scholarly journals Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene

2012 ◽  
Vol 287 (24) ◽  
pp. 20652-20663 ◽  
Author(s):  
Dillon W. Leong ◽  
Jasper C. Komen ◽  
Chelsee A. Hewitt ◽  
Estelle Arnaud ◽  
Matthew McKenzie ◽  
...  
Keyword(s):  
Mouse Model ◽  
Complex I ◽  
Nadh Dehydrogenase ◽  
Mitochondrial Complex I ◽  
Deficient Mouse ◽  
Mitochondrial Complex ◽  
S Protein ◽  
Sine Insertion

scholarly journals Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
William W Wheaton ◽  
Samuel E Weinberg ◽  
Robert B Hamanaka ◽  
Saul Soberanes ◽  
Lucas B Sullivan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Progression ◽  
Complex I ◽  
Nadh Dehydrogenase ◽  
Cellular Proliferation ◽  
Human Cancer ◽  
Cellular Respiration ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Human Cancer Cells

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration. Metformin inhibited cellular proliferation in the presence of glucose, but induced cell death upon glucose deprivation, indicating that cancer cells rely exclusively on glycolysis for survival in the presence of metformin. Metformin also reduced hypoxic activation of hypoxia-inducible factor 1 (HIF-1). All of these effects of metformin were reversed when the metformin-resistant Saccharomyces cerevisiae NADH dehydrogenase NDI1 was overexpressed. In vivo, the administration of metformin to mice inhibited the growth of control human cancer cells but not those expressing NDI1. Thus, we have demonstrated that metformin's inhibitory effects on cancer progression are cancer cell autonomous and depend on its ability to inhibit mitochondrial complex I.

scholarly journals Quantitative Mapping of Reversible Mitochondrial Complex I Cysteine Oxidation in a Parkinson Disease Mouse Model

2011 ◽  
Vol 286 (9) ◽  
pp. 7601-7608 ◽  
Author(s):  
Steven R. Danielson ◽  
Jason M. Held ◽  
May Oo ◽  
Rebeccah Riley ◽  
Bradford W. Gibson ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Cysteine Oxidation ◽  
Quantitative Mapping

NAD+ Regeneration Rescues Lifespan But Not Ataxia in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

2019 ◽  
Author(s):  
Greg McElroy ◽  
Colleen Reczek ◽  
Paul Reyfman ◽  
Divaker Mithal ◽  
Craig Horbinski ◽  
...  
Keyword(s):  
Mouse Model ◽  
Complex I ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex

Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I

Nature ◽  
2004 ◽  
Vol 432 (7017) ◽  
pp. 618-622 ◽  
Author(s):  
Ivan Hrdy ◽  
Robert P. Hirt ◽  
Pavel Dolezal ◽  
Lucie Bardonová ◽  
Peter G. Foster ◽  
...  
Keyword(s):  
Complex I ◽  
Nadh Dehydrogenase ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex
Sign in / Sign up

Export Citation Format

Share Document