scholarly journals Peri-Implant Diseases

2021 ◽  
Author(s):  
Dipanjan Das ◽  
Nina Shenoy
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Inflammatory Lesion ◽  
Bacterial Biofilm ◽  
Term Survival ◽  
Diagnostic Aspects ◽  
Inflammatory Conditions ◽  
Dental Prostheses ◽  
Implant Treatment

AbstractOsseointegrated dental implants have become an increasingly popular modality of treatment for the replacement of absent or lost teeth because of its high rates of long-term survival when used to support various types of dental prostheses. However, complications and implant failure can still occur and are considered by many clinicians as a major obstacle for implant treatment. Biological complications mainly refer to inflammatory conditions of the soft tissues and bone surrounding implants and their restorative components, which are induced by the accumulation of bacterial biofilm. Two clinical varieties may be distinguished: peri-implant mucositis and peri-implantitis. Peri-implant mucositis is a reversible, plaque-induced inflammatory lesion confined to the peri-implant soft tissue unit, whereas peri-implantitis is an extension of peri-implant mucositis to involve the bone supporting the implant. Diagnosing and managing these biological complications is of utmost importance for the implant surgeon and dental practitioner. This review encompasses the etiology, diagnostic aspects, prevention, and management of biological complications.

scholarly journals Injectable prevascularized mature adipose tissues (iPAT) to achieve long-term survival in soft tissues regeneration

2020 ◽  
Author(s):  
Fiona Louis ◽  
Yoshihiro Sowa ◽  
Shinji Irie ◽  
Shiro Kitano ◽  
Osam Mazda ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Umbilical Vein ◽  
Soft Tissue Reconstruction ◽  
Term Survival ◽  
Adipose Tissues ◽  
Soft Tissue Regeneration ◽  
Tissue Reconstruction ◽  
Umbilical Vein Endothelial Cells

AbstractSoft tissue regeneration remains a challenge in reconstructive surgery. Current autologous fat implantations lead to high fat absorption ratios, while artificial implants can be associated with lymphoma occurrence. To overcome these limitations, our aim was to reproduce adipose tissue vasculature structure before implantation. Here, we developed injectable prevascularized adipose tissues (iPAT), using physiological collagen microfibers (CMF) mixed with human mature adipocytes, adipose-derived stem cells (ADSC) and human umbilical vein endothelial cells (HUVEC). Following murine subcutaneous implantation, higher cell survival (84±6% viability) and volume maintenance were shown after 3 months for the iPAT (up to twice heavier than the non-prevascularized balls). This higher survival can be explained by the greater amount of blood vessels (up to 1.6 folds increase), with balanced host anastomosis (51±1% of human/mouse lumens), also involving infiltration by the lymphatic and neural vasculature networks. These iPAT tissues allowed non-invasive soft tissue reconstruction for long-term outcomes, and the ability to cryopreserve them with maintained viability and functionality also enables a later reinjection usually required before reaching the final patient desired graft volume.

Esthetic And Functional Integration Of Soft Tissue Around Dental Implants: Thickness, Width, Stability.

2021 ◽  
Author(s):  
Aleksandr Lysov ◽  
Andre Saadoun
Keyword(s):  
Soft Tissue ◽  
Functional Integration ◽  
Daily Practice ◽  
Clinical Approach ◽  
Soft Tissue Management ◽  
Mucosal Thickness ◽  
Biological Protection ◽  
The Stability ◽  
Implant Treatment

The long-term Functional success of the implant treatment depends on the stability of the crestal bone tissue around the implant platform. The Esthetic result is achieved by an adequate soft tissue in the peri-implant zone. Furthermore, the soft tissue creates the buffer area that ensures the mechanical and biological protection of the underlying bone. Therefore, it is necessary to maintain for a long term, not only the implant osseointegration but also the integration of the soft tissue around the Sub and Supra-structure of the restoration. In order to create the protective soft tissue area, it is necessary to ensure three criteria. This treatment approach will be defined as the TWS – Soft Tissue Management : T for Thickness , W for Width, and S for Stability . The purpose of this article is to present with clinical cases, the detailed description of each criteria. There are many ways to achieve the two first criteria and they are well described in the literature. Achieving the third criteria of the Stability become possible only in the last years since the development of the digital technology and its implementation into the dental practice. A one time abutment and the creation of peri- implant mucosal thickness with an optimal amount of the attached keratinized gingiva above and around the implant platform, for muco-gingival integration of the system, are therefore a prerequisite for functional and esthetic result. The article presents the possibility for the clinicians to use in their daily practice this new clinical approach of TWS - Soft Tissue Management.

