The Leptin-Fat Ratio is Constant, and Leptin May be Part of Two Feedback Mechanisms for Maintaining the Body Fat Set Point in Non-Obese Male Fischer 344 Rats

1999 ◽  
Vol 31 (09) ◽  
pp. 525-532 ◽  
Author(s):  
J. Greenberg ◽  
C. Boozer
Keyword(s):  
Body Fat ◽  
The Body ◽  
Fischer 344 Rats ◽  
Feedback Mechanisms ◽  
Set Point ◽  
Fischer 344 ◽  
Obese Male

Adjusted and unadjusted energy usage rates both determine body fat and plasma leptin in male Fischer 344 rats

Metabolism ◽  
1999 ◽  
Vol 48 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
James A. Greenberg ◽  
Shah Rahman ◽  
Sandra Saint-Preux ◽  
David R. Owen ◽  
Carol N. Boozer
Keyword(s):  
Body Fat ◽  
Fischer 344 Rats ◽  
Energy Usage ◽  
Fischer 344 ◽  
Plasma Leptin ◽  
Usage Rates

Toxic effects of inhaled DMMP on the kidneys of Fischer-344 rats

1987 ◽  
Vol 45 ◽  
pp. 880-881
Author(s):  
D.R. Mattie ◽  
C.J. Hixson
Keyword(s):  
Left Kidney ◽  
Inhalation Exposure ◽  
Electron Microscopic Examination ◽  
Exposure Period ◽  
Male Rats ◽  
Continuous Exposure ◽  
Fischer 344 Rats ◽  
Electron Microscopic ◽  
Thin Sections ◽  
Fischer 344

Dimethylmethylphosphonate (DMMP) is a simple organophosphate used industrially as a flame retardant and to lower viscosity in polyester and epoxy resins. The military considered the use of DMMP as a nerve gas simulant. Since military use of DMMP involved exposure by inhalation, there was a need for a subchronic inhalation exposure to DMMP to fully investigate its toxic potential.Male Fischer-344 rats were exposed to 25 ppm or 250 ppm DMMP vapor on a continuous basis for 90 days. An equal number of control rats were sham-exposed. Following the 90-day continuous exposure period, 15 male rats were sacrificed from each group. Two rats from each group had the left kidney perfused for electron microscopic examination. The kidneys were perfused from a height of 150 cm water with 1% glutaraldehyde in Sorensen's 0.1M phosphate buffer pH 7.2. An additional kidney was taken from a rat in each group and fixed by immersion in 2.5% glutaraldehyde and 2% paraformaldehyde in 0.1M cacodylate buffer pH 7.4. A portion of the 9 kidneys collected for electron microscopy were processed into Epon 812. Thin sections, stained with uranyl acetate and lead citrate, were examined with a JEOL 100B Transmission Electron Microscope. Microvilli height was measured on photographs of the cells of proximal tubules. This data, along with morphologic features of the cells, allows the proximal convoluted tubules (PCT) to be identified as being S1, S2, or S3 segment PCT.

Ultrastructure of rat alveolar macrophages activated in situ by poly:IC

1987 ◽  
Vol 45 ◽  
pp. 768-769
Author(s):  
A. M. Klinkner ◽  
R. A. Weiss ◽  
A. Kelley ◽  
P. J. Bugelski
Keyword(s):  
Venous Blood ◽  
Intratracheal Instillation ◽  
Buffy Coat ◽  
Fischer 344 Rats ◽  
Blood Monocytes ◽  
Fischer 344 ◽  
Polyinosinic:Polycytidylic Acid ◽  
Macrophage Activator ◽  
Endogenous Peroxidase

Polyinosinic:polycytidylic acid is an inducer of interferon and a macrophage activator. We have found that intratracheal instillation of polyI:C (IT-pI:C) activates rat bronchoalveolar lavage cells (BAL) for a variety of functions. Examination of Giemsa stained, cytocentrifuge preparations showed that IT-pI:C induced a population of BAL not seen in resident BAL. The morphology of these cells suggested that they might be derived from blood monocytes. To test this hypothesis we have examined several populations of macrophages that had been stained for endogenous peroxidase activity as a marker of cells derived from the monocyte-macrophage lineage.Macrophages were obtained from Fischer 344 rats. Peritoneal exudate cells (PEC) were collected by lavage 4 days after i.p. injection of 20 ml 3% thioglycolate. Buffy coat monocytes were separated from venous blood from naive rats.

