scholarly journals Pregnancy of Unknown Location: The Value of Frozen Section Analysis and Its Relation to Beta-hCG Levels and Endometrial Thickness

2018 ◽  
Vol 41 (03) ◽  
pp. 142-146
Author(s):  
Marwan Odeh ◽  
Ayat Qasoum ◽  
Rene Tendler ◽  
Mohamad Kais ◽  
Rola Khamise Farah ◽  
...  
Keyword(s):  
Predictive Value ◽  
Endometrial Thickness ◽  
Frozen Section ◽  
Frozen Sections ◽  
Frozen Section Examination ◽  
Section Technique ◽  
Products Of Conception ◽  
Frozen Section Analysis ◽  
Β Hcg ◽  
Section Analysis

Objective Frozen section examination is a rapid method for identifying products of conception in endometrial curetting, yet its accuracy is inconclusive. The purposes of this study is to determine the accuracy of frozen section analysis of endometrial curetting in pregnancies of unknown location, and to verify the relation of β-human chorionic gonadotrophin (hCG) level and endometrial thickness to the assessed accuracy. Methods We reviewed data from January 2009 to December 2014 of diagnostic curettages from women with suspected ectopic pregnancies sent for frozen section examination at a medical center. A frozen section diagnosis was considered accurate if it concurred with the final pathologic diagnosis. Results Of 106 frozen section studies, the diagnosis was accurate in 94 (88.7%). Of 79 specimens interpreted as negative on frozen sections (no products of conception noted), 9 (11.4%) were positive on final pathologic review. Three of the 27 (11.1%) specimens interpreted as positive by a frozen section failed to demonstrate products of conception on a final pathologic section. The sensitivity of frozen sections in the diagnosis of ectopic pregnancy was 72.7%, specificity 95.9%, positive predictive value 88.9%, negative predictive value 88.6%, and accuracy 88.6%. A statically significant correlation was found between β-hCG level and high accuracy of the frozen section technique (p < 0.001). No correlation was found between endometrial thickness and the accuracy of the frozen section technique. Conclusion The accuracy of frozen section examination was high and was found to correlate with β-hCG level, but not with endometrial thickness.

Acuracy of Frozen Section Diagnosis of Parotid Lesions

1979 ◽  
Vol 88 (4) ◽  
pp. 573-576 ◽  
Author(s):  
Robert H. Miller ◽  
Thomas C. Calcaterra ◽  
Donald E. Paglia
Keyword(s):  
Frozen Section ◽  
Active Participation ◽  
Frozen Sections ◽  
Benign Lesions ◽  
Section Technique ◽  
Frozen Section Analysis ◽  
Frozen Section Diagnosis ◽  
Malignant Lesions ◽  
Section Analysis

The accuracy of frozen section diagnosis was analyzed in a review of 132 parotid lesions. Of 107 benign lesions, 93% were correctly diagnosed on frozen section analysis, but of 25 malignant lesions, only 9 frozen sections were accurately interpreted. This study points out the difficulty encountered in using the frozen section technique when dealing with malignant parotid lesions and the importance of the surgeon's active participation in the analysis.

“True” versus “apparent” stage I epithelial ovarian cancer: value of frozen section analysis

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 41-46 ◽  
Author(s):  
R. Naik ◽  
P. Cross ◽  
A. Lopes ◽  
K. Godfrey ◽  
M. H. Hatem
Keyword(s):  
Ovarian Cancer ◽  
Predictive Value ◽  
Frozen Section ◽  
Paraffin Section ◽  
Test Results ◽  
Borderline Tumors ◽  
Frozen Section Analysis ◽  
Clinical Benefits ◽  
Section Result ◽  
Section Analysis

