Book ReviewNuclear Diagnostic Imaging: Practical clinical applications Nuclear Techniques in Diagnostic Medicine

1987 ◽  
Vol 317 (13) ◽  
pp. 843-844
Author(s):  
James W. Fletcher
Keyword(s):  
Diagnostic Imaging ◽  
Clinical Applications ◽  
Nuclear Techniques ◽  
Diagnostic Medicine

Peptide-based Radiopharmaceuticals at a Glance

2021 ◽  
Author(s):  
Sajad Kaihani ◽  
Nourollah Sadeghzadeh
Keyword(s):  
Diagnostic Imaging ◽  
Vasoactive Intestinal Peptide ◽  
Chelating Agents ◽  
Bioactive Peptides ◽  
Clinical Applications ◽  
Human Tumors ◽  
Peptide Receptors ◽  
Wide Range

Because of peptide receptors overexpression in many of the human tumors, the peptide receptors would be an attractive target for diagnostic imaging and radiotherapy. Accordingly, peptide-based radiopharmaceuticals were designed to bind to these receptors and be able to pursue their goals. Wide range of bifunctional chelating agents (BFCA) can be used for the convenient radiolabeling of bioactive peptides with different radionuclides. These advantages have led to producing a wide variety of peptide radiopharmaceuticals. A number of these peptides, such as bombesin, somatostatin, neurotensin, cholecystokinin/gastrin and vasoactive intestinal peptide have been able to have clinical applications in nuclear oncology. In this article we have tried to have an overview of peptide-based radiopharmaceuticals.

scholarly journals Clinical applications of the venous excess ultrasound (VExUS) score: conceptual review and case series

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Philippe Rola ◽  
Francisco Miralles-Aguiar ◽  
Eduardo Argaiz ◽  
William Beaubien-Souligny ◽  
Korbin Haycock ◽  
...  
Keyword(s):  
Diagnostic Imaging ◽  
Physical Examination ◽  
Point Of Care ◽  
Case Series ◽  
Clinical Applications ◽  
Right Ventricular Failure ◽  
Point Of Care Ultrasound ◽  
Clinical Tool ◽  
Ventricular Failure ◽  
Ultrasound Score

AbstractThe importance of functional right ventricular failure and resultant splanchnic venous congestion has long been under-appreciated and is difficult to assess by traditional physical examination and standard diagnostic imaging. The recent development of the venous excess ultrasound score (VExUS) and growth of point-of-care ultrasound in the last decade has made for a potentially very useful clinical tool. We review the rationale for its use in several pathologies and illustrate with several clinical cases where VExUS was pivotal in clinical management.

Contrast echocardiography: current status and future directions

Heart ◽  
2020 ◽  
Vol 107 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Jonathan R Lindner
Keyword(s):  
Diagnostic Imaging ◽  
Diagnostic Performance ◽  
Contrast Echocardiography ◽  
Left Ventricular ◽  
Clinical Applications ◽  
Current Status ◽  
Intravenous Route ◽  
Future Directions ◽  
Incremental Information ◽  
Contrast Ultrasound

Contrast echocardiography is a family of ultrasound-based procedures, whereby acoustic enhancing agents, usually microbubbles, are administered by intravenous route and detected in order to improve diagnostic performance. This review describes: (1) the agents that have been designed for diagnostic imaging, (2) current clinical applications where either left ventricular opacification or microvascular perfusion imaging with myocardial contrast echocardiography have been demonstrated to provide incremental information to non-contrast echocardiography and (3) future diagnostic and therapeutic applications of contrast ultrasound that rely on unique compositional design of ultrasound-enhancing agents.

scholarly journals Current and emerging clinical applications of PSMA-PET diagnostic imaging for prostate cancer

2021 ◽  
pp. jnumed.120.257238
Author(s):  
Andrea Farolfi ◽  
Letizia Calderoni ◽  
Francesco Mattana ◽  
Riccardo Mei ◽  
Silvi Telo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Imaging ◽  
Clinical Applications ◽  
Psma Pet

Specimen Preparation for Clinical Applications of X-Ray Microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 328-329
Author(s):  
J.D. Shelburne ◽  
G.M. Roomans
Keyword(s):  
Carbon Coating ◽  
Clinical Applications ◽  
Point Of View ◽  
Practical Significance ◽  
Sweat Test ◽  
Specimen Preparation ◽  
Tissue Preparation ◽  
X Ray ◽  
Gallbladder Stones ◽  
Clinical Problems

Proper preparative procedures are a prerequisite for the validity of the results of x-ray microanalysis of biological tissue. Clinical applications of x-ray microanalysis are often concerned with diagnostic problems and the results may have profound practical significance for the patient. From this point of view it is especially important that specimen preparation for clinical applications is carried out correctly.Some clinical problems require very little tissue preparation. Hair, nails, and kidney and gallbladder stones may be examined and analyzed after carbon coating. High levels of zinc or copper in hair may be indicative of dermatological or systemic diseases. Nail clippings may be analyzed (as an alternative to the more conventional sweat test) to confirm a diagnosis of cystic fibrosis. X-ray microanalysis in combination with scanning electron microscopy has been shown to be the most reliable method for the identification of the components of kidney or gallbladder stones.A quantitatively very important clinical application of x-ray microanalysis is the identification and quantification of asbestos and other exogenous particles in lung.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

Simple teaching aid with clinical applications

1976 ◽  
Vol 40 (2) ◽  
pp. 106-106
Author(s):  
DL Torney ◽  
HD Espinosa
Keyword(s):  
Clinical Applications ◽  
Teaching Aid

Lexical Comprehension in Young Children With Developmental Delays

1994 ◽  
Vol 3 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Theresa A. Kouri
Keyword(s):  
Young Children ◽  
Developmental Delays ◽  
Normal Development ◽  
Clinical Applications ◽  
Group Status ◽  
Novel Object ◽  
Related Information ◽  
Comprehension Skills ◽  
Lexical Items ◽  
Lexical Concepts

Lexical comprehension skills were examined in 20 young children (aged 28–45 months) with developmental delays (DD) and 20 children (aged 19–34 months) with normal development (ND). Each was assigned to either a story-like script condition or a simple ostensive labeling condition in which the names of three novel object and action items were presented over two experimental sessions. During the experimental sessions, receptive knowledge of the lexical items was assessed through a series of target and generalization probes. Results indicated that all children, irrespective of group status, acquired more lexical concepts in the ostensive labeling condition than in the story narrative condition. Overall, both groups acquired more object than action words, although subjects with ND comprehended more action words than subjects with DD. More target than generalization items were also comprehended by both groups. It is concluded that young children’s comprehension of new lexical concepts is facilitated more by a context in which simple ostensive labels accompany the presentation of specific objects and actions than one in which objects and actions are surrounded by thematic and event-related information. Various clinical applications focusing on the lexical training of young children with DD are discussed.

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