Blood Concentrations of Glucose, Insulin and Free Fatty Acids in Shortly Thyroxine-Treated Dogs: Effects of Alpha-Blockade and Isoproterenol

1982 ◽  
Vol 14 (02) ◽  
pp. 101-101 ◽  
Author(s):  
Aurora Renauld ◽  
R. Sverdlik ◽  
R. Rodriguez
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Blood Concentrations ◽  
Alpha Blockade

scholarly journals Free Fatty Acids Inhibit Growth Hormone/Signal Transducer and Activator of Transcription-5 Signaling in Human Muscle: A Potential Feedback Mechanism

2009 ◽  
Vol 30 (3) ◽  
pp. 289-289
Author(s):  
Niels Møller ◽  
Lars C. Gormsen ◽  
Ole Schmitz ◽  
Sten Lund ◽  
Jens Otto L. Jørgensen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Negative Feedback ◽  
Feedback Inhibition ◽  
Research Unit ◽  
Feedback Mechanism ◽  
Signal Transducer ◽  
Blood Concentrations ◽  
Clinical Research Unit

ABSTRACT Context: Stimulation of lipolysis, leading to increased blood concentrations of free fatty acids (FFAs), is a primary effect of GH and phosphorylation of intracellular signal transducer and activator of transcription (STAT)-5 is a primary mediator of the effects of GH. Objective: Based on preliminary results, we intended to test whether FFAs exert a negative feedback inhibition of STAT5 phosphorylation in skeletal muscle. Design and Participants: Eight healthy young men were investigated for 8 h on four occasions at four different FFA levels in a single blind, randomized manner. Acipimox was used to suppress FFA levels and Intralipid was infused to obtain appropriate FFA concentrations. Somatostatin was infused to control GH levels and GH, insulin, and glucagon were replaced. Muscle biopsies were taken after 8 h and compared with a fifth biopsy taken under normal basal conditions. Setting: The study was conducted at a university clinical research unit. Results: GH concentrations remained steady and comparable in all studies and FFA concentrations varied between 0.01 and 1.71 mmol/liter on the four occasions (P < 0.05). We observed a dose-dependent 40% decrease of STAT5 phosphorylation in skeletal muscle with increasing concentrations of FFAs. Conclusions: Our results strongly suggest the existence of a negative feedback loop, whereby effects of GH may be dampened by FFA inhibition of GH-dependent STAT5 phosphorylation. The mechanisms behind and biological consequences of this finding awaits additional studies.

scholarly journals Blood concentrations of thyroid hormones and lipids and histological changes in the liver in dairy cows in post-parturient period

2009 ◽  
Vol 63 (5-6) ◽  
pp. 285-297
Author(s):  
Radojica Djokovic
Keyword(s):  
Fatty Acids ◽  
Thyroid Hormones ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Histological Changes ◽  
Blood Concentrations ◽  
Thyroidal Status ◽  
Biochemical Examination

The triiodthyronine (T3), thyroxine (T4), glucose, free fatty acids (FFA), triacylglycerols (TAG) and total cholesterol concentrations were estimated in the blood serum and content of lipids in the liver in healthy (n=10) and ketotic (n=10) dairy cows in the post parturient period. Samples of liver and blood tissues were taken from all the cows. Pathohistoligical examination of liver tissues showed statistically significant higher (p<0.01) lipid infiltration in ketotic cows compared to healthy ones. Biochemical examination of blood serum showed significantly higher values (p<0.01) of free fatty acids in ketotic cows such as significantly lower concentrations of glucose (p<0.01), triacylglycerols (p<0.01), total cholesterol (p<0.05), triiodthyronine (p<0.05) and thyroxine (p<0.05) compared to values of these parameters in the blood serum in healthy cows. Significant increase of concentration of free fatty acids, such as positive correlation (r=0.51; p<0.05) between the free fatty acids in blood and the content of lipids in liver in ketotic cows compared to healthy ones, as well as pathohistological report, shows that during intensive lipomobilisation newly synthesized triacylglycerols accumulated in the hepatocytes. In ketotic cows hypo thyroidal status is established and it can be a significant factor in the development of fatty liver. .