The aim of this prospective study was to determine the clinical benefits of introducing peroperative frozen section analysis into the surgical management policy of women referred with an adnexal mass suspicious of ovarian cancer. All women surgically managed at the Northern Gynaecological Oncology Centre, Gateshead, UK, between July 1, 2002, and June 30, 2003, where frozen section analysis had been utilized were included for analysis. Correlation was determined between cases surgically staged following the frozen section result and the clinical need for staging based on the pathologic diagnosis from the paraffin section. During the 12-month period, 130 women underwent frozen section analysis. Paraffin section diagnoses included 74 benign tumors, 11 borderline tumors, 34 primary epithelial cancers, 5 nonepithelial cancers, and 6 metastatic tumors. All primary epithelial ovarian cancers were correctly identified as requiring a staging procedure based on the frozen section result. Four of seventy-four cases reported as benign on frozen section analysis were underdiagnosed; two were later diagnosed on paraffin section as borderline tumors and a further two as malignant (one low-grade adenosarcoma and one primary peritoneal cancer). Of the 130 cases, 55 (42.3%) underwent a staging procedure based on the frozen section result. The value of frozen section analysis in determining the need for the performance of a staging procedure had the following statistical test results: sensitivity = 92%, specificity = 88%, positive predictive value = 82%, and negative predictive value = 95%. Excluding the borderline tumors, metastatic tumors, and primary peritoneal tumor where staging did not impact subsequent clinical management, the statistical test results for frozen section analysis in determining the need for a staging procedure were sensitivity = 97%, specificity = 95%, positive predictive value = 90%, and negative predictive value = 99%. The clinical benefits of introducing frozen section analysis in the surgical staging policy of women with an adnexal mass suspicious of ovarian malignancy included avoidance of a surgical staging procedure in 95% of cases identified on paraffin section analysis to be benign. This benefit was without compromising the avoidance of chemotherapy in true stage I epithelial ovarian cancer cases. Additional benefits included the confirmation of malignancy where extraovarian lesions were suggestive but not indicative of malignant disease, and the intraoperative identification of metastatic disease of nonovarian origin.

Intraoperative Frozen Section Analysis for the Excision of Nonmelanoma Skin Cancer: A Single-Center Experience

2019 ◽  
Vol 85 (12) ◽  
pp. 1397-1401
Author(s):  
Tylert Bilden ◽  
Katherine C. Benedict ◽  
Patrick W. Lamb ◽  
Jaron Mcmullin
Keyword(s):  
Skin Cancer ◽  
Predictive Value ◽  
Frozen Section ◽  
False Negative ◽  
Surgical Excision ◽  
Nonmelanoma Skin Cancer ◽  
Intraoperative Frozen Section ◽  
Frozen Section Analysis ◽  
Delayed Reconstruction ◽  
Section Analysis

Surgical resection of nonmelanoma skin cancer (NMSC) may be performed via Mohs micrographic surgery (MMS) or standard surgical excision with complete margin analysis. Whereas MMS may necessitate delayed reconstruction surgery, intraoperative frozen section analysis (IFSA) may be used to ensure clear surgical margins before proceeding with reconstruction. To achieve curative resection while optimizing aesthetic outcomes, surgeons may use surgical excision guided by IFSA to forego extensive or delayed reconstruction. Patients undergoing wide local excision for NMSC using IFSA from October 2008 to November 2016 were evaluated. Analysis included IFSA versus permanent section outcomes, the number of required excisions, and the recurrence rate. Our analysis contained 145 patients involving 162 lesions. IFSA demonstrated that 73.4 per cent of margins were negative after one excision and 26.5 per cent were re-excised until achieving negative margins. Analysis revealed one false-positive case (0.62%) and four false-negative cases (2.47%). Nine patients had local recurrence (5.56%). Frozen section sensitivity was 88.99 per cent and specificity 99.20 per cent. The positive predictive value was 96.97 per cent, and negative predictive value was 96.90 per cent. Mean follow-up time was 39 months. Both resection and recurrence data of excised NMSC lesions at our institution suggest that surgical excision using IFSA is a safe and effective alternative to MMS.

scholarly journals Role of frozen section analysis of testicular/paratesticular fibrous pseudotumours: a five-case experience

2013 ◽  
Vol 5 (4) ◽  
pp. 47
Author(s):  
Jennifer Gordetsky ◽  
Jennifer Findeis-Hosey ◽  
Erdal Erturk ◽  
Edward M. Messing ◽  
Jorge L. Yao ◽  
...  
Keyword(s):  
Frozen Section ◽  
Frozen Sections ◽  
Frozen Section Analysis ◽  
Intraoperative Management ◽  
Radical Orchiectomy ◽  
Section Analysis

