Validity and reliability of the MSQ LI in cognitively impaired patients with                 multiple sclerosis

Multiple sclerosis (MS) has important effects on quality of life but it is unknown how cognitive impairment affects the ability to assess or report this. O ur objective was to determine whether cognitive impairment negatively affects the construct validity and the reliability of the Multiple Sclerosis Q uality of Life Inventory (MSQLI). A neuropsychological test batter y and the Multiple Sclerosis Functional C omposite (MSFC) were administered to a sample of 136 patients referred for cognitive testing by their neurologists. A ge, sex, educatio n and ethnicity-adjusted T scores were calculated for each cognitive variable. C ognitive impairment was defined as any T score less than the fifth percentile. The MSQ LI was administered prior to neuropsychological testing and readministered one to four weeks later. C orrelations between the MSFC and the SF-36 were determined and compared between the cognitively impaired and unimpaired groups as the main test of construct validity. Test -retest and internal consistency reliability of each of the scales were compared for the impaired and unimpaired groups. Seventy-six (56%) patients were cognitively impaired. C onstruct validity and internal consistency reliability did not differ between the cognitively impaired and unimpaired groups. Test -retest reliability was lower for the bladder and vision scales in the impaired group, but remained acceptable for the bladder scale (r >0.7). C ognitive impairment, a common MS manifestation, does not appear to reduce the reliability or validity of the MSQ LI as a patient self-report measure of health status and quality of life.

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Validation of the Multiple Sclerosis International Quality of Life questionnaire

Multiple Sclerosis Journal ◽

10.1177/1352458507080733 ◽

2007 ◽

Vol 14 (2) ◽

pp. 219-230 ◽

Cited By ~ 91

Author(s):

MC Simeoni ◽

P. Auquier ◽

O. Fernandez ◽

P. Flachenecker ◽

S. Stecchi ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Internal Consistency ◽

Discriminant Validity ◽

Short Form ◽

Life Questionnaire ◽

Validity And Reliability ◽

Sf 36 ◽

Quality Of Life Scale

This study aims to validate the Multiple Sclerosis (MS) International Quality of Life (MusiQoL) questionnaire, a multi-dimensional, self-administered questionnaire, available in 14 languages, as a disease-specific quality of life scale that can be applied internationally. A total of 1992 patients with different types and severities of MS from 15 countries were recruited. At baseline and day 21 ± 7, each patient completed the MusiQoL, a symptom checklist and the short-form (SF)-36 QoL questionnaire. Neurologists also collected socio-demographic, MS history and outcome data. The database was randomly divided into two subgroups and analysed according to different patient characteristics. For each model, psychometric properties were tested and the number of items was reduced by various statistical methods. Construct validity, internal consistency, reproducibility and external consistency were also tested. Nine dimensions, explaining 71% of the total variance, were isolated. Internal consistency and reproducibility were satisfactory for all the dimensions. External validity testing revealed that dimension scores correlated significantly with all SF-36 scores, but showed discriminant validity by gender, socio-economic and health status. Significant correlations were found between activity in daily life scores and clinical indices. These results demonstrate the validity and reliability of the MusiQoL as an international scale to evaluate QoL in patients with MS. Multiple Sclerosis 2008; 14: 219—230. http://msj.sagepub.com

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Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q) – a research tool discriminating between subjectively cognitively impaired patients and healthy controls

International Psychogeriatrics ◽

10.1017/s1041610212001846 ◽

2012 ◽

Vol 25 (3) ◽

pp. 420-430 ◽

Cited By ~ 11

Author(s):

