By using the commercial CFD software Fluent6.3, the three-phase (water, air, vapour) flow field with natural cavitation was established. The UDF(User Defined Function) was used to resolve and control the missiles movement. It realized the numerical calculation of unsteady high-speed water-entry flow field, which consider natural cavitation as well as the missiles multiple degree of free movement. In this paper, the missile high-speed water-entry flow field with different attitude angle were simulated and analyzed, and the influence of the attitude angle on the flow field were gained.