Extended ray resection for sarcoma of the hand: long-term survival and functional results

2019 ◽  
Vol 45 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Farhad Farzaliyev ◽  
Hans-Ulrich Steinau ◽  
Halil-Ibrahim Karadag ◽  
Alexander Touma ◽  
Lars Erik Podleska
Keyword(s):  
Soft Tissue ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Functional Results ◽  
Contralateral Side ◽  
Level Of Evidence ◽  
Term Survival ◽  
Kaplan Meier

In this retrospective study, we analysed the long-term oncological and functional results after extended ray resection for sarcoma of the hand. Recurrence-free and overall survivals were calculated using the Kaplan–Meier method. The function of the operated hand was assessed with the Michigan Hand Questionnaire and compared with the contralateral side. Extended ray resection was performed in 25 out of 168 consecutive patients with soft-tissue and bony sarcomas of the hand. The overall 5- and 10-year, disease-specific survival rates were 86% and 81%, respectively. Local recurrences were observed in two patients. The Michigan Hand Questionnaire score for the affected hand at follow-up in nine patients was 82 points versus 95 for the healthy contralateral hands. We conclude that extended ray resection of osseous sarcomas breaking through the bone into the soft tissue or for soft tissue sarcomas invading bone is a preferable alternative to hand ablation when excision can be achieved with tumour-free margins. Level of evidence: III

scholarly journals Gingival Response to Dental Implant: Comparison Study on the Effects of New Nanopored Laser-Treated vs. Traditional Healing Abutments

2020 ◽  
Vol 21 (17) ◽  
pp. 6056
Author(s):  
Barbara Ghinassi ◽  
Angela Di Baldassarre ◽  
Gianmaria D’Addazio ◽  
Tonino Traini ◽  
Mauro Andrisani ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Surface Topography ◽  
Soft Tissues ◽  
Point Of View ◽  
Lower Grade ◽  
Machined Surface ◽  
Tissue Microenvironment ◽  
Second Stage ◽  
The One

The health of peri-implant soft tissues is important for the long-term success rate of dental implants and the surface topography is pivotal in influencing it. Thus, the aim of this study was to evaluate, in human patients, the inflammatory mucosal microenvironment in the tissue surrounding a new, nanoscale, laser-treated healing abutment characterized by engineered nanopores versus a standard machined-surface. Analyses of anti- and pro-inflammatory markers, cytokeratins, desmosomal proteins and scanning electron microscopy were performed in 30 soft-tissue biopsies retrieved during second-stage surgery. The results demonstrate that the soft tissue surrounding the laser-treated surface was characterized by a lower grade of inflammation than the one facing the machined-surface, which, in turn, showed a disrupted epithelium and altered desmosomes. Moreover, higher adhesion of the epithelial cells on the laser-treated surface was detected compared to the machined one. In conclusion, the laser-treated surface topography seems to play an important role not only in cell adhesion, but also on the inflammatory makers’ expression of the soft tissue microenvironment. Thus, from a clinical point of view, the use of this kind of topography may be of crucial importance not only on healing abutments but also on prosthetic ones.

