

Cited By ~ 75

Author(s):

Ruth Ann Marrie ◽

Deborah M Miller ◽

Gordon J Chelune ◽

Jeffrey A Cohen

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Construct Validity ◽

Internal Consistency ◽

Internal Consistency Reliability ◽

Self Report ◽

Cognitively Impaired ◽

Validity And Reliability

Multiple sclerosis (MS) has important effects on quality of life but it is unknown how cognitive impairment affects the ability to assess or report this. O ur objective was to determine whether cognitive impairment negatively affects the construct validity and the reliability of the Multiple Sclerosis Q uality of Life Inventory (MSQLI). A neuropsychological test batter y and the Multiple Sclerosis Functional C omposite (MSFC) were administered to a sample of 136 patients referred for cognitive testing by their neurologists. A ge, sex, educatio n and ethnicity-adjusted T scores were calculated for each cognitive variable. C ognitive impairment was defined as any T score less than the fifth percentile. The MSQ LI was administered prior to neuropsychological testing and readministered one to four weeks later. C orrelations between the MSFC and the SF-36 were determined and compared between the cognitively impaired and unimpaired groups as the main test of construct validity. Test -retest and internal consistency reliability of each of the scales were compared for the impaired and unimpaired groups. Seventy-six (56%) patients were cognitively impaired. C onstruct validity and internal consistency reliability did not differ between the cognitively impaired and unimpaired groups. Test -retest reliability was lower for the bladder and vision scales in the impaired group, but remained acceptable for the bladder scale (r >0.7). C ognitive impairment, a common MS manifestation, does not appear to reduce the reliability or validity of the MSQ LI as a patient self-report measure of health status and quality of life.

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