Pengaruh Senam Diabetes Mellitus terhadap Persentase Lemak Tubuh Penderita DM Tipe II di Puskesmas Godean I

2017 ◽  
Vol 19 (1) ◽  
pp. 51-55
Author(s):  
Dyda Fahmi Fadhilah ◽  
Nurul Huda Syamsiatun ◽  
Idi Setiyobroto
Keyword(s):  
Diabetes Mellitus ◽  
Local Government ◽  
Body Fat ◽  
Fat Body ◽  
Disease Risk ◽  
Psychological Intervention ◽  
The Body ◽  
Type Ii ◽  
Paired Sample ◽  
Government Clinic

Background : The number of DM victims in the world increased year by year. According to Health Elementary Research in 2013  the highest number was in DIY, it was 2,6%. Then, according to Godean I Local Government Clinic data, DM was the second rank of Non-Communicable Disease (NCD) after hypertension. The increasing of DM victims number was connected by the overweight case that was influenced by unhealthy diet and lack ofphysic activities so it caused accumulation of fat tissues. In the next time it can cause complication for the victims. There are three pillars of DM management namely, diet, psychological intervention, and exercises. The first that should be done is exercises. One of them is physic exercises namely DM gymnastic. Its functions are to control blood sugar, lose weight and body fat so cardiovascular disease risk factor can be prevented and fixed. In this research the DM gymnastic was done three times in a week for six weeks in duration time of 30-60 minutes. Objective : Purpose of the research to know the influence of DM gymnastic to the change of fat body percentage of DM type II victims in Godean I Local Government Clinic. Method : Research method this research used quasi-experiment method, the research plan used pre-post design. The population was all of DM type II victims in Godean I Local Government Clinic with the subject number were 24 people. The data analysis used statistic test Paired Sample t Test with the credibility 95%. Result : Result of the research the statistic test Paired Sample t Ttest showed that there were not differences before and after DM gymnastic treatment for six weeks. According to the average of fat body percentage after DM gymnastic treatment was higher than before (32,52% > 32,86%). Conclusion : There was no influence of DM gymnastic to the body fat percentage of DM type II victims in GodeanI Local Government Clinic p = 0,59 or p = >0,05.   Keywords: Gymnastic, Diabetes Mellitus, Fat Body Percentage

Relationship between Insulin Sensitivity and Body Fat Composition, and Leptin Sensitivity in Non-Obese and Overweight/Obese Adults

2019 ◽  
Vol 31 (3) ◽  
pp. 212-218
Keyword(s):  
Insulin Sensitivity ◽  
Body Fat ◽  
Negative Relationship ◽  
The Body ◽  
Sensitivity Index ◽  
Moderate Degree ◽  
Model Assessment ◽  
Obese Adults ◽  
Leptin Sensitivity ◽  
Fat Composition

Both insulin and leptin are major contributors for the body energy balance. Obesity is a state of energy imbalance and is also associated with changes in both insulin sensitivity and leptin sensitivity. The aim of this study was to find out the relationship between insulin sensitivity and body fat composition, and leptin sensitivity in non-obese and obese adults. A total of 86 adults participated: 42 non-obese and 44 over-weight/obese. Body fat (BF) percent was determined by skinfold method. Fasting plasma glucose was analyzed by glucose oxidase-phenol and 4 aminophenazone (GOD-PAP) method using spectro-photometer, fasting serum insulin and leptin concentrations by direct sandwich ELISA method and resting energy expenditure (REE) by indirect calorimetry. Leptin sensitivity index and insulin sensitivity were expressed as REE : Leptin ratio and homeostatic model assessment-insulin resistance (HOMA-IR), respectively. It was found that median value of HOMA-IR was significantly higher [2.93 vs 1.72, p<0.01] and leptin sensitivity was significantly lower [116.76 vs 265.66, p<0.001] in the overweight/obese adults than the non-obese adults, indicating that insulin sensitivity and leptin sensitivity were markedly reduced in overweight/obese adults in compare to non-obese adults. There was a moderate degree of positive relationship between HOMA-IR and BF only in the overweight/obese (ρ=0.509, n=44, p<0.001) and all adults (ρ=0.39, n=86, p<0.001). Similarly, a weak negative relationship between leptin sensitivity index and HOMA-IR was found in the overweight/obese (ρ=-0.328, n=44, p<0.05) and all adults (ρ=-0.35, n=86, p<0.01). It can be concluded that the insulin sensitivity was adiposity dependent, but, it did not depend on leptin sensitivity.