A Profile of 44 Long Term Survivors (>10yrs) with AL Amyloidosis.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4765-4765
Author(s):  
Ashutosh D. Wechalekar ◽  
Helen J. Lachmann ◽  
Julian D. Gillmore ◽  
Philip N. Hawkins
Keyword(s):  
Soft Tissues ◽  
Performance Status ◽  
Organ Involvement ◽  
Whole Body ◽  
Al Amyloidosis ◽  
Term Survival ◽  
Long Term Outcome ◽  
Significant Difference ◽  
Amyloid Load

Abstract AL amyloidosis has a poor outcome. Survival of only about one year was frequently reported in studies performed in the 1990s, and the diagnosis of AL amyloidosis continues to be widely regarded as incompatible with long term survival. We report here the features of patients with AL amyloidosis followed up at the UK Amyloidosis centre (NAC) for more than 10 years, who encouragingly represented more than 10% of all cases. All patients with AL amyloidosis who first attended the NAC between 1979–1997 and subsequently survived for more than 10 years were included in this study. AL type amyloidosis was confirmed in all patients histologically with genetic studies to robustly exclude hereditary amyloidosis as indicated. Organ involvement and responses were defined as per the international consensus criteria (Gertz et al 2005). I123 serum amyloid P (SAP) scintigraphy was used to identify additional organ involvement and monitor amyloid load. 361 patients with AL amyloidosis were assessed at the NAC before 1st August 1997, with a median survival of 2.4 yrs. 132 (20%) patients survived >5 yrs, and 44 (12%) patients survived >10 years with 2 patients living ≥ 16 yrs and 7 for ≥ 14 yrs. Three patients died at 10.2, 11 and 13 years due to unrelated causes with no deaths due to progressive amyloidosis. Among the 44 ten year survivors, at presentation, median age was 51 yrs (29–70), median creatinine 86μmol/L (47–400), 24 hour proteinuria 2g (<0.1g–50g), bilirubin 8μmol/L (2–130), alkaline phosphatase 82.5 units/L (41–2645), and median NT-ProBNP 19 pMol/L (1–2158). Median ECOG performance status was 1 (0–2). Organ involvement (consensus criteria) was: renal 31 (70%); liver 6 (14%); cardiac 8 (18%); autonomic neuropathy 1(2%); peripheral neuropathy - none; gastrointestinal 2(4%) and lymph nodes or other soft tissues 4 (9%). SAP scintigraphy showed renal amyloid deposits in 30 (68%), liver 11(25%), adrenals 3(7%) and bone infiltration 7 (16%). 35 (79%) had one organ involved, 8 (18%) had 2 organs and 1 (3%) patient had three organs involved by consensus criteria; SAP scintigraphy detected additional organ involvement in 12 cases (27%). The whole body amyloid load on SAP scintigraphy was small in 25(57%), moderate 2 (4%) and large 9 (21%). Median plasma cell infiltrate in the marrow was 5% (1–65). Treatment received comprised an alkylator based regimen in 11(26%), VAD chemotherapy in 14 (32%), and stem cell transplantation (SCT) in 18 (42%). 29 (67%) patients had a complete clonal response, 13 (30%) had a partial response and 1 (2%) had no response. 25(57%) had evidence of organ improvement by conventional criteria and in 26 (59%) SAP scintigraphy showed regression of amyloid. The median time to next treatment (progression free survival - PFS) has not been reached at 10 yrs. There was no significant difference in the PFS between patients treated chemotherapy or SCT, or among the complete or partial responders. 13 patients (30%) developed end stage renal disease (ESRD) a median 5.8 yrs after diagnosis and this was not significantly more frequent among partial responders compared with complete hematologic responders. Substantial improvements in diagnosis, monitoring and treatment of AL amyloidosis have occured since 1997. It is all the more encouraging that we are able to report here that 12% of patients diagnosed before this time survived for more than 10 years and patients with AL amyloidosis diagnosed more recently are likely to have even better prospect of good long term outcome in cases who achieve good and sustained clonal responses to therapy.

scholarly journals Actual Long-Term Survival After Resection of Stage III Soft Tissue Sarcoma

2020 ◽  
Author(s):  
Do Weon Lee ◽  
Han-Soo Kim ◽  
Ilkyu Han
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Tumor Size ◽  
Poor Prognosis ◽  
Histological Grade ◽  
Stage Iii ◽  
Term Survival ◽  
Long Term Survival ◽  
Long Term Survivors

