Optimization of Release Conditions of Alzheimer's Drug Donepezil Hydrochloride from Sodium Alginate/Sodium Carboxymethyl Cellulose Blend Microspheres

2014 ◽  
Vol 53 (5) ◽  
pp. 902-917 ◽  
Author(s):  
Emine Bulut ◽  
Oya Şanli
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Sodium Carboxymethyl Cellulose ◽  
Donepezil Hydrochloride

scholarly journals A study of the effects of sodium alginate and sodium carboxymethyl cellulose on the growth of the common duckweed (Lemna minor L.)

2021 ◽  
pp. 82-82
Author(s):  
Bianca Boros ◽  
Nathalie Grau ◽  
Adriana Isvoran ◽  
Adina Datcu ◽  
Nicoleta Ianovici ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Water Solubility ◽  
Lemna Minor ◽  
Sodium Carboxymethyl Cellulose ◽  
Log P ◽  
Growth Inhibitory ◽  
Wide Range ◽  
The Common ◽  
High Doses

Sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC) are two polysaccharides that have a wide range of applications which could lead to accidental pollution of the environment, making the assessment of their potential ecotoxicity imperative. The present study assesses the ALG and CMC effects on the growth response of the common duckweed (Lemna minor L.). The results emphasize that both polysaccharides can be classified as practically nontoxic based on their EC50 values, with ALG having a relatively higher toxicity compared to CMC. It was also observed that high doses of 1, 5 and 10 mg mL-1 of the two polysaccharides produced growth inhibitory effects against common duckweed. The toxicity of biopolymers against common duckweed, measured as EC50 values, seems to be correlated to the hydrophobicity of the monomers building the polymer. The EC50 values increase linearly with the increase of water solubility (log S) values and decrease linearly with the lipophilicity (log P) values.

scholarly journals Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2629
Author(s):  
Yufeng Chen ◽  
Jingchong Peng ◽  
Yueqi Wang ◽  
Daniel Wadhawan ◽  
Lijun Wu ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Electrostatic Interactions ◽  
Storage Stability ◽  
Amorphous State ◽  
Sodium Carboxymethyl Cellulose ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
In Vitro Bioaccessibility

In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.

scholarly journals Chemical characterization, release, and bioactivity of Eucalyptus camaldulensis polyphenols from freeze-dried sodium alginate and sodium carboxymethyl cellulose matrix

2020 ◽  
Vol 4 (4) ◽  
pp. 203-212
Author(s):  
Ozioma Forstinus Nwabor ◽  
Sudarshan Singh ◽  
Dwi Marlina ◽  
Supayang Piyawan Voravuthikunchai
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Food Systems ◽  
Antioxidant Activities ◽  
Chemical Characterization ◽  
Eucalyptus Camaldulensis ◽  
Ethanolic Extract ◽  
Antimicrobial Activities ◽  
Sodium Carboxymethyl Cellulose ◽  
Freeze Dried

Abstract Crude ethanolic extract of Eucalyptus camaldulensis was encapsulated with sodium alginate–sodium carboxymethyl cellulose (CMC) using freeze-drying techniques. The microcapsules were characterized for particle size, morphology, physicochemical parameters, and micromeritics properties. Antioxidant and antimicrobial activities of the microcapsules were also demonstrated. Results revealed an irregular-shaped microparticles with a mean diameter ranging from 6.7 to 26.6 µm. Zeta potential and polydispersity index ranged from −17.01 to 2.23 mV and 0.34 to 0.49, respectively. Percentage yield ranged between 70.4 and 81.5 per cent whereas encapsulation efficiency ranged between 74.2 ± 0.011 and 82.43 ± 0.77 per cent. Swelling index and solubility varied inversely with extract concentration, with a range of 54.4%–84.0% and 18.8%–22.2%, respectively. Antioxidant activities varied directly with the concentration of the extract. Minimum inhibitory and minimum bactericidal concentrations of the microcapsules against Gram-positive foodborne pathogens ranged from 0.19 to 3.12 and 0.19–12.25 mg/ml, respectively. The Higuchi model indicated a time-dependent, delayed, and regulated release of polyphenols at 37°C. The results suggested that alginate–CMC possessed good encapsulant properties that preserved the bioactive extract, thus might be employed for application of natural products in food systems.

scholarly journals Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

Coatings ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 291 ◽  
Author(s):  
Wenting Lan ◽  
Li He ◽  
Yaowen Liu
Keyword(s):  
Composite Film ◽  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Test Method ◽  
Sodium Carboxymethyl Cellulose ◽  
Orthogonal Experimental Design ◽  
Cellulose Solution ◽  
Casting Solution ◽  
Carboxymethyl Cellulose Sodium ◽  
Chitosan Composite

A sodium alginate/chitosan solution was prepared by dissolving sodium alginate, chitosan, and glycerol in an acetic acid solution. This solution was then combined with a sodium carboxymethyl cellulose solution and the mixture was cast onto a glass plate and dried at a constant temperature of 60 °C. Then, a carboxymethyl cellulose/sodium alginate/chitosan composite film was obtained by immersing the film in a solution of a cross-linking agent, CaCl2, and air-drying the resulting material. First, the most advantageous contents of the three precursors in the casting solution were determined by a completely random design test method. Thereafter, a comprehensive orthogonal experimental design was applied to select the optimal mass ratio of the three precursors. The composite film obtained with sodium alginate, sodium carboxymethyl cellulose, and chitosan contents of 1.5%, 0.5%, and 1.5%, respectively, in the casting solution displayed excellent tensile strength, water vapor transmission rate, and elongation after fracture. Moreover, the presence of chitosan successfully inhibited the growth and reproduction of microorganisms. The composite film exhibited antibacterial rates of 95.7% ± 5.4% and 93.4% ± 4.7% against Escherichia coli and Staphylococcus aureus, respectively. Therefore, the composite film is promising for antibacterial food packaging applications.

Nanostructured motherwort extract and its use in ice-cream production

2020 ◽  
pp. 10-16
Author(s):  
А.А. Krolevets ◽  
N.I. Myachikova ◽  
S.G. Glotova ◽  
K.M. Semichev ◽  
Ye.M. Mamayeva
Keyword(s):  
Sodium Alginate ◽  
Carboxymethyl Cellulose ◽  
Functional Food ◽  
Ice Cream ◽  
Food Product ◽  
Sodium Carboxymethyl Cellulose ◽  
Nanoparticle Tracking Analysis ◽  
Analysis Method ◽  
Average Size ◽  
Konjac Gum

The paper presents data on the use of nanostructured motherwort extract in ice-cream production to be used as a functional food product for preventive purposes. Using the Nanoparticle Tracking Analysis method (NTA method), we determined nanostructured motherwort extract sizes, depending, to a large extent, on the membrane. Thus, the size of motherwort extract nanocapsules greatly depends on the carbohydrate membrane nature: 10% of nanocapsules are from 63 to 88 nm, only in sodium alginate particles are smaller 3 25 nm. The smallest average nanocapsule size is 192 nm in konjac gum, the average 227.00-249.80 nm in carrageenan and sodium alginate, respectively, the highest average size (322 nm) is in sodium carboxymethyl cellulose.

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