scholarly journals Antimicrobial Constituents from Leaves of Dolichandrone spathacea and Their Relevance to Traditional Use

2018 ◽  
Vol 5 (01) ◽  
pp. e14-e23 ◽  
Author(s):  
Phuc-Dam Nguyen ◽  
Amin Abedini ◽  
Sophie Gangloff ◽  
Catherine Lavaud
Keyword(s):  
Antibacterial Activity ◽  
Methanolic Extract ◽  
Iridoid Glycosides ◽  
Folk Medicine ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Traditional Use ◽  
Triterpenoid Saponins ◽  
Methoxycinnamic Acid ◽  
New Compounds

AbstractFive new compounds, three iridoid glycosides (1-3) and two triterpenoid saponins (4, 5), along with thirty-two known compounds were isolated from the methanolic extract of the leaves of Dolichandrone spathacea. This traditional medicinal plant is widely used in Asia and India as antiseptic, for bronchitis and thrush treatment, and the methanolic extract has been shown to possess antibacterial activity against methicillin-resistant Staphylococcus aureus. The new iridoids were esterified derivatives of 6-ajugol and 6-catalpol, and the new saponins were glucosides of two polyhydroxy triterpenes with ursan skeleton. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR experiments and HR-ESI-MS analysis, and from comparison with the literature. This study aimed at investigating extracts and isolated compounds for their antimicrobial activities against bacterial and yeast strains, in order to validate the uses of the plant in folk medicine. The 6-O-esterified iridoids had weaker antibacterial activity; verbascoside and p-methoxycinnamic acid, the major compounds of the methanol extract, possessed strong antibacterial activity, which could account for the traditional antiseptic and anti-infectious uses of the leaves of D. spathacea.

Evaluation of Synergistic Antibacterial Effect of Combined Scrophularia striata Extract and Antibiotics Against Pseudomonas aeruginosa and Methicillin -Resistant Staphylococcus aureus

2021 ◽  
Vol 30 (2) ◽  
pp. 219-224
Author(s):  
Pari Tamri ◽  
Shabnam Pourmoslemi ◽  
Shirin Moradkhani ◽  
Sahar Foroughinia
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Synergistic Effect ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Folk Medicine ◽  
Additive Effects ◽  
Methicillin Resistant ◽  
Microdilution Method ◽  
Scrophularia Striata ◽  
New Compounds

Scrophularia. striata from Scrophulariacea family has been used in Iranian folk medicine for the treatment of infectious diseases. In this study we evaluated the synergistic effect of S. striata   hydroalcoholic extract (SSE) and commercially available antibiotics against P. aeroginosa and Methicillin- resistant Staphylococcus aureus (MRSA). The resazurin-based microdilution method was used to determine the minimum inhibitory concentration (MIC) values of plan extract and standard antibiotics. The interaction between standard antibiotics and SSE was evaluated by using checkerboard method. The results of this study revealed that SSE enhance the antibacterial activity of antibiotics. The combination of SSE and Vancomycin had synergistic to additive effects against MRSA.  SSE in combination with Gentamicin had synergistic to additive effects against P. aeruginosa. The interaction between Ceftazidime and SSE was additive against P. aeruginosa.  The best result was the synergistic effect between SSE and Piperacillin-Tazobactam against P. aeruginosa. In conclusion the results of this research indicated that S. striata has the potential to enhance the antibacterial activity of antibiotics and could be a source to the designing new compounds with synergistic effect in combination with standard antibiotics.

scholarly journals Flavonoids and Triterpenoid Saponins from Pimenta dioica (Merr.) L

2007 ◽  
Vol 2 (9) ◽  
pp. 1934578X0700200
Author(s):  
Fatma A. Moharram ◽  
Mona A Mohamed ◽  
Mohamed SA Marzouk ◽  
Elsayed A Aboutabl
Keyword(s):  
Methanolic Extract ◽  
2D Nmr ◽  
Physicochemical Analysis ◽  
Triterpenoid Saponins ◽  
Pimenta Dioica ◽  
First Time

