Design and optimization of the diamagnetic lateral force calibration method

2018 ◽  
Vol 89 (11) ◽  
pp. 113704 ◽  
Author(s):  
Cangyu Qu ◽  
Bingtong Liu ◽  
Ming Ma ◽  
Quanshui Zheng
2006 ◽  
Vol 326-328 ◽  
pp. 1-4
Author(s):  
Kyung Suk Kim

Two different types of experimental methods have beeen developed for measuring lateral interaction forces between two solid surfaces for nano- and micro-meter scale contacts. One is the type of direct measurement methods which typically utilize AFM instrumentations. In the direct lateral force measurements some size-scale effects are commonly observed due to the effects of adhesion and surface roughness. A recent development of a fine AFM lateral force calibration method, a diamagnetic lateral force calibrator, has made it possible to study such size-scale effects systematically. The other type is the field projection method which requires a high resolution measurement of a deformation field near the edge of a contact. For such measurements a comprehensive map of deformation measurement techniques is introduced in a domain of spatial and strain resolutions. This technique provides a way of assessing the non-uniform distribution of the surface interaction forces for nano and micro-meter scale contacts.


2015 ◽  
Vol 6 ◽  
pp. 1164-1175 ◽  
Author(s):  
Andrzej J Kulik ◽  
Małgorzata Lekka ◽  
Kyumin Lee ◽  
Grazyna Pyka-Fościak ◽  
Wieslaw Nowak

The first experiment showing the effects of specific interaction forces using lateral force microscopy (LFM) was demonstrated for lectin–carbohydrate interactions some years ago. Such measurements are possible under the assumption that specific forces strongly dominate over the non-specific ones. However, obtaining quantitative results requires the complex and tedious calibration of a torsional force. Here, a new and relatively simple method for the calibration of the torsional force is presented. The proposed calibration method is validated through the measurement of the interaction forces between human fibronectin and its monoclonal antibody. The results obtained using LFM and AFM-based classical force spectroscopies showed similar unbinding forces recorded at similar loading rates. Our studies verify that the proposed lateral force calibration method can be applied to study single molecule interactions.


2020 ◽  
Vol 68 (4) ◽  
Author(s):  
Arnab Bhattacharjee ◽  
Nikolay T. Garabedian ◽  
Christopher L. Evans ◽  
David L. Burris

2013 ◽  
Vol 24 ◽  
pp. 1360031
Author(s):  
CHUNG-LIN WU ◽  
CHING-FEN TUAN

This paper presents an approach for calibrating the force transducer on the nano universal testing machine using milligram weights. Previous research on force calibration of such a system focused on the range from 10 mN to 200 mN, ignoring forces below 10 mN. The main purpose of this study is to analyze and calculate the uncertainty of force measurements within the range from 0.2 mN to 10 mN. The ABA calibration method in accordance with OIML R111-1 is adopted to determine the uncertainty in force measurement. The results indicate that the maximum relative uncertainty of force measurement is 7.0 × 10−3 with a 95% confidence level. The investigation can be used as the basis for evaluating measurement uncertainty of the system in small force range.


Author(s):  
Hiroaki Amakawa ◽  
Kenji Fukuzawa ◽  
Mitsuhiro Shikida ◽  
Hedong Zhang ◽  
Shitaro Itoh

Conventional friction force microscopes (FFMs) had the disadvantage of low force sensitivity due to mechanical interference between torsion caused by friction force and deflection by normal force. In order to overcome disadvantage, we developed a dual-axis micro-mechanical probe, which measures the lateral force by the double cantilever and the vertical force by the torsion beam. However, the calibration method of the lateral force has not been established. In this study, we present a new calibration method using a step-structure.


2017 ◽  
Vol 182 ◽  
pp. 1-9 ◽  
Author(s):  
Cezary Dziekoński ◽  
Wojciech Dera ◽  
Dariusz M. Jarząbek

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