To determine whether first-degree male relatives of women with polycystic ovary syndrome are at higher risk of developing cardiovascular disease and type II diabetes mellitus

2007 ◽  
Vol 27 (6) ◽  
pp. 591-596 ◽  
Author(s):  
A. Hunter ◽  
S. Vimplis ◽  
A. Sharma ◽  
N. Eid ◽  
W. Atiomo
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Polycystic Ovary Syndrome ◽  
Type Ii Diabetes ◽  
Polycystic Ovary ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Ovary Syndrome

scholarly journals Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome

Diabetologia ◽  
2002 ◽  
Vol 45 (7) ◽  
pp. 959-964 ◽  
Author(s):  
T. Sir-Petermann ◽  
B. Angel ◽  
M. Maliqueo ◽  
F. Carvajal ◽  
J. Santos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Type Ii Diabetes ◽  
Polycystic Ovary ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Ovary Syndrome

Is pseudocholinesterase activity related to markers of triacylglycerol synthesis in Type II diabetes mellitus?

2001 ◽  
Vol 101 (1) ◽  
pp. 29-35 ◽  
Author(s):  
C. RUSTEMEIJER ◽  
J. A. SCHOUTEN ◽  
H. J. VOERMAN ◽  
A. C. BEYNEN ◽  
A. J. M. DONKER ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Stepwise Multiple Regression ◽  
Type Ii ◽  
Stepwise Multiple Regression Analysis ◽  
Triacylglycerol Synthesis ◽  
The Relationship ◽  
Apoe Phenotype

Hypertriglyceridaemia is a risk factor for cardiovascular disease in patients suffering from Type II diabetes mellitus, and is due to enhanced synthesis and/or impaired clearance of triacylglycerol-rich lipoproteins. In the present study we investigated whether pseudocholinesterase (PChE) activity could serve as a marker for the rate of triacylglycerol synthesis in these patients. Patients were stratified according to their apolipoprotein E (apoE) phenotype, i.e. E3E2, E3E3 or E3E4. In study I, the relationship between PChE activity and serum triacylglycerols was investigated in 224 insulin-treated patients with Type II diabetes. In study II, which had a cross-over design, PChE activity was measured in 45 dyslipidaemic, insulin-treated patients with Type II diabetes that were treated with bezafibrate or pravastatin. In study I, PChE activity was correlated positively with serum triacylglycerol concentrations, but did not differ significantly between apoE phenotypes. The strongest relationship was found in the E3E4 group (r = 0.50; P = 0.001), the phenotype for which hypertriglyceridaemia is expected to be the result of increased triacylglycerol synthesis. In a stepwise multiple regression analysis, serum triacylglycerol concentrations were found to be the strongest predictor of PChE activity in the E3E4 group. In study II, PChE activity decreased as a result of bezafibrate treatment in all three apoE groups. The decrease in PChE activity with bezafibrate treatment paralleled the decrease in serum triacylglycerol concentrations in the apoE subgroups. Pravastatin treatment did not significantly affect PChE activity. Thus the present study suggests an association between PChE activity and the rate of triacylglycerol synthesis. Measurement of PChE activity may therefore be a useful tool in the choice of drug for treatment of hypertriglyceridaemia in patients with Type II diabetes.

scholarly journals ANÁLISE DA PRODUÇÃO CIENTÍFICA SOBRE POLIMORFISMO GENÉTICO EM SÍNDROME DOS OVÁRIOS POLICÍSTICOS E DOENÇAS CARDIOVASCULARES

2021 ◽  
Vol 9 (2) ◽  
pp. 85
Author(s):  
Camila Silva BELLA ◽  
Alessandra B. Trovó de MARQUI ◽  
Erika M. EGASHIRA ◽  
Mariangela Torreglosa Ruiz CINTRA
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Sindrome Metabolica ◽  
Pcr Rflp

A Síndrome dos Ovários Policísticos (SOP) é uma das endocrinopatologias mais comuns em mulheres na idade reprodutiva. Essas pacientes apresentam um risco elevado de obesidade, dislipidemia, resistência à insulina, diabetes mellitus tipo 2, síndrome metabólica e doenças cardiovasculares (DCVs). O objetivo do presente trabalho foi caracterizar a produção científica sobre polimorfismos genéticos e DCVs em SOP. Foi realizada pesquisa bibliográfica na base de dados PubMed com os seguintes termos: “genetic polymorphisms AND polycystic ovary syndrome AND cardiovascular disease”, nos últimos doze anos (2008-2020). Foram identificados 37 artigos e após aplicação dos critérios de inclusão e exclusão, 20 foram selecionados. Os principais resultados foram: 1) a maioria dos artigos (65%) não apresentou associação entre os genes e/ou polimorfismos com a SOP e DCVs; 2) os genes investigados estavam relacionados principalmente com os processos decorrentes das consequências clínicas da SOP, 3) houve predomínio da técnica de PCR – RFLP (45%) e 4) 50% dos estudos foram conduzidos na Turquia (30%) e Brasil (20%). Em conclusão, a caracterização dos trabalhos publicados de polimorfismos genéticos em SOP e DCVs foi expressiva, no entanto, os resultados preliminares sugerem que apenas os genes relacionados ao metabolismo de esteroides podem estar associados a estas condições.

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