An architecture for IoT-enabled intelligent process-aware cloud production platform: a case study in a networked cloud clinical laboratory

2019 ◽  
Vol 58 (12) ◽  
pp. 3765-3780 ◽  
Author(s):  
Mohammad Reza Rasouli
Keyword(s):  
Clinical Laboratory ◽  
Production Platform ◽  
Intelligent Process

scholarly journals The “Zero Miles Product” Concept Applied to Biofuel Production: A Case Study

Energies ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 565
Author(s):  
Nikolaj Kaae Kirk ◽  
Clara Navarrete ◽  
Jakob Ellegaard Juhl ◽  
José Luis Martínez ◽  
Alessandra Procentese
Keyword(s):  
Sugar Content ◽  
Point Of View ◽  
Biofuel Production ◽  
Transport Costs ◽  
Economic Point ◽  
Product Concept ◽  
Energy Demands ◽  
Production Platform ◽  
High Sugar Content

To make biofuel production feasible from an economic point of view, several studies have investigated the main associated bottlenecks of the whole production process through approaches such as the “cradle to grave” approach or the Life Cycle Assessment (LCA) analysis, being the main constrains the feedstock collection and transport. Whilst several feedstocks are interesting because of their high sugar content, very few of them are available all year around and moreover do not require high transportation’ costs. This work aims to investigate if the “zero miles” concept could bring advantages to biofuel production by decreasing all the associated transport costs on a locally established production platform. In particular, a specific case study applied to the Technical University of Denmark (DTU) campus is used as example to investigate the advantages and feasibility of using the spent coffee grounds generated at the main cafeteria for the production of bioethanol on site, which can be subsequently used to (partially) cover the campus’ energy demands.

scholarly journals NON-SPECIFIC ULCERATIVE COLITIS AND COVID-19, A CASE STUDY

2021 ◽  
Vol 5 (1) ◽  
pp. 89-92
Author(s):  
Z. P. Lemeshevskaya ◽  
◽  
M. V. Pavlukevich ◽  
N. I. Procopchik ◽  
◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Case ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Medical Documentation ◽  
Atypical Form ◽  
History Of ◽  
Hematoxylin And Eosin ◽  
Somatic Diseases

Background. COVID-19 infection keeps changing our understanding of its clinical course when associated with various somatic diseases. Objective. To present a clinical case of a patient with non-specific ulcerative colitis (NUC) and COVID-19 infection. Material and methods: medical documentation, general clinical, laboratory and instrumental data as well as histological examination of bioptates stained with hematoxylin and eosin that were obtained during colonoscopy. Results. The article presents a case history of a patient with manifestations of severe total NUC developed in association with the subclinical form of COVID-19 infection, the former being the cause of death in concomitant pathology. Conclusions. This clinical case describes a variant of an unfavorable outcome of NUC, one of the reasons for the manifestation of which was the atypical form of COVID-19 infection, which became a trigger for an autoimmune inflammatory process in the intestine. The accumulation of new knowledge about the features of the pathogenesis and manifestations of both pathologies will make it possible to improve the effectiveness of treatment and predict the course and outcomes of combined pathology.

scholarly journals ELECTRONIC MEDICAL RECORD ALGORITHM TO IDENTIFY UNDIAGNOSED (PRE)DIABETES: A CASE STUDY FROM HAWAIʻI

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S934-S934
Author(s):  
David Stupplebeen ◽  
Tetine L Sentell ◽  
Lance Ching ◽  
Blythe Nett ◽  
Hermina Taylor ◽  
...  
Keyword(s):  
Older Adults ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Clinical Laboratory ◽  
Older Men ◽  
State Health ◽  
Missed Opportunities ◽  
The Past ◽  
Department Of Health

Abstract An estimated one-quarter of United States’ older adults (≥65 years) have diabetes (DM) while half have prediabetes (PreDM). Timely diagnosis can prevent disease progression, but significant proportions of PreDM/DM are undiagnosed. Among Hawai‘i adults, one-third of diabetes and two-thirds of prediabetes cases are undiagnosed; rates for older adults are unknown. Algorithms integrated into Electronic Medical Records (EMR) may improve care by identifying probable undiagnosed cases in patient panels using clinical/laboratory measures. We assessed one algorithm developed by the Hawai‘i Department of Health that identified individuals overdue for screening or with Pre/DM using the records of 20,362 adult patients (51.33% were >65) from a major state health system. 6,371 (31.3%) patients were excluded from analysis; they had no HbA1c screening in the past year or were overdue for screening (70%) based on standard guidelines. Of the remaining 13,991 patients, 7317 were older adults; 6130 (84%) had a PreDM (50.6%) or DM (33.2%) HbA1c value; the rest were controlled or false-positive. Of those older adults with probable PreDM/DM, 38.6% were undiagnosed. Adults >65 were significantly more likely to be flagged with undiagnosed PreDM compared to their younger counterparts (58 versus 54%, p<.001). Notably, 61% of older men flagged with PreDM were undiagnosed. Of the 5,737 patients identified with DM, 22% of those 65 were undiagnosed. Given the recognized high burden of diabetes among older adults, results indicate substantial missed opportunities for the prevention and early treatment of this condition as identified by an EMR algorithm.

