Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study

2016 ◽  
Vol 28 (5) ◽  
pp. 648 ◽  
Author(s):  
Li-Xin Tang ◽  
Dong-Juan Yuan ◽  
Qi-Ling Wang ◽  
Fang Jiang ◽  
Jian Guo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Cell Structure ◽  
Case Control ◽  
Omega 3 ◽  
Infertile Men ◽  
Omega 6 ◽  
Control Study

Varicocele is commonly associated with male infertility because it impairs normal sperm morphology and activity. Polyunsaturated fatty acids (PUFA) are important determinants of sperm cell structure and function, but their relationship with varicocele remains unclear. The aim of the present study was to investigate the PUFA composition in spermatozoa of infertile men with varicocele and to evaluate the potential relationship between PUFA and varicocele. This case control study recruited 92 infertile men with varicocele, 99 infertile men without varicocele and 95 fertile male control subjects. Semen morphology and activity parameters were assessed and seminal plasma 8-hydroxy-2-deoxyguanosine (8-OHdG) content was determined by ELISA. Sperm concentrations of omega-3 and omega-6 fatty acids were measured by gas chromatography. Infertile men with varicocele had lower concentrations of omega-3 PUFA, higher omega-6 : omega-3 PUFA ratios and greater oxidative DNA damage in spermatozoa compared with infertile men without varicocele and normal subjects. The degree of varicocele and DNA damage was associated with decreased omega-3 PUFA concentrations and semen quality in infertile men with varicocele. The findings suggest that omega-3 PUFA deficiency could be implicated in varicocele-associated infertility, and highlight the need for intervention trials to test the usefulness of omega-3 supplementation in reducing sperm abnormalities in infertile men with varicocele.

Evaluation of Angiogenic growth mediators and Oxidative DNA damage marker in serum and placentas of women with preeclampsia: a case-control study in Ghana

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e107
Author(s):  
Enoch Anto ◽  
Peter Roberts ◽  
David Coall ◽  
Cornelius Turpin ◽  
Osei-Owusu Afriyie ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Damage Marker ◽  
Control Study

A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Effect of Tumor Removal

2015 ◽  
Vol 87 ◽  
pp. S70
Author(s):  
Uraiwan Panich ◽  
Lapatsanant Chaisiriwong Chaisiriwong ◽  
Rungsima Wanitphakdeedecha ◽  
Panitta Sitthinamsuwan ◽  
Somruedee Chatsiricharoenkul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Basal Cell Carcinoma ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Case Control Study ◽  
Antioxidant Defense System ◽  
Case Control ◽  
Defense System ◽  
Tumor Removal ◽  
Control Study

Abstract 15888: N-3 Polyunsaturated Fatty Acids in Erythrocyte Membranes and Risk of Sudden Cardiac Death in Primary and Secondary Prevention

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Stephanie E Chiuve ◽  
Nancy R Cook ◽  
Martin J Vandenburgh ◽  
Eric B Rimm ◽  
JoAnn E Manson ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Lower Risk ◽  
Case Control Study ◽  
Case Control ◽  
Omega 3 ◽  
Nested Case Control ◽  
Control Study ◽  
Long Chain

