123-I-ADAM-SPECT Imaging of Serotonin Transporters in Depressed Patients -Impact of gender to the relationship between SERT and psychopathological symptoms

The incidence of cognitive impairment in TBI is high, depending on the severity. At the same time, psychopathological symptoms in the form of asthenia, increased anxiety and depression are encountered among patients with TBI. The work studied the relationship between cognitive and psychopathological symptoms in patients with TBI using neuropsychological testing on scales.

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Methylome-wide change associated with response to electroconvulsive therapy in depressed patients

Translational Psychiatry ◽

10.1038/s41398-021-01474-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Lea Sirignano ◽

Josef Frank ◽

Laura Kranaster ◽

Stephanie H. Witt ◽

Fabian Streit ◽

...

Keyword(s):

Electroconvulsive Therapy ◽

Rating Scale ◽

Antidepressant Treatment ◽

Cpg Sites ◽

Cpg Site ◽

Depressed Patients ◽

Resistant Depression ◽

Functional Pathway ◽

Regional Analyses ◽

The Relationship

AbstractElectroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment considered to be effective in treating severe and pharmacotherapy-resistant forms of depression. Recent studies have suggested that epigenetic mechanisms can mediate treatment response and investigations about the relationship between the effects of ECT and DNA methylation have so far largely taken candidate approaches. In the present study, we examined the effects of ECT on the methylome associated with response in depressed patients (n = 34), testing for differentially methylated CpG sites before the first and after the last ECT treatment. We identified one differentially methylated CpG site associated with the effect of ECT response (defined as >50% decrease in Hamilton Depression Rating Scale score, HDRS), TNKS (q < 0.05; p = 7.15 × 10−8). When defining response continuously (ΔHDRS), the top suggestive differentially methylated CpG site was in FKBP5 (p = 3.94 × 10−7). Regional analyses identified two differentially methylated regions on chromosomes 8 (Šídák’s p = 0.0031) and 20 (Šídák’s p = 4.2 × 10−5) associated with ΔHDRS. Functional pathway analysis did not identify any significant pathways. A confirmatory look at candidates previously proposed to be involved in ECT mechanisms found CpG sites associated with response only at the nominally significant level (p < 0.05). Despite the limited sample size, the present study was able to identify epigenetic change associated with ECT response suggesting that this approach, especially when involving larger samples, has the potential to inform the study of mechanisms involved in ECT and severe and treatment-resistant depression.

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THE RELATIONSHIP BETWEEN OBJECTIVELY MEASURED STEP COUNT, CLINICAL CHARACTERISTICS, AND QUALITY OF LIFE AMONG DEPRESSED PATIENTS RECENTLY HOSPITALIZED WITH SYSTOLIC HEART FAILURE

Psychosomatic Medicine ◽

10.1097/psy.0000000000001034 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Julia P. Holber ◽

Kaleab Z. Abebe ◽

Yan Huang ◽

John M. Jakicic ◽

Amy M. Anderson ◽

...

Keyword(s):

Quality Of Life ◽

Heart Failure ◽

Clinical Characteristics ◽

Systolic Heart Failure ◽

Step Count ◽

Depressed Patients ◽

Objectively Measured ◽

The Relationship

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Hippocampal volume and subjective memory impairment in depressed patients

European Psychiatry ◽

10.1016/j.eurpsy.2004.05.003 ◽

2004 ◽

Vol 19 (7) ◽

pp. 438-440 ◽

Cited By ~ 20

Author(s):

Armin von Gunten ◽

Maria A. Ron

Keyword(s):

Memory Impairment ◽

Hippocampal Volume ◽

Subjective Memory ◽

Subjective Memory Impairment ◽

Depressed Patients ◽

The Right ◽

The Relationship

AbstractThe relationship between severity of subjective memory impairment and volume of the hippocampus/amygdala complex was investigated in non-demented depressed patients and it was found to correlate with decreasing volume in the right hippocampus.

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P300 event-related brain potential and personality in depression

European Psychiatry ◽

10.1016/s0924-9338(00)00505-8 ◽

2000 ◽

Vol 15 (6) ◽

pp. 370-377 ◽

Cited By ~ 14

Author(s):

M. Hansenne ◽

W. Pitchot ◽

E. Pinto ◽

J Reggers ◽

P. Papart ◽

...