Marie Eckerström ◽

Johanna Skoogh ◽

Sindre Rolstad ◽

Mattias Göthlin ◽

Gunnar Steineck ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Decline ◽

Internal Consistency ◽

Convergent Validity ◽

Internal Consistency Reliability ◽

Self Report ◽

Cognitively Impaired ◽

Healthy Controls ◽

Memory Functioning ◽

Α Level

ABSTRACTBackground: Subjective cognitive impairment (SCI) is a potential early marker for actual cognitive decline. The cognitive manifestation of the SCI stage is, however, largely unknown. Self-report instruments developed especially for use in the SCI population are lacking, and many SCI studies have not excluded mild cognitive impairment and dementia. We developed and tested a patient-based questionnaire on everyday cognitive function aiming to discriminate between patients with subjective, but not objective, cognitive impairment and healthy controls.Methods: Individuals experiencing cognitive impairment were interviewed to generate a pool of items. After condensing to 97 items, we tested the questionnaire in 93 SCI patients seeking care at a memory clinic (age M = 64.5 years, Mini-Mental State Examination (MMSE) M = 29.0) and 50 healthy controls (age M = 69.6 years, MMSE M = 29.3). Further item reduction was conducted to maximize that remaining items would discriminate between SCI patients and controls, using a conservative α level and requiring medium to high effect sizes. Internal consistency reliability and convergent validity was subsequently examined.Results: Forty-five items discriminated between the groups, resulting in the Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q). Internal consistency was high and correlations to a single question on memory functioning were of medium to large sizes. Most remaining items were related to the memory domain.Conclusion: The SASCI-Q discriminates between SCI patients and healthy controls and demonstrates satisfying psychometric properties. The instrument provides a research method for examining SCI and forms a foundation for future examining which SCI symptoms predict objective cognitive decline. The cognitive manifestation of the SCI stage is mostly related to experiences of memory deficits.

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Penilaian Properti Psikometrik Instrumen Kualitas Hidup (HRQol) pada Populasi Umum: Tinjauan Sistematik

JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) ◽

10.22146/jmpf.41911 ◽

2019 ◽

Vol 9 (2) ◽

Author(s):

Restu Nur Hasanah Haris ◽

Rahmat Makmur ◽

Tri Murti Andayani ◽

Susi Ari Kristina

Keyword(s):

Quality Of Life ◽

General Population ◽

Construct Validity ◽

Psychometric Properties ◽

Short Form ◽

Internal Consistency Reliability ◽

Ceiling Effect ◽

Validity And Reliability ◽

Sf 36

Quality of life (HRQoL) is a measure of a person's health in physical, spiritual, and emotional, and role functions in the society. Measurement of quality of life (HRQoL) is an important thing to understand and evaluate. Measurements are carried out not only on patients but also on the general population with the use of specific or generic instruments. The instrument used requires a psychometric properties test to ensure its validity and reliability. This article aims to conduct a systematic review of the psychometric properties of quality of life (HRQoL) instruments in the general population. Articles were collected in December 1st to 5th, 2018, from Pubmed and Google Scholar. The assessment was carried out using the checklist properties according to the cohen criteria and included the content validity, construct validity, internal consistency reliability, test-retest, ceiling effect and the level of credibility of the instruments. Among 80 articles obtained there were 24 articles that fulfilled the inclusion criteria. Short Form-36 (SF-36) instrument is the most widely used instrument in measuring the quality of life in the general population (26.6%). Some instruments have not been tested according to the criteria, while almost all instruments show a good level of validation of construct validity using convergent and discriminat validity with cronbach alpha values > 0.7. Test-retest reliability provides a good correlation. Some instruments show a ceiling effect. According to the assessment, the SF-36, SF-6D, EQ-5D, SF-12 and PedsQoL instruments are considered as established instruments. Further validation testing is needed to provide and support the measurement of subsequent quality of life (HRQoL) instruments.

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Validation of a Filipino Translation of the Children's Dermatology Life Quality Index Text Version

Acta Medica Philippina ◽

10.47895/amp.v54i3.1660 ◽

2020 ◽

Vol 54 (3) ◽

Author(s):

Paula Karina N. Gonzales-Carait ◽

Rowena F. Genuino ◽

Katrina Angela Z. Reyes ◽

Belen L. Dofitas

Keyword(s):