scholarly journals Blood Concentrations of Thyroid Hormones and Lipids and Content of Lipids in the Liver of Dairy Cows in Transitional Period

2007 ◽  
Vol 76 (4) ◽  
pp. 525-532 ◽  
Author(s):  
R. Djoković ◽  
H. Šamanc ◽  
M. Jovanović ◽  
Z. Nikolić
Keyword(s):  
Fatty Acids ◽  
Thyroid Hormones ◽  
Blood Serum ◽  
Free Fatty Acids ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Clinical Symptoms ◽  
Liver Steatosis ◽  
Transitional Period ◽  
Blood Concentrations

The aim of the present investigation was to determine the correlation in the blood concentrations of thyroid hormones, lipids and glucose as well as the content of lipids in the liver of dairy cows in the transitional period. The animals (n = 40) were divided into four groups: the first group included late pregnant cows (n = 10) from the 10th to 4th day before calving; the second group included late pregnant cows (n = 10) from the 4th to 1st day before calving; the third group included clinically puerperal healthy cows (n = 10), whereas the fourth group included puerperal cows with clinical symptoms of ketosis (n = 10). Samples of liver and blood tissues were taken from all cows. Pathohistological examination of liver samples showed statistically significantly higher (p < 0.01) lipid infiltration in ketotic cows compared to healthy cows in late pregnancy and puerperium. Biochemical examination of blood serum showed significantly higher values (p < 0.01) of free fatty acids in ketotic cows, such as significantly lower blood concentrations of glucose (p < 0.01), triacylglycerols (p < 0.01), total cholesterol (p < 0.05), triiodthyronine (p < 0.05) and thyroxine (p < 0.05), compared to the values obtained in the blood serum in the groups of healthy cows before and after calving. In this study, significantly positive correlations were determined between the content of lipids in the liver and blood concentration of free fatty acids (r = 0.51; p < 0.05) as well as the negative ones between the content of lipids in the liver and blood concentrations of glucose (r = -0.69; p < 0.05), triacylglycerols (r = -0.55; p < 0.05) and total cholesterol (r = -0.50; p < 0.05) in the group of ketotic cows. Our investigations suggested that a hypothyroidal status was established in ketotic cows and that the blood concentrations of free fatty acids, triacylglycerols, total cholesterol and glucose served as major biochemical indicators in determining liver steatosis in the dairy cows in the transitional period.

GENERAL EFFECTS OF α-MELANOCYTE STIMULATING HORMONE IN THE RABBIT

1965 ◽  
Vol 48 (4) ◽  
pp. 609-618 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Systemic Effects ◽  
List Type ◽  
Aqueous Flare ◽  
Melanocyte Stimulating Hormone ◽  
Blood Aqueous Barrier

ABSTRACT In addition to the previously described permeability disturbance in the blood aqueous barrier of the eye, measured as an increase of the aqueous flare, a series of transitory systemic effects have been recorded following the subcutaneous injection of synthetic α-MSH: marked increase of the free fatty acids in plasma, decrease in the serum calcium level, decrease in the blood pressure, increase in the skin temperature, increased frequency and diminished amplitude of respiration, presence of slow waves in the EEG. There is a correlation between the magnitude of the aqueous flare increase and the increase of free fatty acids in plasma and also between the aqueous flare and the minimum serum calcium level.

The Relationship of Fasting Free Fatty Acids, Adipose Tissue, Insulin Resistance, and Fasting Glucose Concentrations with Subsequent ß-Cell Function in Nondiabetic Subjects

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1812-P
Author(s):  
MARIA D. HURTADO ◽  
J.D. ADAMS ◽  
MARCELLO C. LAURENTI ◽  
CHIARA DALLA MAN ◽  
CLAUDIO COBELLI ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Free Fatty Acids ◽  
Cell Function ◽  
Fasting Glucose ◽  
Relationship Of ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document