Abstract Background: Actuarial survival based on the Kaplan–Meier method can overestimate actual long-term survival, especially among those with factors of poor prognosis. Patients with American Joint Committee on Cancer stage III soft tissue sarcoma (STS) represent a subset with a high risk of STS-specific mortality. Therefore, we aimed to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III STS.Methods: We retrospectively reviewed 116 patients who underwent surgical resection for stage III STS with curative intent between March 2000 and December 2013. Long-term survivors (n = 61), defined as those who survived beyond 5 years, were compared with short-term survivors (n = 36), who died of STS within 5 years.Results: Multivariate logistic regression analyses showed that a tumor size <10 cm [odds ratio (OR) 3.95, p = 0.047], histological grade of 2 (OR 8.12, p = 0.004), and American Society of Anesthesiologists (ASA) score of 1 (OR 11.25, p = 0.001) were independently associated with actual 5-year survival. However, 66% of the long-term survivors exhibited factors of poor prognosis: 36% had a tumor size >10 cm and 48% had a histological grade of 3. Leiomyosarcoma (3 of 10) was negatively associated with actual long-term survival.Conclusions: Actual 5-year survival after resection of stage III STS was associated with tumor size, histological grade, and ASA score. However, majority of the actual 5-year survivors exhibit factors of poor prognosis, suggesting that resection should be offered for a chance of long-term survival in these patients.

scholarly journals Immediate results of electrochemotherapy for malignant tumors of the skin and soft tissues, cutaneous and subcutaneous metastases of melanoma

2020 ◽  
Vol 56 (2) ◽  
pp. 31-34
Author(s):  
D. A. Tuleuova ◽  
G. A. Serikbaev ◽  
A. K. Kurmanaliev ◽  
J. U. Pysanova ◽  
Sh. P. Najibulo ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Soft Tissue ◽  
Malignant Tumors ◽  
Cell Membrane Permeability ◽  
Long Term Results ◽  
Temporary Increase ◽  
Surgical Removal ◽  
Term Survival ◽  
Subcutaneous Metastases

Relevance: Surgical removal of locally advanced forms of skin cancer and multiple cutaneous and subcutaneous metastases of melanoma does not always provide satisfactory aesthetic, functional, and long-term results. The treatment outcomes depend on the size, shape, location, and some other characteristics of the tumor. The relapse rate after surgical removal of locally advanced skin cancer is 12.5-34%, and the long-term survival of patients with cutaneous and subcutaneous metastases of melanoma does not exceed 30%. Cutaneous and subcutaneous metastases of melanoma and some superficial tumors are usually initially inoperable. Their complications such as bleeding, infection, pain, and pitting cause serious clinical problems and often require local therapy even at the 4th stage of the disease. Electrochemotherapy (ECT) is one of the modern treatment methods for skin cancer, soft tissue sarcoma, and metastatic melanoma. ECT is a treatment of choice in the presence of contraindications to surgical and radiation therapy. ECT combines the physical properties of current-induced electroporation with the chemical properties of chemotherapeutic drugs. In this method, an electric current affecting the tissue causes a temporary increase in cell membrane permeability, thereby providing free access to the cell of large molecules, including cytostatics, which are not initially transferred to the cytosol. This significantly increases the potential toxicity of cytostatics. The purpose of this study was to demonstrate the immediate results of ECT in patients with malignant tumors of the skin, soft tissue, cutaneous, and subcutaneous melanoma metastases. Results: Since 2017, 27 patients were treated by ECT at the Centre for bone and soft tissue tumors and melanomas of Kazakh Institute of Oncology and Radiology (Almaty, Kazakhstan). After two months, 67% of patients had a complete response (CR), 26% – a partial response (PR), and 7% had progression of the tumor. Side effects included local edema (n=13, 40%) which independently disappeared within several days to 2 weeks, local pains (12%) which disappeared within six months after treatment in 3% and within a month in 11% of patients, and hyperthermia in the early postoperative period in 6% of patients which was stopped within 10-15 min after the procedure

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