Keyword(s):

Statistical Significance ◽

Normal Subjects ◽

P300 Amplitude ◽

Temperament And Character Inventory ◽

Brain Potential ◽

Depressed Patients ◽

Character Inventory ◽

Positive Correlations ◽

Psychotic Features ◽

The Relationship

summaryP300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect, suicidal behavior and psychotic features significantly influence P300 amplitude. However, no data are available on the possible influences of the personality of depressed patients on P300. Since personality is related to P300 in normal subjects, the aim of the present study is to investigate the relationship between ERPs (P200, N200, and P300) and the Temperament and Character Inventory (TCI) in 54 depressed patients. The main results of the study concern the absence of major correlations between personality dimensions as assessed by the TCI and ERP parameters among depressed patients. Only weak partial positive correlations relate N200 latency with harm avoidance, and P300 amplitude (Pz) with the self-directedness dimension. N200 amplitude is also negatively correlated to persistence. However, the preliminary nature of the presented results with respect to the weak statistical significance should be underlined.

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The Relationship between Dog Ownership, Psychopathological Symptoms and Health-Benefitting Factors in Occupations at Risk for Traumatization

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072562 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2562 ◽

Cited By ~ 2

Author(s):

Johanna Lass-Hennemann ◽

Sarah K. Schäfer ◽

M. Roxanne Sopp ◽

Tanja Michael

Keyword(s):

Mental Health ◽

Police Officers ◽

Mental Health Problems ◽

Health Problems ◽

Pet Ownership ◽

Cross Sectional Survey ◽

Psychopathological Symptoms ◽

Positive Effects ◽

Dog Owners ◽

The Relationship

Individuals working in high-risk occupations (e.g., emergency staff) are exposed to high levels of occupational stress including traumatic events. Correspondingly, several studies report high rates of mental health problems among these occupations. Pet ownership has been associated with better mental health. However, to date a study on the association between pet ownership and indicators of mental health in these occupations is missing. The present cross-sectional survey (N = 580) investigated pet ownership, attachment to pets, health-benefitting factors (i.e., sense of coherence, trait-resilience, locus of control) and psychopathological symptoms (i.e., general mental health problems, posttraumatic stress, burnout) in medical staff, police officers, and firefighters. Dog owners and non-dog owners showed comparable levels of psychopathological distress and health-benefitting factors. Compared to cat owners, dog owners demonstrated stronger emotional attachment to their pet. Moreover, a stronger attachment was also linked to higher levels of psychopathological symptoms and lower levels of health-benefitting factors. However, the relationship between attachment to pets and health-benefitting factors could be explained by their overlap with psychopathological symptom levels. Overall, our findings are not in line with the notion that pet ownership generally has a health-benefitting effect. Future studies need to investigate circumstances that modulate positive effects of pet ownership.

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The relationship of self-compassion and depression: Cross-lagged panel analyses in depressed patients after outpatient therapy

Journal of Affective Disorders ◽

10.1016/j.jad.2016.05.032 ◽

2016 ◽

Vol 202 ◽

pp. 39-45 ◽

Cited By ~ 38

Author(s):

Tobias Krieger ◽

Thomas Berger ◽

Martin grosse Holtforth

Keyword(s):

Outpatient Therapy ◽

Depressed Patients ◽

Self Compassion ◽

Relationship Of ◽

The Relationship

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The Relationship between Genetic and Precipitating Factors in Depressive Illness

The British Journal of Psychiatry ◽

10.1192/s0007125000001318 ◽

1972 ◽

Vol 121 (560) ◽

pp. 67-70 ◽

Cited By ~ 1

Author(s):

John Pollitt

Keyword(s):

Index Case ◽

Late Onset ◽

Depressive Illness ◽

Precipitating Factors ◽

Single Episode ◽

Depressed Patients ◽

Manic Depressive ◽

Close Relatives ◽

Genetically Determined ◽

The Relationship

Scientific studies of the families of depressed patients have shown that the risk of development of similar illnesses for close relatives is greater when the illness of the index case began relatively early in life than when it began later. These studies have included both manic-depressive and single episode endogeneous depressions, and no account has been taken of the mode of precipitation of the illnesses. It has been postulated that (a) the penetrance of the gene may be lower in those families with late onset of depression, and (b) that depressive illness may be of diverse aetiology, so that genetically determined forms appear earlier in life and those which are not genetically determined occur later (Hopkinson and Ley 1969).

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