Background: Fibrous pseudotumours of the testicular and paratesticulartissues are fibroinflammatory reactive lesions that canclinically mimic neoplasms. Very little is known about the role offrozen section analysis (FSA) for these lesions in terms of intraoperativesurgical management.Methods: We recently experienced 5 patients with testicular/paratesticularfibrous pseudotumours in whom frozen sections wereused to demonstrate its non-neoplastic nature prior to the decisionfor radical surgery.Results: In 2 cases, FSA resulted in testicular-sparing surgery. Incontrast, the remaining 3 cases ultimately underwent radical orchiectomy,due to questionable viability of the testicle involved byinflammatory/infiltrative lesions and in 1 case a slight possibilityof lymphoproliferative malignancy.Conclusion: Urologists should be aware of this entity and its grossfeatures, such as firm masses and diffuse fibrous proliferation encasingthe testicle to help determine intraoperative management. Inselect cases, intraoperative FSA is helpful in obviating radicalorchiectomy.

Accuracy of frozen-section analysis in the diagnosis of ovarian tumors: a systematic quantitative review

2005 ◽  
Vol 15 (2) ◽  
pp. 192-202 ◽  
Author(s):  
L. R. Medeiros ◽  
D. D. Rosa ◽  
M. I. Edelweiss ◽  
A. T. Stein ◽  
M. C. Bozzetti ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Ovarian Tumor ◽  
Frozen Section ◽  
Ovarian Tumors ◽  
Frozen Sections ◽  
Borderline Tumors ◽  
Frozen Section Analysis ◽  
Accuracy Rates ◽  
Section Result ◽  
Section Analysis

A quantitative systematic review was performed to estimate the diagnostic accuracy of frozen sections in ovarian tumors. Studies that compared frozen sections and paraffin sections within subjects for diagnosis of ovarian tumors were included. Fourteen primary studies were analyzed, which included 3 659 women. For benign ovarian vs borderline/malignant tumor cases, the occurrence of a positive frozen-section result for benignity (pooled likelihood ratio [LR], 8.7; 95% confidence interval [CI], 7.3–10.4) and posttest probability for benign diagnosis was 95% (95% CI, 94–96%). A positive frozen-section result for malignant vs benign diagnosis (pooled LR, 303; 95% CI, 101–605) increased the probability of ovarian cancer to 98% (95% CI, 97–99%). In borderline vs benign ovarian tumor cases, a positive frozen-section result (pooled LR, 69; 95% CI, 45–106) increased the probability of borderline tumors to 79% (95% CI, 71–85%). In borderline vs malignant ovarian tumor cases, a positive frozen-section result (pooled LR, 18; 95% CI, 13–26) increased the probability of borderline tumors to 51% (95% CI, 42–60%). We conclude that diagnostic accuracy rates for frozen-section analysis is high for malignant and benign ovarian tumors, but the accuracy rates in borderline tumors remain relatively low.

scholarly journals Accuracy of Intra-Operative Frozen Section Analysis of Ovarian Tumours

2009 ◽  
Vol 37 (4) ◽  
pp. 1173-1178 ◽  
Author(s):  
B Gorišek ◽  
M Rebolj Stare ◽  
I Krajnc
Keyword(s):  
Preoperative Diagnosis ◽  
Frozen Section ◽  
False Negative ◽  
Frozen Sections ◽  
Frozen Section Analysis ◽  
Clinical Centre ◽  
Ovarian Tumours ◽  
The University ◽  
Positive Results ◽  
Section Analysis

During operative treatment for ovarian tumours assistance is frequently required to make decisions regarding malignancy status and the extent of the ensuing procedure. Intra-operative frozen section analysis may be useful, provided there is adequate acquaintance with the correlation between using frozen sections and permanent histopathological sections for diagnosis at the institution where the operation is being undertaken. This retrospective study aimed to determine this correlation. Findings from 131 intraoperative frozen sections were compared with the subsequent diagnosis from permanent histopathological sections for women with benign, borderline and malignant ovarian tumours at the Maribor Teaching Hospital (now the University Clinical Centre Maribor) between 1 January 1993 and 31 December 2001. Frozen-section findings corresponded to histopathological findings in 84.7% of cases, with 15.3% false-negative and no false-positive results. For benign, borderline and malignant ovarian tumours, sensitivity was 100.0%, 76.1% and 89.0%, respectively, and specificity was 90.6%, 90.6% and 100.0%, respectively. The majority of errors occurred in diagnosing mucinous borderline tumours. Precise preoperative diagnosis is extremely important in the treatment of ovarian tumours.