Quality Of Life ◽

Construct Validity ◽

Internal Consistency ◽

Skin Disease ◽

Dermatology Life Quality Index ◽

Quality Index ◽

Skin Diseases ◽

Life Quality ◽

Internal Consistency Reliability

Background. Skin diseases that are longstanding or highly symptomatic can have devastating consequences in the quality of life of children. There is a need to have a validated Filipino translation of a dermatology quality of life tool for young patients with skin diseases. Objectives. To assess the validity and reliability of the Indeks ng Kalidad ng Buhay Pang-dermatolohiya ng mga Bata (IKPaB), a Filipino translation of the Children’s Dermatology Life Quality Index (CDLQI). Methods. This cross-sectional study was conducted among children aged 4 to 16 years at a tertiary hospital outpatient department. The IKPaB was pretested and revised using focus group discussion until it was approved by the original developers for validation. Face validity was determined through cognitive debriefing interviews. Construct validity was determined by comparing IKPaB scores of participants with skin disease and without skin disease using Mann-Whitney U test. Criterion validity was determined by comparing IKPaB with a validated Filipino-translated PedsQL as the criterion, using Spearman rank correlation. Internal consistency reliability was determined using Cronbach’s coefficient. Multiple regression was used to correlate age, sex and disease duration. Results. The IKPaB was assessed to be comprehensible, clear, and culturally appropriate. Among 288 participants, it showed satisfactory construct validity (U = 8849, Z= 0.87; P = 0.89) and internal consistency reliability (α = 0.89), with a negative but weak correlation with the PedsQL® (rho= -0.300, P = 0.000). Conclusion. The IKPaB is a valid and reliable Filipino translation of CDLQI. We recommend further validation for use in clinical practice and research.

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Transcultural Adaptation and Psychometric Properties of Family Quality of Life Survey for Caregivers of People With Neurodegenerative Disease: A Study of Spanish Families Who Live in the Rural Spain-Portugal Cross-border

10.21203/rs.3.rs-302982/v1 ◽

2021 ◽

Author(s):

Marta Badia ◽

M. Begoña Orgaz ◽

Isabel Vicario-Molina ◽

Eva González-Ortega ◽

María Gómez-Vela ◽

...

Keyword(s):

Quality Of Life ◽

Internal Consistency ◽

Cultural Adaptation ◽

Convergent Validity ◽

Internal Consistency Reliability ◽

Family Quality Of Life ◽

Validity And Reliability ◽

Border Area ◽

Cross Border

Abstract Background: Neurodegenerative diseases (NDs) are one of the main causes of disability and dependence that have a great impact both on the quality of life of people with disabilities and their families. A majority of people with NDs receive career and support from the family, but there is no tool in Spain with which to measure whole-family QOL. The aim of this study was the translation, cultural adaptation, and validation of the FQOLS–Dementia into Spanish to assess FQOL among family members of individuals with NDs who live in the Spain-Portugal cross-border area.Method: The Spanish version was translated and adapted following the international guidelines for cross-cultural adaptation tests. A sample of 300 family caregivers was interviewed, applying an adapted version of the Family Quality Survey (FQOLS–Dementia). Confirmatory factor analysis was performed to validate the factor structure, and convergent validity was examined with Pearson’s correlation coefficients of the global FQOL with the domains. Internal consistency reliability was determined using Cronbach’s alpha.Results: The domain structure of the FQOLS–ND showed a good fit. In the convergent validity, it was found that the total score and the subscale domain scores were associated with the global FQOL score, except for the Values domain. Internal consistency of nine domain subscales was strong (α = .80 to .91), and excellent for the total FQOL (α = .95) and the global FQOL (α = .87).Conclusion: The FQOLS–ND presented good validity and reliability in caregiver families with individuals with ND, so its application shows its usefulness in detecting areas of improvement and intervention strategies for FQOL in the Spain-Portugal cross-border area.

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Validity and Reliability of the German Quality of Life–Alzheimer’s Disease (QoL-AD) Self-Report Scale

Journal of Alzheimer s Disease ◽

10.3233/jad-200400 ◽

2020 ◽

Vol 77 (2) ◽

pp. 581-590 ◽

Cited By ~ 1

Author(s):

