scholarly journals ANÁLISE DA PRODUÇÃO CIENTÍFICA SOBRE POLIMORFISMO GENÉTICO EM SÍNDROME DOS OVÁRIOS POLICÍSTICOS E DOENÇAS CARDIOVASCULARES

2021 ◽  
Vol 9 (2) ◽  
pp. 85
Author(s):  
Camila Silva BELLA ◽  
Alessandra B. Trovó de MARQUI ◽  
Erika M. EGASHIRA ◽  
Mariangela Torreglosa Ruiz CINTRA
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Sindrome Metabolica ◽  
Pcr Rflp

A Síndrome dos Ovários Policísticos (SOP) é uma das endocrinopatologias mais comuns em mulheres na idade reprodutiva. Essas pacientes apresentam um risco elevado de obesidade, dislipidemia, resistência à insulina, diabetes mellitus tipo 2, síndrome metabólica e doenças cardiovasculares (DCVs). O objetivo do presente trabalho foi caracterizar a produção científica sobre polimorfismos genéticos e DCVs em SOP. Foi realizada pesquisa bibliográfica na base de dados PubMed com os seguintes termos: “genetic polymorphisms AND polycystic ovary syndrome AND cardiovascular disease”, nos últimos doze anos (2008-2020). Foram identificados 37 artigos e após aplicação dos critérios de inclusão e exclusão, 20 foram selecionados. Os principais resultados foram: 1) a maioria dos artigos (65%) não apresentou associação entre os genes e/ou polimorfismos com a SOP e DCVs; 2) os genes investigados estavam relacionados principalmente com os processos decorrentes das consequências clínicas da SOP, 3) houve predomínio da técnica de PCR – RFLP (45%) e 4) 50% dos estudos foram conduzidos na Turquia (30%) e Brasil (20%). Em conclusão, a caracterização dos trabalhos publicados de polimorfismos genéticos em SOP e DCVs foi expressiva, no entanto, os resultados preliminares sugerem que apenas os genes relacionados ao metabolismo de esteroides podem estar associados a estas condições.

The Impact of Obesity on Incidence of Type 2 Diabetes Mellitus (T2DM) among Women with Polycystic Ovary Syndrome (PCOS)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1612-P
Author(s):  
NADIRA SULTANA KAKOLY ◽  
ARUL EARNEST ◽  
HELENA TEEDE ◽  
LISA MORAN ◽  
DEBORAH LOXTON ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
The Impact

Insulin Therapy in Pregnancy Hypertensive Diseases and its Effect on the Offspring and Mother Later in Life

2019 ◽  
Vol 17 (5) ◽  
pp. 455-464 ◽  
Author(s):  
Alfonso Mate ◽  
Antonio J. Blanca ◽  
Rocío Salsoso ◽  
Fernando Toledo ◽  
Pablo Stiefel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Insulin Therapy ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Insulin Resistant ◽  
Hypertensive Disorders ◽  
The Impact ◽  
In Pregnancy

Pregnancy hypertensive disorders such as Preeclampsia (PE) are strongly correlated with insulin resistance, a condition in which the metabolic handling of D-glucose is deficient. In addition, the impact of preeclampsia is enhanced by other insulin-resistant disorders, including polycystic ovary syndrome and obesity. For this reason, there is a clear association between maternal insulin resistance, polycystic ovary syndrome, obesity and the development of PE. However, whether PE is a consequence or the cause of these disorders is still unclear. Insulin therapy is usually recommended to pregnant women with diabetes mellitus when dietary and lifestyle measures have failed. The advantage of insulin therapy for Gestational Diabetes Mellitus (GDM) patients with hypertension is still controversial; surprisingly, there are no studies in which insulin therapy has been used in patients with hypertension in pregnancy without or with an established GDM. This review is focused on the use of insulin therapy in hypertensive disorders in the pregnancy and its effect on offspring and mother later in life. PubMed and relevant medical databases have been screened for literature covering research in the field especially in the last 5-10 years.

scholarly journals Endocrinological and metabolic characteristics in patients who are non-obese and have polycystic ovary syndrome and different types of a family history of type 2 diabetes mellitus

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110166
Author(s):  
Yuan Wang ◽  
Hua Gao ◽  
Wen Di ◽  
Zhuowei Gu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
History Of ◽  
Second Degree

Objective We aimed to investigate whether patients with polycystic ovary syndrome (PCOS) and a family history (FH) of type 2 diabetes mellitus (T2DM) are at increased risk of endocrinological and metabolic abnormalities, and whether this risk differs between first-degree and second-degree relatives, and between maternal and paternal transmission. Methods A total of 680 patients with PCOS were enrolled in this retrospective, single-center study. Endocrine and glycolipid metabolism parameters were compared. Results The free androgen index (FAI), and levels of fasting blood glucose (FBG), fasting insulin (FINS), homeostatic model assessment-insulin resistance (HOMA-IR), total cholesterol (TC), and low-density lipoprotein cholesterol were significantly higher, whereas sex hormone binding globulin (SHBG) levels were significantly lower in patients with PCOS and a FH of T2DM. In patients with PCOS with a FH of T2DM in first-degree relatives, age and levels of FBG, FINS, and HOMA-IR were significantly higher than those who had a FH of T2DM in second-degree relatives. A maternal history of T2DM was associated with a higher body mass index, FAI, and TG levels, and lower SHBG levels. Conclusions Patients with PCOS and a FH of T2DM have more severe hyperandrogenism and metabolic disorders, especially in those with maternal transmission.

Serum anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus

Metabolism ◽  
2016 ◽  
Vol 65 (5) ◽  
pp. 804-811 ◽  
Author(s):  
Agnieszka Łebkowska ◽  
Agnieszka Adamska ◽  
Monika Karczewska-Kupczewska ◽  
Agnieszka Nikołajuk ◽  
Elżbieta Otziomek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Hormone Concentration ◽  
Ovary Syndrome
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