Methanol fraction of Ficus mucoso (welw) prevents iron-induced oxidative damage and alters mitochondrial dysfunction in Drosophila melanogaster

2021 ◽  
pp. 1-9
Author(s):  
Olubukola T. Oyebode ◽  
Amos O. Abolaji ◽  
Hammed O. Faleke ◽  
Olufunso O. Olorunsogo
Keyword(s):  
Drosophila Melanogaster ◽  
Oxidative Damage ◽  
Mitochondrial Dysfunction ◽  
Methanol Fraction

Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity

2016 ◽  
Vol 68 (9) ◽  
pp. 1222-1232 ◽  
Author(s):  
Mohammad Reza Sepand ◽  
Mohammad Hossein Ghahremani ◽  
Kamal Razavi-Azarkhiavi ◽  
Mehdi Aghsami ◽  
Jalil Rajabi ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Mitochondrial Dysfunction ◽  
Ellagic Acid

scholarly journals Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage

2015 ◽  
Vol 1852 (10) ◽  
pp. 2066-2074 ◽  
Author(s):  
Carlo Cervellati ◽  
Claudia Sticozzi ◽  
Arianna Romani ◽  
Giuseppe Belmonte ◽  
Domenico De Rasmo ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Mitochondrial Dysfunction ◽  
Defensive Activity

Hippocampal mitochondrial dysfunction in rat aging

2008 ◽  
Vol 294 (2) ◽  
pp. R501-R509 ◽  
Author(s):  
Ana Navarro ◽  
José M. López-Cepero ◽  
Manuel J. Bández ◽  
María-Jesús Sánchez-Pino ◽  
Carmen Gómez ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Enzymatic Activity ◽  
Mitochondrial Dysfunction ◽  
Thiobarbituric Acid ◽  
Statistical Correlation ◽  
Protein Carbonyls ◽  
Complex Iv ◽  
Mitochondrial Nitric Oxide Synthase ◽  
Mitochondrial Oxidative Damage ◽  
Oxide Synthase

Hippocampus mitochondrial dysfunction with impaired electron transfer and increased oxidative damage was observed upon rat aging. Hippocampal mitochondria of aged (12 mo) and senescent (20 mo) rats showed, compared with young (4 mo) rats, marked decreases in the rate of state 3 respiration with NAD-dependent substrates (32–51%) and in the activities of mitochondrial complexes I (57–73%) and IV (33–54%). The activity of mitochondrial nitric oxide synthase was also decreased, 53–66%, with age. These losses in enzymatic activity were more marked in the hippocampus than in brain cortex or in whole brain. The histochemical assay of mitochondrial complex IV in the hippocampus showed decreased staining upon aging. Oxidative damage, determined as the mitochondrial content of thiobarbituric-acid reactive substances (TBARS) and protein carbonyls, increased in aged and senescent hippocampus (66–74% in TBARS and 48–96% in carbonyls). A significant statistical correlation was observed between mitochondrial oxidative damage and enzymatic activity. Mitochondrial dysfunction with shortage of energy supply is considered a likely cause of dysfunction in aged hippocampus.

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