Vaccine safety and efficacy: A literature review

2021 ◽  
Author(s):  
Zijun He ◽  
Mengshu He ◽  
Emily Yuan
Keyword(s):  
Literature Review ◽  
Vaccine Safety ◽  
Safety And Efficacy

Vaccinations in Infants Born Preterm: An Update

2020 ◽  
Vol 16 (2) ◽  
pp. 148-155
Author(s):  
Areti Aphrodite Sioriki ◽  
Despoina Gkentzi ◽  
Evangelia Papadimitriou ◽  
Gabriel Dimitriou ◽  
Ageliki Karatza
Keyword(s):  
Preterm Infants ◽  
Vaccine Safety ◽  
Full Term ◽  
Morbidity And Mortality ◽  
Term Infants ◽  
Safety And Efficacy ◽  
Vaccine Preventable Diseases ◽  
Increased Risk ◽  
Protective Antibodies

Infants born prematurely (before completion of 37 weeks of gestation) are at increased risk of morbidity and mortality due to vaccine preventable diseases, mostly because of their immunological immaturity and failure of transfer of maternal protective antibodies. Despite their great need of being vaccinated, concerns on vaccine safety and efficacy, constitute the main reasons for which vaccinations are often delayed in this group. In this review we summarize the latest evidence on vaccine safety, efficacy and immunogenicity in preterm infants which is similar to full-term infants. Therefore there is no reason for delaying vaccination in this population.

Safety and efficacy of intrathecal ziconotide: a literature review

2012 ◽  
Vol 13 (4) ◽  
pp. S6
Author(s):  
S. Goel ◽  
M. Grabois ◽  
S. Aranke
Keyword(s):  
Literature Review ◽  
Safety And Efficacy

Evaluation of Shigella vaccine safety and efficacy in an intranasally challenged mouse model

Vaccine ◽  
1992 ◽  
Vol 10 (4) ◽  
pp. 267
Author(s):  
Thomas Larry Hale ◽  
Corey P. Mallett ◽  
Lillian Van De Verg ◽  
Hugh H. Collins
Keyword(s):  
Mouse Model ◽  
Vaccine Safety ◽  
Safety And Efficacy

Oral application of live oocyst-based coccidiosis vaccine: safety and efficacy

1998 ◽  
Vol 47 ◽  
pp. 271
Author(s):  
A. Vermeulen ◽  
T. Schetters ◽  
H. Janssen ◽  
H. Peek ◽  
W. Braunius
Keyword(s):  
Vaccine Safety ◽  
Safety And Efficacy ◽  
Oral Application

scholarly journals Prevalence and Determinants of Vaccine Hesitancy in Aseer Region, Saudi Arabia

2021 ◽  
Author(s):  
Youssef Ali Alqahtani ◽  
Khalid Hussein Almutairi ◽  
Yahya Mohammed Alqahtani ◽  
Ahmed Hussein Almutlaq ◽  
Anas Ali Asiri
Keyword(s):  
Saudi Arabia ◽  
Demographic Data ◽  
Herd Immunity ◽  
Vaccine Safety ◽  
Vaccination Schedule ◽  
Vaccine Hesitancy ◽  
Cross Sectional ◽  
Safety And Efficacy ◽  
Childhood Vaccines ◽  
Child Vaccination

Objectives: Vaccination is the provision of a vaccine to initiate immunity trough stimulating immune system to develop protection from a certain disease. When a sufficiently large proportion of a population has been vaccinated, herd immunity initiated. The effectiveness of vaccination has been widely studied and verified. Although the harsh vaccine safety systems, some parents remain minded regarding the safety of the childhood vaccines and immunization schedule. These hesitations pushed some parents to not allow their children to receive some or all the scheduled vaccines.  The aim of the study is to assess the general population awareness regarding vaccines and to detect prevalence of vaccine hesitancy in Aseer region, southern of Saudi Arabia. Methods: A descriptive cross-sectional approach was used targeting all parents in Aseer region. Data were collected using structured questionnaire which developed by the researchers after intensive literature review and expert’s consultation. The questionnaire data included parents’ socio-demographic data, parents’ awareness regarding child vaccines safety and efficacy, parents’ attitude and adherence to children vaccination and hesitancy towards vaccines. Results: The survey included 796 participants whose ages ranged from 18 to 55 years old. Two thirds (63.4%) of the participants were females. Regarding vaccination adherence and hesitancy among participants, more than three quarters were completely adherent to the child vaccination schedule and only 3.9% were non adherent. As for participants awareness regarding child vaccination safety and efficacy, 89.3% of the respondents agreed on that vaccination keep child healthy, 84.2% reported that child vaccine is safe and effective, 83.4% said that all Saudi scheduled vaccines are effective. Conclusion: In conclusion, the study revealed that vaccine hesitancy among participants was not low and should be considered irrespective of their high awareness level. The recorded antivaccine action was mostly related to vaccines safety not efficacy. Keywords: Vaccine hesitancy, antivaccine movement, parents, awareness, adherence

scholarly journals Safety and efficacy of pemetrexed in gynecologic cancers: A systematic literature review

2013 ◽  
Vol 02 (02) ◽  
pp. 19-32 ◽  
Author(s):  
David Scott Miller ◽  
Datchen Fritz Tai ◽  
Coleman Obasaju ◽  
Ignace Vergote
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Gynecologic Cancers ◽  
Safety And Efficacy

Persuasive messaging for human papillomavirus vaccination by adolescent providers in a five-country multi-site study

2019 ◽  
Vol 29 (2) ◽  
pp. 250-256
Author(s):  
Janvier Rwamwejo ◽  
Silvina Ramos ◽  
Karen Morgan ◽  
Karin Richter ◽  
Chan Joo Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
National Policy ◽  
Vaccine Safety ◽  
Cervical Cancer Prevention ◽  
Decision Makers ◽  
Patient Acceptance ◽  
Human Papillomavirus Vaccination ◽  
Safety And Efficacy ◽  
Prevention Messages

