Background:
Previous and recent scientific research has shown that triazolopyrimidine and furochromones
have a wide range of pharmacological activities in the treatment of numerous diseases, including anticancer, antiviral,
anti-depressant, antimicrobial, anti-inflammatory, and analgesic activities.
Objective:
Preparation of new drugs used as antimicrobial activities derived from a natural furochromones as (1-
hydrazinyl or methylthio),-furopyrimidoquinazolinone, 1, 2, 4-triazolopyrimidofuroquinazolin-5-one, and quinazolinepyrimidofuro- quinazoline-8, 10-dione and study of their biological activity as antimicrobial.
Method:
A series of novel N’-furopyrimidoquinazoline-hydrazide; 1, 2, 4-triazolopyrimidofuroquinazolin-5-one; furopyrimidoquinazolin-3-one and quinazoline-pyrimidofuroquinazoline-8, 10-dione derivatives were synthesized from
substituted (methylthio)-furopyrimidoquinazolinone (3a-b) and 1-hydrazinyl-furopyrimidoquinazolinone (4a-b) as the
starting material.
Results:
All compounds were synthesized in good yields (71-95%) in a gradually efficient system under the mild
condition and some of the procedures were used a microwave oven. The new compounds have been confirmed by means
of different spectroscopic ways such as IR, 1D and 2D -NMR techniques and mass spectrum. The in vitro to antimicrobial
activities were evaluated for the prepared compounds using many types of bacteria (Gram positive and Gram negative)
and fungi.
Conclusion:
1, 2, 4-triazolopyrimidofuroquinazolin-5-one derivatives (10a-f, 8a-b, 7a-b and 6a-d) showed the most
efficient antimicrobial activities compared with the cefotaxime sodium and nystatin as standard drugs.