The structure and function of oestrogens. III. 3,17β-Dihydroxy-6-oxaoestra-1,3,5(10),8(9)-tetraen-7-one and related steroidal coumarins
Keyword(s):
A Pechmann condensation of resorcinol, or resorcinol monomethyl ether with ethyl t-7a-methyl- 1,5-dioxo-r-3a,4,5,6,7,7a-hexahydroindan-c-4-carboxylate (10b) gave 3-hydroxy-6-oxaoestra- 1,3,5(10),8(9)-tetraene-7,17-dione (3a), or the corresponding 3-methoxy compound (3b), respectively. Reduction of 3-hydroxy-6-oxaoestra-1,3,5(10),8(9)-tetraene-7,17-dione (3a) with sodium borohydride gave 3,17β-dihydroxy-6-oxaoestra-1,3,5(10),8(9)-tetraen-7-one (11). Compounds (3a) and (11) were tested for oestrogenic activity.
1988 ◽
Vol 46
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pp. 26-27
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1992 ◽
Vol 50
(1)
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pp. 506-507
1975 ◽
Vol 33
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pp. 640-641
2011 ◽
Vol 21
(3)
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pp. 112-117
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1997 ◽
Vol 103
(1)
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pp. 19
1973 ◽
Vol 44
(1-21012)
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pp. 1-1
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1993 ◽
Vol 3
(1)
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pp. 13-40
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2008 ◽
Vol 7
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pp. 125-125