scholarly journals Lead Induced Oxidative DNA Damage among the Occupationally Exposed Workers: A Case-Control Study

2020 ◽  
Author(s):  
Jyoti Batra ◽  
Ajit Thakur ◽  
Deepak Juyal ◽  
Shrawan Kumar Meena
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Control Study

Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study

2016 ◽  
Vol 28 (5) ◽  
pp. 648 ◽  
Author(s):  
Li-Xin Tang ◽  
Dong-Juan Yuan ◽  
Qi-Ling Wang ◽  
Fang Jiang ◽  
Jian Guo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Cell Structure ◽  
Case Control ◽  
Omega 3 ◽  
Infertile Men ◽  
Omega 6 ◽  
Control Study

Varicocele is commonly associated with male infertility because it impairs normal sperm morphology and activity. Polyunsaturated fatty acids (PUFA) are important determinants of sperm cell structure and function, but their relationship with varicocele remains unclear. The aim of the present study was to investigate the PUFA composition in spermatozoa of infertile men with varicocele and to evaluate the potential relationship between PUFA and varicocele. This case control study recruited 92 infertile men with varicocele, 99 infertile men without varicocele and 95 fertile male control subjects. Semen morphology and activity parameters were assessed and seminal plasma 8-hydroxy-2-deoxyguanosine (8-OHdG) content was determined by ELISA. Sperm concentrations of omega-3 and omega-6 fatty acids were measured by gas chromatography. Infertile men with varicocele had lower concentrations of omega-3 PUFA, higher omega-6 : omega-3 PUFA ratios and greater oxidative DNA damage in spermatozoa compared with infertile men without varicocele and normal subjects. The degree of varicocele and DNA damage was associated with decreased omega-3 PUFA concentrations and semen quality in infertile men with varicocele. The findings suggest that omega-3 PUFA deficiency could be implicated in varicocele-associated infertility, and highlight the need for intervention trials to test the usefulness of omega-3 supplementation in reducing sperm abnormalities in infertile men with varicocele.

Evaluation of Angiogenic growth mediators and Oxidative DNA damage marker in serum and placentas of women with preeclampsia: a case-control study in Ghana

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e107
Author(s):  
Enoch Anto ◽  
Peter Roberts ◽  
David Coall ◽  
Cornelius Turpin ◽  
Osei-Owusu Afriyie ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Damage Marker ◽  
Control Study

A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Effect of Tumor Removal

2015 ◽  
Vol 87 ◽  
pp. S70
Author(s):  
Uraiwan Panich ◽  
Lapatsanant Chaisiriwong Chaisiriwong ◽  
Rungsima Wanitphakdeedecha ◽  
Panitta Sitthinamsuwan ◽  
Somruedee Chatsiricharoenkul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Basal Cell Carcinoma ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Case Control Study ◽  
Antioxidant Defense System ◽  
Case Control ◽  
Defense System ◽  
Tumor Removal ◽  
Control Study

Recruitment for a Pilot Case Control Study of Oxidative DNA Damage and Breast Cancer Risk

2000 ◽  
Vol 23 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Michael S. Simon ◽  
Lance K. Heilbrun ◽  
Deanna Stephens ◽  
Samir Lababidi ◽  
Zora Djuric
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case–control study

JGH Open ◽  
2021 ◽  
Author(s):  
Hamid Reza Fazli ◽  
Ashraf Mohamadkhani ◽  
Hamed Reza Godarzi ◽  
Akram Pourshams ◽  
Mojtaba Jafari Nia
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Lapatsanant Chaisiriwong ◽  
Rungsima Wanitphakdeedecha ◽  
Panitta Sitthinamsuwan ◽  
Somponnat Sampattavanich ◽  
Somruedee Chatsiricharoenkul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Oxidative Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Antioxidant Defenses ◽  
Plasma Antioxidant ◽  
Control Study

Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). This study illustrated an involvement of oxidative DNA damage and changes in antioxidant defenses in BCC by conducting a case-control study (24 controls and 24 BCC patients) and assessing urinary 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo), plasma antioxidant defenses including catalase (CAT), glutathione peroxidase (GPx), NQO1, and total superoxide dismutase (SOD) activities, and glutathione (GSH) levels before surgery and 1 month after surgery. 8-oxo-dGuo expressions as well as protein and mRNA expressions of DNA repair enzyme hOGG1 and antioxidant defenses (CAT, GCLC, GPx, Nrf2, and MnSOD) in nonneoplastic epidermis of control and BCC tissues were also determined. This study observed induction in urinary 8-oxo-dGuo, increased 8-oxo-dGuo expression, and reduced hOGG1 protein and mRNA in BCC tissues, decreased activities of CAT, GPx, and NQO1, but elevated SOD activities and GSH levels in BCC patients and reduction of all antioxidant proteins and genes studied in BCC tissues. Furthermore, decreased plasma antioxidant activities in BCC patients were restored at 1 month after operation compared with preoperative levels. Herein, we concluded that BCC patients were associated with oxidative DNA damage and depletion of antioxidant defenses and surgical removal of BCC correlated with improved redox status.

Sperm DNA damage and cytokines in varicocele: A case‐control study

Andrologia ◽  
2021 ◽  
Author(s):  
Renata Finelli ◽  
Francesco Pallotti ◽  
Francesco Cargnelutti ◽  
Fabiana Faja ◽  
Tania Carlini ◽  
...  
Keyword(s):  
Dna Damage ◽  
Case Control Study ◽  
Case Control ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Control Study

scholarly journals Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters

Antioxidants ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 12 ◽  
Author(s):  
Iman M. Ahmad ◽  
Maher Y. Abdalla ◽  
Tiffany A. Moore ◽  
Lisa Bartenhagen ◽  
Adam J. Case ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Healthcare Workers ◽  
Immune Modulation ◽  
Oxidative Dna Damage ◽  
Underlying Mechanism ◽  
Increased Risk ◽  
Exposed Workers ◽  
Immune Alterations ◽  
Occupationally Exposed

Studies have shown an increased risk for a variety of cancers, specifically brain cancer, in healthcare workers occupationally exposed to ionizing radiation. Although the mechanisms mediating these phenomena are not fully understood, ionizing radiation-mediated elevated levels of reactive oxygen species (ROS), oxidative DNA damage, and immune modulation are likely involved. A group of 20 radiation exposed workers and 40 sex- and age-matched non-exposed control subjects were recruited for the study. We measured superoxide (O2•−) levels in whole blood of healthcare workers and all other measurements of cytokines, oxidative DNA damage, extracellular superoxide dismutase (EcSOD) activity and reduced/oxidized glutathione ratio (GSH/GSSG) in plasma. Levels of O2•− were significantly higher in radiation exposed workers compared to control. Similarly, a significant increase in the levels of interleukin (IL)-6, IL-1α and macrophage inflammatory protein (MIP)-1α in radiation exposed workers compared to control was observed, while there was no significance difference in the other 27 screened cytokines. A significant positive correlation was found between MIP-1α and O2•− levels with no correlation in either IL-6 or IL-1α. Further, a dose-dependent relationship with significant O2•− production and immune alterations in radiation exposed workers was demonstrated. There was no statistical difference between the groups in terms of oxidative DNA damage, GSH/GSSG levels, or EcSOD activity. Although the biologic significance of cytokines alterations in radiation exposed workers is unclear, further studies are needed for determining the underlying mechanism of their elevation.

scholarly journals A nested case-control study of lung cancer among silica exposed workers in China.

1992 ◽  
Vol 49 (3) ◽  
pp. 167-171 ◽  
Author(s):  
J K McLaughlin ◽  
J Q Chen ◽  
M Dosemeci ◽  
R A Chen ◽  
S H Rexing ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Exposed Workers ◽  
Nested Case Control ◽  
Control Study
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