The defatted and desalted 80% methanolic extract of the leaves of Pimenta dioica (Mirr.) L. resulted in the isolation of three triterpenoid saponins, 23-hydroxy-3α-[( O-α-L-rhamnopyranosyl-(1→2)- O-α-L-arabinopyranosyl) oxy] olean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)- O-β-D-galactopyranosyl-(1→6)- O-β-D-galactopyranosyl ester (1), 2α,3α,23-trihydroxyolean-12-en-28-oic acid O-β-D-glucopyranosyl ester (2), and 2α,3α,23-trihydroxyolean-13(18)-en-28-oic acid O-β-D-glucopyranosyl ester (3), along with a novel dihydrokaempferol glucoside, namely, 3-carboxy-6,8-di- C-methyl-dihydrokaempferol 3- O-β-D-glucopyranoside (4), together with three known flavonoids, quercetin 3- O-β-D-glucuronopyranoside (5), quercitrin (6) and mernesitin (7), all for the first time from the genus Pimenta. The structures were identified on the basis of chemical and physicochemical analysis (UV, HRESI-MS, 1 and 2D NMR).

scholarly journals Three New Cytotoxic Withanolides from the Chinese Folk Medicine Physalis angulata

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Cai-Yun Gao ◽  
Ting Ma ◽  
Jun Luo ◽  
Ling-Yi Kong
Keyword(s):  
Cell Line ◽  
Folk Medicine ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Spectroscopic Techniques ◽  
Aerial Parts ◽  
Physalis Angulata ◽  
The Absolute ◽  
New Compounds

Physagulides M-O, three new withanolides (1–3), were isolated from the aerial parts of Physalis angulata L. Their structures were elucidated through extensive spectroscopic techniques, including 1D and 2D NMR, and HRESIMS. The absolute configurations (22- R) of these new compounds were determined by CD analysis. Compounds 1 and 3 showed significant selective cytotoxic activities on the MG-63 cell line, with IC50 values of 4.28 and 5.44 μM, respectively.

scholarly journals ANTIMICROBIAL ACTIVITIES OF ARTABOTRYS ODORATISSIMUS R.Br.

2021 ◽  
Vol 3 (1) ◽  
pp. 1-5
Author(s):  
Poonam Sethi ◽  
Nandhagopal Karmegam
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Pseudomonas Fluorescens ◽  
Methanolic Extract ◽  
Antimicrobial Activities ◽  
Experimental Plant ◽  
Gram Negative Bacteria ◽  
Zone Of Inhibition ◽  
Gram Negative ◽  
Good Antibacterial Activity

ABSTRACT Artabotrys odoratissimus R.Br.  (Annonaceae) a medium sizes shrub with hooks, sweet smelling flowers and aggregate fruits, was tested for activity against gram negative bacteria. The fruit of the experimental plant was extracted with water, methanol and toluene: methanol (2:1 v/v). Artabotrys fruits showed good antibacterial activity and produced zone of inhibition of 32mm. The methanolic extract of the fruit showed maximum zone of inhibition at 300 ?g/ml against Pseudomonas fluorescens. The present study clearly indicates that A. odoratissimus had a profound antimicrobial   activity and it may be useful in the treatment of various infectious caused by bacteria. Keywords: Artabotrys, Gram Negative Bacteria, Pseudomonas, Zone Of Inhibition

New lupan-type triterpenoids

2016 ◽  
Vol 71 (11-12) ◽  
pp. 381-386 ◽  
Author(s):  
Pierre Mkounga ◽  
Hermine L.D. Maza ◽  
Blandine M.W. Ouahouo ◽  
Lydie N. Tyon ◽  
Hayato Ishikawa ◽  
...  
Keyword(s):  
Spectral Data ◽  
Manihot Esculenta ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
Wide Range ◽  
New Compounds ◽  
Chemical Evidence

Abstract Three new lupan-type triterpernoid derivatives, namely globimetulin A (1), B (2) and C (3), were isolated from the shoot of Globimetula dinklagei (Loranthaceae), a hemiparasitic plant growing on Manihot esculenta, along with five known compounds: friedelin (4), friedelan-3-ol (5), 28-hydroxyfriedelin (6), 4-hydroxy-3,5-dimethoxybenzoic acid (7) and (1R,5S,7S)-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one (8). The structures of the new compounds were elucidated by detailed analyses of their MS, IR, 1D and 2D NMR spectral data and chemical evidence. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms, but none of them exhibited noticeable activity.

