The Role of Ras Proteins in Insulin Signal Transduction

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1) is known to function as a negative feedback regulator of cytokine signaling, but it is unclear whether it is involved in other biological events. Here, we show that SSI-1 participates and plays an important role in the insulin signal transduction pathway. SSI-1–deficient mice showed a significantly low level of blood sugar. While the forced expression of SSI-1 reduced the phosphorylation level of insulin receptor substrate 1 (IRS-1), SSI-1 deficiency resulted in sustained phosphorylation of IRS-1 in response to insulin. Furthermore, SSI-1 achieves this inhibition both by binding directly to IRS-1 and by suppressing Janus kinases. These findings suggest that SSI-1 acts as a negative feedback factor also in the insulin signal transduction pathway through the suppression of IRS-1 phosphorylation.

Download Full-text

Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues

Molecular and Cellular Endocrinology ◽

10.1016/s0303-7207(97)00071-3 ◽

1997 ◽

Vol 130 (1-2) ◽

pp. 33-42 ◽

Cited By ~ 41

Author(s):

Ana C.P Thirone ◽

Carla R.O Carvalho ◽

Sigisfredo L Brenelli ◽

Lı́cio A Velloso ◽

Mario J.A. Saad

Keyword(s):

Signal Transduction ◽

Growth Hormone ◽

Growth Hormone Treatment ◽

Hormone Treatment ◽

Rat Tissues ◽

Insulin Signal Transduction ◽

Insulin Signal

Download Full-text

Insulin Signal Transduction by a Mutant Human Insulin Receptor Lacking the NPEY Sequence

Journal of Biological Chemistry ◽

10.1074/jbc.272.36.22884 ◽

1997 ◽

Vol 272 (36) ◽

pp. 22884-22890 ◽

Cited By ~ 11

Author(s):

Paulos Berhanu ◽

Celia Anderson ◽

Matt Hickman ◽

Theodore P. Ciaraldi

Keyword(s):

Signal Transduction ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Signal Transduction ◽

Insulin Signal ◽

Human Insulin Receptor

Download Full-text

Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.

Molecular Endocrinology ◽

10.1210/mend.10.5.8732688 ◽

1996 ◽

Vol 10 (5) ◽

pp. 575-584 ◽

Cited By ~ 1

Author(s):

W R Zhang ◽

P M Li ◽

M A Oswald ◽

B J Goldstein

Keyword(s):

Signal Transduction ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Receptor Type ◽

Protein Tyrosine ◽

Insulin Signal Transduction ◽

Insulin Signal ◽

Type Protein

Download Full-text

Association between Risk Factors for Vascular Dementia and Adiponectin

BioMed Research International ◽

10.1155/2014/261672 ◽

2014 ◽

Vol 2014 ◽

pp. 1-13 ◽

Cited By ~ 17

Author(s):

Juhyun Song ◽

Won Taek Lee ◽

Kyung Ah Park ◽

Jong Eun Lee

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Signal Transduction ◽

Vascular Dementia ◽

Case Control ◽

Case Control Studies ◽

Insulin Signal Transduction ◽

Increased Risk ◽

The Brain

Vascular dementia is caused by various factors, including increased age, diabetes, hypertension, atherosclerosis, and stroke. Adiponectin is an adipokine secreted by adipose tissue. Adiponectin is widely known as a regulating factor related to cardiovascular disease and diabetes. Adiponectin plasma levels decrease with age. Decreased adiponectin increases the risk of cardiovascular disease and diabetes. Adiponectin improves hypertension and atherosclerosis by acting as a vasodilator and antiatherogenic factor. Moreover, adiponectin is involved in cognitive dysfunction via modulation of insulin signal transduction in the brain. Case-control studies demonstrate the association between low adiponectin and increased risk of stroke, hypertension, and diabetes. This review summarizes the recent findings on the association between risk factors for vascular dementia and adiponectin. To emphasize this relationship, we will discuss the importance of research regarding the role of adiponectin in vascular dementia.

Download Full-text