Vanessa Stypa ◽

Peter Haussermann ◽

Tim Fleiner ◽

Sandra Neumann

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Construct Validity ◽

Internal Consistency ◽

Short Form ◽

Self Report ◽

Retest Reliability ◽

Test Retest Reliability

Background: The Quality of Life–Alzheimer’s Disease (QoL-AD) scale is a widely used measure of quality of life (QoL) in dementia. Although the instrument has been validated in several languages, the psychometric properties of the German self-report version have not yet been analyzed. Objective: This study examines the internal consistency, test-retest reliability, and construct validity of the German QoL-AD self-report scale. Methods: The sample included 30 patients suffering from mild to moderate Alzheimer’s disease or vascular dementia (19 females; mean age 77.3 years; mean Mini-Mental State Examination (MMSE) score 19.7 points). To determine test-retest reliability, the QoL-AD self-report scale was re-administered four to seven days apart. For construct validity analysis, the Dementia Quality of Life instrument (DQoL), Geriatric Depression Scale (GDS), MMSE, and an adapted short form of the Neuropsychiatric Inventory (NPI) were used. Results: The German QoL-AD self-report scale shows an internal consistency of α= 0.79 and a test-retest reliability of r = 0.75 (p < 0.01). Regarding construct validity, there was a significant positive correlation between the total scores of the QoL-AD and DQoL (r = 0.47, p < 0.05). The analysis revealed no significant correlations with the GDS or the adapted NPI. No association could be observed between the QoL-AD and the MMSE (r = 0.01), confirming divergent validity. Conclusion: The results indicate that the German QoL-AD self-report scale is a suitable instrument for assessing QoL in patients suffering from mild to moderate dementia, thus supporting its use in clinical practice and research.

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Transcultural adaptation and psychometric properties of Family Quality of Life Survey for caregivers of people with neurodegenerative disease: a study of Spanish families who live in the rural Spain–Portugal cross-border

Health and Quality of Life Outcomes ◽

10.1186/s12955-021-01809-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Marta Badia ◽

M. Begoña Orgaz ◽

Isabel Vicario-Molina ◽

Eva González-Ortega ◽

María Gómez-Vela ◽

...

Keyword(s):

Quality Of Life ◽

Internal Consistency ◽

Cultural Adaptation ◽

Convergent Validity ◽

Internal Consistency Reliability ◽

Family Quality Of Life ◽

Validity And Reliability ◽

Border Area ◽

Cross Border

Abstract Background Neurodegenerative diseases (NDs) are one of the main causes of disability and dependence that have a great impact both on the quality of life of people with disabilities and their families. A majority of people with NDs receive care and support from the family, but there is no tool in Spain with which to measure whole-family QOL. The aim of this study was the translation, cultural adaptation, and validation of the FQOLS–Dementia into Spanish to assess FQOL among family members of individuals with NDs who live in the Spain–Portugal cross-border area. Method The Spanish version was translated and adapted following the international guidelines for cross-cultural adaptation tests. A sample of 300 family caregivers was interviewed, applying an adapted version of the Family Quality Survey (FQOLS–Dementia). Confirmatory factor analysis was performed to validate the factor structure, and convergent validity was examined with Pearson’s correlation coefficients of the global FQOL with the domains. Internal consistency reliability was determined using Cronbach’s alpha. Results The domain structure of the FQOLS–ND showed a good fit. In the convergent validity, it was found that the total score and the subscale domain scores were associated with the global FQOL score, except for the Values domain. Internal consistency of nine domain subscales was strong (α = 0.80 to 0.91), and excellent for the total FQOL (α = 0.85) and the global FQOL (α = 0.87). Conclusion The FQOLS–ND presented good validity and reliability in caregiver families with individuals with ND, so its application shows its usefulness in detecting areas of improvement and intervention strategies for FQOL in the Spain–Portugal cross-border area.

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FV 658. Cognitive Impairment, Depression, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis: Results of the Multiple Sclerosis Inventory of Cognition in ADOlescents Study

10.1055/s-0038-1675945 ◽

2018 ◽

Author(s):

Karin Storm van's Gravesande ◽

Elke Kalbe ◽

Astrid Blaschek ◽

Pasquale Calabrese ◽

Josef Kessler ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Cognitive Impairment ◽

Pediatric Onset

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Quality of life in multiple sclerosis patients in Spain

Multiple Sclerosis Journal ◽

10.1191/1352458502ms851oa ◽

2002 ◽

Vol 8 (6) ◽

pp. 527-531 ◽

Cited By ~ 20

Author(s):

C-H Chang ◽

D Cella ◽

O Fernández ◽

G Luque ◽

P de Castro ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Well Being ◽

Cross Sectional Study ◽

Self Report ◽

Regression Analyses ◽

Cross Sectional ◽

Scale Scores ◽

Multiple Sclerosis Patients

Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach’s alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.

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