Iridoid and Bisiridoid Glycosides from Globularia cordifolia

2003 ◽  
Vol 58 (5-6) ◽  
pp. 337-341 ◽  
Author(s):  
Hasan Kirmizibekmez ◽  
Ihsan Çaliş ◽  
Pinar Akbay ◽  
Otto Sticher
Keyword(s):  
Nmr Spectroscopy ◽  
Methanolic Extract ◽  
Iridoid Glycosides ◽  
2D Nmr ◽  
Iridoid Glycoside ◽  
2D Nmr Spectroscopy

Abstract From the methanolic extract of the underground parts of Globularia cordifolia, a new iridoid glycoside, 5-hydroxydavisioside (1) and a new bisiridoid glycoside, globuloside C (2) were isolated along with six known iridoid glycosides, aucubin, melampyroside, monomelittoside, globularifolin, alpinoside and asperuloside. The structures of the isolates were established by 1D and 2D NMR spectroscopy in combination with IR, UV and MS analyses.

scholarly journals Triterpenoids from Aerial Parts of Glochidion eriocarpum

2010 ◽  
Vol 5 (3) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Vu Kim Thu ◽  
Phan Van Kiem ◽  
Pham Hai Yen ◽  
Nguyen Xuan Nhiem ◽  
Nguyen Huu Tung ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Chromatographic Separations ◽  
Triterpenoid Saponins ◽  
Fticr Ms ◽  
Aerial Parts ◽  
New Compounds

From the aerial parts of Glochidion eriocarpum, a new triterpene, glochieriol (1), three new triterpenoid saponins, glochieriosides C - E (2 - 4), together with four known triterpenes (glochidonol, glochidiol, lupeol, and 3- epi-lupeol) were isolated by using combined chromatographic separations. The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR.

Isolation, characterisation and antibacterial activity of new compounds from methanolic extract of seeds ofCaesalpinia cristaL. (Caesalpinaceae)

2013 ◽  
Vol 28 (4) ◽  
pp. 230-238 ◽  
Author(s):  
Ankit Kumar ◽  
Vikas Garg ◽  
Anurag Chaudhary ◽  
Pankaj Kumar Jain ◽  
Praveen Kumar Tomar
Keyword(s):  
Antibacterial Activity ◽  
Methanolic Extract ◽  
New Compounds

Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

2020 ◽  
Vol 16 ◽  
Author(s):  
Ameen Ali Abu-Hashem ◽  
Hoda A. R. Hussein ◽  
Ahmed S. Aly
Keyword(s):  
2D Nmr ◽  
Antimicrobial Activities ◽  
New Drugs ◽  
Pharmacological Activities ◽  
Efficient System ◽  
Wide Range ◽  
Nmr Techniques ◽  
Analgesic Activities ◽  
New Compounds

Background: Previous and recent scientific research has shown that triazolopyrimidine and furochromones have a wide range of pharmacological activities in the treatment of numerous diseases, including anticancer, antiviral, anti-depressant, antimicrobial, anti-inflammatory, and analgesic activities. Objective: Preparation of new drugs used as antimicrobial activities derived from a natural furochromones as (1- hydrazinyl or methylthio),-furopyrimidoquinazolinone, 1, 2, 4-triazolopyrimidofuroquinazolin-5-one, and quinazolinepyrimidofuro- quinazoline-8, 10-dione and study of their biological activity as antimicrobial. Method: A series of novel N’-furopyrimidoquinazoline-hydrazide; 1, 2, 4-triazolopyrimidofuroquinazolin-5-one; furopyrimidoquinazolin-3-one and quinazoline-pyrimidofuroquinazoline-8, 10-dione derivatives were synthesized from substituted (methylthio)-furopyrimidoquinazolinone (3a-b) and 1-hydrazinyl-furopyrimidoquinazolinone (4a-b) as the starting material. Results: All compounds were synthesized in good yields (71-95%) in a gradually efficient system under the mild condition and some of the procedures were used a microwave oven. The new compounds have been confirmed by means of different spectroscopic ways such as IR, 1D and 2D -NMR techniques and mass spectrum. The in vitro to antimicrobial activities were evaluated for the prepared compounds using many types of bacteria (Gram positive and Gram negative) and fungi. Conclusion: 1, 2, 4-triazolopyrimidofuroquinazolin-5-one derivatives (10a-f, 8a-b, 7a-b and 6a-d) showed the most efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.

scholarly journals A New Iridoid from the Aerial Parts of Hedyotis Pilulifera

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100
Author(s):  
Nguyen Thi Hoai ◽  
Ho Viet Duc ◽  
Nguyen Dinh Quynh Phu ◽  
Takeshi Kodama ◽  
Takuya Ito ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Iridoid Glycosides ◽  
Bacterial Species ◽  
2D Nmr ◽  
Spectral Analyses ◽  
Esi Ms ◽  
Aerial Parts ◽  
Nmr Data ◽  
Mic Value

A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2–6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1–6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 μg/mL.

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