High Performance BLAST Over the Grid

2011 ◽  
pp. 121-148 ◽  
Author(s):  
Vincent Breton ◽  
Eddy Caron ◽  
Frederic Desprez ◽  
Gael Le Mahec
Keyword(s):  
Data Management ◽  
High Performance ◽  
Large Scale ◽  
Proof Of Concept ◽  
Experimental Platform ◽  
Complex Problems ◽  
Production Platform ◽  
And Storage

As grids become more and more attractive for solving complex problems with high computational and storage requirements, bioinformatics starts to be ported on large scale platforms. The BLAST kernel, one of the main cornerstone of high performance genomics, was one the first application ported on such platform. However, if a simple parallelization was enough for the first proof of concept, its use in production platform needed more optimized algorithms. In this chapter, we review existing parallelization and “gridification” approaches as well as related issues such as data management and replication, and a case study using the DIET middleware over the Grid’5000 experimental platform.

scholarly journals Clinical laboratory automation: a case study

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Claudia Archetti ◽  
Alessandro Montanelli ◽  
Dario Finazzi ◽  
Luigi Caimi ◽  
Emirena Garrafa
Keyword(s):  
Teaching Hospital ◽  
Clinical Laboratory ◽  
Indirect Costs ◽  
Turnaround Time ◽  
Laboratory Automation ◽  
Direct And Indirect Costs ◽  
Academic Teaching ◽  
The North ◽  
Academic Teaching Hospital

<em>Background</em>. This paper presents a case study of an automated clinical laboratory in a large urban academic teaching hospital in the North of Italy, the Spedali Civili in Brescia, where four laboratories were merged in a unique laboratory through the introduction of laboratory automation. <br /><em>Materials and Methods</em>. The analysis compares the preautomation situation and the new setting from a cost perspective, by considering direct and indirect costs. It also presents an analysis of the turnaround time (TAT). The study considers equipment, staff and indirect costs. <br /><em>Results</em>. The introduction of automation led to a slight increase in equipment costs which is highly compensated by a remarkable decrease in staff costs. Consequently, total costs decreased by 12.55%. The analysis of the TAT shows an improvement of nonemergency exams while emergency exams are still validated within the maximum time imposed by the hospital. <br /><em>Conclusions</em>. The strategy adopted by the management, which was based on re-using the available equipment and staff when merging the pre-existing laboratories, has reached its goal: introducing automation while minimizing the costs.

The value of battery testing in the clinical laboratory: A PERT network case study

1984 ◽  
Vol 8 (4) ◽  
pp. 239-247
Author(s):  
N. K. Kwak ◽  
John J. Vargo ◽  
Marc J. Schniederjans
Keyword(s):  
Clinical Laboratory

scholarly journals Application of the Department of Health and Human Services proposed waived status requirements for in vitro diagnostic testing devices: case study

1997 ◽  
Vol 43 (9) ◽  
pp. 1610-1617 ◽  
Author(s):  
Sharon S Ehrmeyer ◽  
Ronald H Laessig
Keyword(s):  
Reference Range ◽  
Clinical Laboratory ◽  
Health Care Financing ◽  
Diagnostic Testing ◽  
Test System ◽  
Department Of Health ◽  
In Vitro Diagnostic ◽  
Clinical Laboratory Testing

Abstract The CLIA’88 classified all clinical laboratory testing as waived, moderate, or high complexity. The eight original waived tests were characterized as simple, accurate, error-free, risk-free, and suitable for home use by nonlaboratory professionals. The subjective nature of the classification process was challenged immediately. The Clinical Laboratory Improvement Advisory Committee asked the CDC and the Health Care Financing Administration to develop objective criteria that included assessment of performance by field-test and in-house data. We examined the efficacy of the CDC protocol with empirical data from the HemoCue B-Hemoglobin Test System® submission, to assess operator competency, intra-/interoperator and between-site imprecision, and accuracy. Non-laboratory-trained operators demonstrated 2–3% imprecision (40–200 g/L). Accuracy studies yielded a slope of 1.01, an intercept of 3.53 g/L, and r of 1.00 (52–230 g/L). Results met the protocol’s Tonks’ criterion for imprecision (less than one-fourth of the reference range).

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