Reducing the Side Effects of Thrombolytic Agent by Regulating its Release Rate from Microcapsules

In geriatric patients the use ofstreptokinase or urokinase is oftenlimited by contraindications, particularly hypertension. As it has been demonstrated by different authors, the polyanionic compound pentosanpolysulphate SP 54 induced an activation of both intrinsic and extrinsic pathway of fibrinolysis and produced a mild decrease of blood prssure. From thise characteristics pentosan polysulphate SP54 should be anideal thrombolytic agent in geriatric patients. To clarify this, an open prospective studie was performed. 24 patient(16 females, 8 males ) age 65 -78 years , suffering from thromboembolicprocesses ( 8 deep vein thrombosis(DVT), 16 thrombosis of reti na vessels ( TRV) were included. Pentosan polysulphat SP 54 (BENE-PHARMA Munchen, F.R.G.) was administred byintravenous infusion 300 mg daily over a period of 10 days. Venographyor ophthalmoskopie were repeated atday 11.Results:Side effects: Bleeding 0 ; thrombocytopenia 2It is concluded from these results, that pentosan polysulphate SP54is an useful thrombolytic agent in particular in geriatric patients suffering from hypertension.

Download Full-text

Silica-Alginate Beads for Intestinal Ketoprofen Delivery

Revista de Chimie ◽

10.37358/rc.18.12.6761 ◽

2019 ◽

Vol 69 (12) ◽

pp. 3416-3422

Author(s):

Marilena Petrescu ◽

Raul Augustin Mitran ◽

Cristian Matei ◽

Marius Radulescu ◽

Daniela Berger

Keyword(s):

Side Effects ◽

Drug Release ◽

Mesoporous Silica ◽

Release Rate ◽

Release Kinetics ◽

Alginate Beads ◽

Drug Release Rate ◽

Silica Materials ◽

Mesocellular Foam Silica ◽

Mcm 41

Herein, studies on ketoprofen delivery systems based on silica-alginate beads developed for the drug intestinal release for reducing its side effects were reported. The influence of surface properties, pore size and geometry of mesoporous silica carriers on the ketoprofen release kinetics was studied by using pristine and 3-aminopropyl functionalized MCM 41 (Mobile Composition of Matter) and MCF (mesocellular foam silica) materials. The ketoprofen loaded mesoporous silica coated with alginate is a pH-triggered system able to slow down the drug release rate in the targeted environment.

Download Full-text

Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

Download Full-text

Effects of cisplatin treatment on the rat neurohypophysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100142256 ◽

1986 ◽

Vol 44 ◽

pp. 122-123

Author(s):

J.M. Fadool ◽

P.J. Boyer ◽

S.K. Aggarwal

Keyword(s):

Side Effects ◽

Urine Output ◽

Morphological Changes ◽

Limiting Factor ◽

Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

Download Full-text

Severe Drooling and Treatment With Botulinum Toxin

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd21.1.15 ◽

2012 ◽

Vol 21 (1) ◽

pp. 15-21

Author(s):

Merete Bakke ◽

Allan Bardow ◽

Eigild Møller

Keyword(s):

Botulinum Toxin ◽

Side Effects ◽

Health Risk ◽

Flow Rate ◽

Clinical Evidence ◽

Acetylcholine Release ◽

Psychosocial Problems ◽

Rate Reduction ◽

Local Inhibition ◽

Surgical Treatments

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.

Download Full-text