A Study of the Asphctic Newborn Related to Hypercoagulability by Determination of Soluble Fibrin Monomer Complex (SFMC) and Plasmin Inhibitor
Gordblood samples from 80 healthy newborns and 19 asphyctic newborns were examined. SFMG and fibrinogen were precipitated from plasma with β-alanine.Agarose gel filtration of redissolved precipitate resulted in separation of SFMC and fibrinogen. Other parameters such as TEG, Prothrombin time (PT), Partial thromboplastin time (PTT), and Plasmin-inhibitors (α2-macrogloblin, α1-antitrypsin, antithrombin III)were also determined. (Results)(1) The percent amount of SFMC of total fibrinogen content in asphyctic newborn increased 4.73 ± 1.55%, while the remaining normal infants showed only 3.17 ± 0.55% (P < 0.05)(2) In neither PT nor PTT can a significant difference be seen, although asphyctic newborn showed the tendency of hypercoagulability in TEG.(3) α1-antitrypsin (92.8 ± 21.5)and antithrombin III(8.4 ± 2.3) levels were much lower in the group with asphyxia.These results indicate that a low level of Plasmin-inhibitors act synergestically with a high activator value.The low antithrombin III level in particular could be one of the reason for the development Hypercoagulability and DIC in asphyctic newborn infants.