The Effect of Feeding Date Palm Fruit (Phoeix dactylifera L.) on Energy, Macronutrient, and Fiber Intakes of a Convenient Sample of Females

2020 ◽  
Vol 16 (8) ◽  
pp. 1270-1277
Author(s):  
Hiba F. Al-Sayyed ◽  
Hamed R. Takruri ◽  
Nawal A. Bakir ◽  
Dima H. Takruri
Keyword(s):  
Body Weight ◽  
Body Fat ◽  
Date Palm ◽  
The Body ◽  
Control Group ◽  
Hormone Concentration ◽  
Palm Fruit ◽  
Menstrual Status ◽  
Feeding Duration ◽  
Effect Of Feeding

Background : Female menstrual changes in hormone concentration influence appetite and eating behavior. As well, eating pattern has some influences on menstrual hormonal status. Feeding date palm fruit has been found in our previous report to affect menstrual hormones and some menstrual parameters. Objective: The aim of this research is to study the effect of feeding dates on energy, macronutrient, and fiber intakes, body weight, and body fat%. Additionally, this study aims to find any correlation between menstrual hormone concentration and the above-mentioned parameters. Methods: A convenient sample (n=37) of not-sexually active females aged 20-30 were divided into two groups; one group (dates group) was fed 7 dates and the other served as a control group. The participants of the control group were exposed to the same experimental conditions except for eating dates. Throughout the feeding trial, the volunteers filled a 3-day food record; one menses day and two non-menses days. Results: There was a significant effect of the menstrual status-feeding duration interaction in terms of protein and fat intakes. Additionally, menstrual status, as well as feeding duration, affected energy and macronutrient intakes significantly. Furthermore, feeding duration affected fiber intake significantly. Despite the above-mentioned differences in energy and macronutrient intakes, these effects didn’t affect the body weight and body mass index of the study participants, neither their body fat%. Moreover, we have found significant correlations between nutrient intakes and menstrual hormone concentration. Conclusion : Feeding dates affected energy, macronutrient, and fiber intakes significantly. These effects were related to the changes in menstrual hormone concentration.

scholarly journals Wrist-wearable bioelectrical impedance analyzer with miniature electrodes for daily obesity management

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Myoung Hoon Jung ◽  
Kak Namkoong ◽  
Yeolho Lee ◽  
Young Jun Koh ◽  
Kunsun Eom ◽  
...  
Keyword(s):  
Contact Resistance ◽  
Body Fat ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Upper Body ◽  
Sensor Technology ◽  
Clinical Test ◽  
Obesity Management ◽  
Impedance Analyzer ◽  
Bioelectrical Impedance Analyzer

AbstractBioelectrical impedance analysis (BIA) is used to analyze human body composition by applying a small alternating current through the body and measuring the impedance. The smaller the electrode of a BIA device, the larger the impedance measurement error due to the contact resistance between the electrode and human skin. Therefore, most commercial BIA devices utilize electrodes that are large enough (i.e., 4 × 1400 mm2) to counteract the contact resistance effect. We propose a novel method of compensating for contact resistance by performing 4-point and 2-point measurements alternately such that body impedance can be accurately estimated even with considerably smaller electrodes (outer electrodes: 68 mm2; inner electrodes: 128 mm2). Additionally, we report the use of a wrist-wearable BIA device with single-finger contact measurement and clinical test results from 203 participants at Seoul St. Mary’s Hospital. The correlation coefficient and standard error of estimate of percentage body fat were 0.899 and 3.76%, respectively, in comparison with dual-energy X-ray absorptiometry. This result exceeds the performance level of the commercial upper-body portable body fat analyzer (Omron HBF-306). With a measurement time of 7 s, this sensor technology is expected to provide a new possibility of a wearable bioelectrical impedance analyzer, toward obesity management.

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