Introduction: Long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-arrhythmic effects in experimental studies and blood levels of EPA + DHA, an objective marker of intake, have been associated with lower risk of sudden cardiac death (SCD) in healthy populations. However, data from observational studies and clinical trials of n-3 PUFAs in secondary prevention have been mixed. Methods: We conducted a nested, case-control study among individuals from 6 prospective cohort studies. RBC levels of α-linolenic acid (ALA), EPA, docosapentaenoic acid (DPA), and DHA were measured in 442 cases of SCD and 852 controls matched on age, sex, race, smoking status, fasting status and prevalent and incident CVD using risk-set sampling. The Omega-3 Index was estimated as EPA + DHA. Multivariable conditional logistic regression was used to estimate the relative risk (RR) separately in each cohort. The RRs were combined using random effect meta-analyses and stratified by presence of absence of known CVD prior to SCD. Results: In this population, the mean age was 64 years, 51% were women and 41% had prior CVD. Higher EPA and DHA levels, as summarized by the Omega-3 Index, were associated with lower risk of SCD in the entire population (Table). Compared to the lowest quintile, the RR in the highest quintile of the Omega-3 Index was 0.40 (95%CI, 0.21-0.77; P, trend= 0.04). When stratified by history of prior CVD, this association was restricted to individuals without prior CVD (Table, P, trend = 0.03). Neither DPA nor ALA was associated with risk of SCD in those with or without CVD. Conclusions: In this prospective nested, case-control study, the inverse association between long-chain n-3 PUFAs and SCD was limited to individuals without prior CVD. These data suggest that the utility of n-3 PUFAs as markers of SCD and/or as preventative dietary supplements may be greater in a primary prevention population.

scholarly journals Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

2016 ◽  
Vol 76 (1) ◽  
pp. 147-152 ◽  
Author(s):  
Ryan W Gan ◽  
M Kristen Demoruelle ◽  
Kevin D Deane ◽  
Michael H Weisman ◽  
Jane H Buckner ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Case Control Study ◽  
Shared Epitope ◽  
Case Control ◽  
Lower Prevalence ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Supplement Use ◽  
Control Study

ObjectivesPreviously, we found that omega-3 fatty acids (n-3 FAs) were inversely associated with anti-cyclic citrullinated peptide (anti-CCP) positivity in participants at risk for future rheumatoid arthritis (RA). We investigated whether n-3 FAs were also associated with rheumatoid factor (RF) positivity and whether these associations were modified by shared epitope (SE) positivity.MethodsThe Studies of the Etiology of RA (SERA) cohort includes RA-free participants who are at increased risk for RA. We conducted a nested case–control study (n=136) to determine the association between RF and anti-CCP2 positivity and n-3 FA percentage in erythrocyte membranes (n-3 FA% in red blood cells (RBCs)). Additionally, in the baseline visit of the SERA cohort (n=2166), we evaluated the association between reported n-3 FA supplement use and prevalence of RF and anti-CCP2. We assessed SE positivity as an effect modifier.ResultsIn the case–control study, increasing n-3 FA% in RBCs was inversely associated with RF positivity in SE-positive participants (OR 0.27, 95% CI 0.10 to 0.79), but not SE-negative participants. Similar associations were seen with anti-CCP positivity in SE-positive participants (OR 0.42, 95% CI 0.20 to 0.89), but not SE-negative participants. In the SERA cohort at baseline, n-3 FA supplement use was associated with a lower prevalence of RF positivity in SE-positive participants (OR 0.32, 95% CI 0.12 to 0.82), but not SE-negative participants; similar but non-significant trends were observed with anti-CCP2.ConclusionsThe potential protective effect of n-3 FAs on RA-related autoimmunity may be most pronounced in those who exhibit HLA class II genetic susceptibility to RA.

scholarly journals Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case–control study

2012 ◽  
Vol 52 (3) ◽  
pp. 1251-1260 ◽  
Author(s):  
Hannah Arem ◽  
Marian L. Neuhouser ◽  
Melinda L. Irwin ◽  
Brenda Cartmel ◽  
Lingeng Lu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Omega 3 ◽  
Endometrial Cancer Risk ◽  
Omega 6 ◽  
Control Study

Recruitment for a Pilot Case Control Study of Oxidative DNA Damage and Breast Cancer Risk

2000 ◽  
Vol 23 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Michael S. Simon ◽  
Lance K. Heilbrun ◽  
Deanna Stephens ◽  
Samir Lababidi ◽  
Zora Djuric
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case–control study

JGH Open ◽  
2021 ◽  
Author(s):  
Hamid Reza Fazli ◽  
Ashraf Mohamadkhani ◽  
Hamed Reza Godarzi ◽  
Akram Pourshams ◽  
Mojtaba Jafari Nia
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
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