ObjectiveStrong persuasive messaging by providers is a key predictor for patient acceptance of prophylactic human papillomavirus vaccination. We aimed to determine optimal messaging to promote human papillomavirus adolescent vaccination across different geographical sites.MethodsAdolescent providers (n = 151) from Argentina, Malaysia, South Africa, South Korea, and Spain were surveyed on messages, family decision makers, and sources of communication to best motivate parents to vaccinate their adolescent daughters overall, and against human papillomavirus. Multivariate logistic regression assessed the likelihood of recommending messages specifically targeted at cervical cancer with providers’ characteristics: gender, medical specialization, and previous administration of human papillomavirus vaccination.ResultsMothers were considered the most important human papillomavirus vaccination decision makers for their daughters (range 93%–100%). Television was cited as the best source of information on human papillomavirus vaccination in surveyed countries (range 56.5%–87.1%), except Spain where one-on-one discussions were most common (73.3%). Prevention messages were considered the most likely to motivate parents to vaccinate their daughters overall, and against human papillomavirus, in all five countries (range 30.8%–55.9%). Optimal messages emphasized cervical cancer prevention, and included strong provider recommendation to vaccinate, vaccine safety and efficacy, timely vaccination, and national policy for human papillomavirus vaccination. Pediatricians and obstetricians/gynecologists were more likely to cite that the best prevention messages should focus on cervical cancer (OR: 4.2, 95% CI: 1.17 to 15.02 vs other medical specialists).ConclusionsProvider communication messages that would motivate parents to vaccinate against human papillomavirus were based on strong recommendation emphasizing prevention of cervical cancer. To frame convincing messages to increase vaccination uptake, adolescent providers should receive updated training on human papillomavirus and associated cancers, while clearly addressing human papillomavirus vaccination safety and efficacy.

COVID 19 and vaccine safety

2021 ◽  
Vol 11 (8) ◽  
pp. 313-321
Author(s):  
Przemysław Raczkiewicz ◽  
Bartłomiej Zaremba ◽  
Natalia Śmiech ◽  
Katarzyna Nowakowska ◽  
Martyna Lewkowicz ◽  
...  
Keyword(s):  
Viral Vectors ◽  
Vaccine Safety ◽  
Therapeutic Agents ◽  
International Expert ◽  
Strong Immune Response ◽  
Over The Counter ◽  
Safety And Efficacy ◽  
First Case ◽  
Production Technologies ◽  
Expert Recommendations

Introduction. COVID-19 disease, caused by SARS-CoV-2 virus, has been recognised as pandemic by WHO since March 11, 2020. It has been estimated that the disease is responsible for the death of 3.11 million people worldwide. Although several therapeutic agents have been evaluated for the treatment of COVID-19 disease, vaccines are considered to be the safest form of protecting patients against COVID-19. The safety of each vaccine is vital to control the pandemic. Due to the fact that vaccines have been launched quite recently and their production technologies are different, the safety of each preparation should be looked into separately. Nucleic acids do not trigger such a strong immune response on their own as viral vectors and that is why mRNA vaccines seem to be the safest types of vaccines. In December 2020, after a year since detecting the first case of by SARS-CoV-2 infection in humans, the first anti-COVID-19 vaccine became available.Objective. The purpose of this review was to present the literature data and the latest recommendations on risks related with COVID-19 vaccines.Method. The latest literature was reviewed based on PubMed and Google Scholar databases, using the following keywords: COVID-19; vaccines; safetyConclusions. Anti-COVID-19 vaccines seem not to cause many adverse events and side effects such as fever, chills, muscle pain, headache and fatigue. These are not serious and subside after taking over-the-counter pain relievers. Currently, there are no information on safety and efficacy of vaccines in pregnant and breast-feeding women, international expert recommendations leave the decision about vaccination with a woman, who should previously consult the benefits and risks involved with her doctor.

Individualised caries prevention with fluoride in children and adolescents – recommendations of Polish experts

2019 ◽  
Vol 24 (2) ◽  
Author(s):  
Urszula Kaczmarek ◽  
Teresa Jackowska ◽  
Maria Mielnik-Błaszczak ◽  
Anna Jurczak ◽  
Dorota Olczak-Kowalczyk
Keyword(s):  
Dental Caries ◽  
Literature Review ◽  
Children And Adolescents ◽  
Working Group ◽  
Paediatric Population ◽  
Paediatric Dentistry ◽  
Basic Data ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Current Guidelines

In addition to proper diet, the use of fluoride is the primary and effective method for the prevention of dental caries in primary and permanent dentition. Knowledge and compliance with the current guidelines for the use of different strategies and agents containing fluoride compounds is crucial for ensuring safety and efficacy of prevention. A panel of experts in paediatric dentistry and paediatrics was established as part of the working group of the Polish Branch of Alliance for a Cavity-Free Future (ACFF) to update the position on individual fluoride prevention in children and adolescents in Poland. We conducted a literature review on the knowledge of fluoride prevention, its use in the paediatric population in Poland, efficacy and safety of fluoride-containing preventive agents, as well as recommendations on fluoride prophylaxis issued by academic organisations and societies in different countries worldwide. The first version of the document was discussed and accepted by the panel of experts on paediatrics and paediatric dentistry on the 4th of April 2019. Update was scheduled for not later than 5 years after publication. This document includes basic data on the knowledge of fluoride prevention in parents, children and adolescents, the anticariogenic mechanism of fluoride, the safety and efficacy of different methods for individual fluoride prophylaxis, and the principles for its use depending on age and the risk of caries.

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