Predictive value of frozen-section analysis in the histological assessment of steatosis before liver transplantation

2009 ◽  
Vol 15 (12) ◽  
pp. 1821-1825 ◽  
Author(s):  
Michelangelo Fiorentino ◽  
Francesco Vasuri ◽  
Matteo Ravaioli ◽  
Lorenza Ridolfi ◽  
Walter Franco Grigioni ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Predictive Value ◽  
Frozen Section ◽  
Histological Assessment ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Accuracy of Intraoperative Frozen Section in Detection of Acute Invasive Fungal Rhinosinusitis

2020 ◽  
Author(s):  
Rahaf Alkhateb ◽  
Preethi Dileep Menon ◽  
Hamza Tariq ◽  
Sarah Hackman ◽  
Alia Nazarullah ◽  
...  
Keyword(s):  
Predictive Value ◽  
Frozen Section ◽  
Fungal Culture ◽  
Fungal Sinusitis ◽  
Fungal Rhinosinusitis ◽  
Acute Invasive Fungal Rhinosinusitis ◽  
Frozen Section Analysis ◽  
Early Surgical Intervention ◽  
Invasive Fungal Rhinosinusitis ◽  
Section Analysis

Context.— Acute invasive fungal rhinosinusitis (AIFRS) is an aggressive form of fungal sinusitis, which remains a significant cause of morbidity and mortality. Early diagnosis and intervention are keys to improving patient outcomes. Intraoperative consultation has shown promise in facilitating early surgical intervention, but the accuracy of frozen section has not been clarified in this setting. Objectives.— To assess the accuracy of frozen-section diagnosis in patients with clinically suspected AIFRS. Design.— All cases of clinically suspected AIFRS during a 10-year period (2009–2019) were retrospectively reviewed. The frozen-section results were compared with the final permanent sections as well as the tissue fungal culture results, following which the accuracy of frozen section was determined. Results.— Forty-eight patients with 133 frozen-section evaluations for AIFRS were included in the study. Thirty of 48 patients and 61 of 133 specimens were positive for AIFRS on final pathology. Of 30 positive patients, 27 (90%) had at least 1 specimen diagnosed as positive during intraoperative consultation, among the 61 positive specimens, 54 (88.5%) were diagnosed as positive during intraoperative consultation. Of 72 negative specimens, all were interpreted as negative on frozen section. Thus, frozen sections had a sensitivity of 88.5% (95% CI, 0.78–0.97), specificity of 100% (95% CI, 0.94–1), positive predictive value of 100% (95% CI, 0.92–1), and negative predictive value of 90.6% (95% CI, 0.82–0.97). Conclusions.— This study represents the largest series assessing the diagnostic accuracy of frozen section analysis in AIFRS. These findings are useful in frozen section–informed intraoperative decision making.

RESEARCH ON VALUE OF INTRAOPERATIVE FROZEN SECTION EXAMINATION OF THE COMMON TUMORS AT HUE UNIVERSITY HOSPITAL

2011 ◽  
pp. 67-73
Author(s):  
Cong Thuan Dang ◽  
Thi Thu Thao Le
Keyword(s):  
Sensitivity And Specificity ◽  
Frozen Section ◽  
Analysis Data ◽  
Poor Quality ◽  
University Hospital ◽  
Frozen Sections ◽  
Intraoperative Frozen Section ◽  
Frozen Section Examination ◽  
Incorrect Diagnosis ◽  
The Common

Background: To evaluate the accuracy and the pitfalls of frozen section examination in diagnosis the common tumors at Hue University Hospital. Materials and method: A retrospective analysis data of 99 consecutive patients from 2007 to 2009 were evaluated and analyzed the major pitfalls. In our 99 patients, 100% cases we compared histological diagnosis on frozen sections with those on paraffin sections. Results: The majority of frozen section examinations were the thyroid lesions 37.4%, breast lesions 25.2%, lymph nodes 16.1%, ovary 9.1% and less common in other diseases (12.1%). The accuracy, sensitivity and specificity of the intraoperative frozen section examination were 93.9%, 89.1% and 98.1% respectively. The main factors causing incorrect diagnosis in frozen section are: Misinterpretation, poor quality of frozen sections, improper sampling in sectioning and difficult to result interpretation. Conclusion: The frozen section analysis of suspect lesions displays good sensitivity and specificity characteristics.

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