The essence and goals of the defense in the criminal procedure

The article investigates questions about the essence of criminal defense, its goals and properties. The authors note that, for all its specifi city, criminal procedural protection has a number of properties inherent in any type of defensive activity, but at the same time its independence is the defi ning property of protection in criminal procedure. The article is devoted to the problems of scientifi c and legislative refl ection of the defense in the criminal procedure. Comparing the history of legal regulation of the defense in criminal proceedings in various European states, the authors come to the conclusion on the lack of the consistent and structural approach in those legislative attempts. At the same time, the article tries to classify scientifi c approaches to the goals and properties of the criminal defense. Based on the analysis of the current legislation, as well as literature, fi ve fundamental properties of the criminal defense (independence, aleatory, proficiency, sub legislative character, efficiency) are identified.

Defensive activity of Hesperidin against Ciprofloxacin induced hepatic injury in rabbits.

This study was conducted to find out hepatoprotective activity of hesperidin (HES) 100mg/kg body weight (b.w.) against ciprofloxacin (CPX) 100 mg/kg induced hepatotoxicity in local breed rabbits .CPX is a broad spectrum antibiotic used for treatment of many bacterial infections. Twenty four male rabbits were divided into four groups ,group1: control, (1 ml/kg Saline orally) group 2: CPX (100 mg/kg orally) for (14) consecutive days , group 3: HES (100 mg//kg) orally for (14) consecutive days group 4: CPX (100 mg/kg orally) plus HES (100 mg//kg orally ) for (14) consecutive days. All the rabbits were killed on the (15) day of the experiment, and then the blood, and livers samples were taken. CPX induced hepatotoxicity was proved by a significant (p less than 0.01) reduction in the body weight ,and a significant (p less than 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT) , Malonaldehyde enzyme (MAD) and histopathological changes. Protective hepatic toxicity effect and oxidative damage caused by CPX significantly (p less than 0.01) increasing in body weight and significantly (p less than 0.01) decreasing AST , ALT, MAD and improving tissue morphology in HES (100 mg//kg) . These results assure that HES (100 mg//kg) antioxidant effects can protect CPX-induced hepatotoxicity in rabbits.

Problems of Cancer Treatment. Part I. Theory of Treatment Based on Known Mechanisms of Anticancer Immunological Responses

SummaryVarious processes, taking place both in cells and in their environment, are linked to carcinogenesis. This paper aims at recalling the complex mechanisms of oncogenesis, with particular attention paid to responses of the immune system. In development of solid tumours, leukaemias and lymphomas several common stages can be noted. A neoplastic disease cannot be understood considering only phenomena of genetic mutations. Neoplastic cells are characterised by an extensive antigenic variability and resistance to apoptosis. The cells create around them a microenvironment which protects them from defensive activity of the host. In the paper we present the recognised mechanisms of anti-neoplastic defense as well as several elements allowing the solid tumours and leukaemias to escape from the immune surveillance. The generally accepted treatment of tumours aims at reducing numbers of tumour cells. Following resection of a tumour, radiotherapy or chemotherapy, the parallel or consecutive stage of treatment was found to involve an increase in number of clones of immune system cells. One of the ways in which the immune system can be activated involves autovaccination of the host with own neoplastic cells in an apoptosis. However, attempts of such a therapy frequently brought no expected results due to blocked activity of cytotoxic cells. Therefore, the subsequent stage in activation of the immune system should involve elimination of the tumor-mobilized blockade of the system. Attempts toward this aim include neutralization of the tumour-blocked cytotoxic properties of defensive cells, first of all T lymphocytes. The recognized mechanisms of blocking T cells activity in the PD-1/PD-L1 system or due to inhibition of activation by CTLA-4 molecule provided rationale for development of effective tumour immunotherapy approaches.

On Some Tendencies in Defense Policy of Germany

The paper discusses the newest trends in the German defense policy, caused by the aggravation of European geopolitical situation. The author analyzes various sources, among them official reports presented to the Ministry of Defense and the Bundestag; speeches by the Minister of Defense and by supreme commanders of the Bundeswehr; published in mass media information on condition and problems of the military forces, as well as modernization of the equipment. Officially it is deemed, that the reform of the Bundeswehr which started in 2011, so far has turned into an amorphous process of renewal (Neuausrichtung), intended to improve the military organization. Since the acting Cabinet was farmed, Ursula von der Leyen - the first woman Minister of Defense of Germany - directs these activities, and her style of work affects all the work in the Ministry. Meanwhile, the revision of the main parameters of the defensive activity and the whole German politics is caused not by a fresh leadership, but by the most sharp after the end of the "cold war" geopolitical crisis in Europe. The author comes to conclusion, that a turning point in the Defensive Policy of Germany is taking shape, so that all the aspects of military organization are now affected: command stuff training, military equipment, strengthening of ties with allies. Anti-Russian propaganda in mass-media reanimates an image of an enemy and prepares public opinion to the future growth of military expenses; it even overcomes certain pacifism, so usual in modern society. Here in Russia, one must take all this into account, as an idea of the low fighting capacity of the Bundeswehr, which was formed in the last years, is getting obsolete, and could became a dangerous illusion.

Strong Sour Tamarind Flavor of Methyl-2,3,4- trihydroxyhexanoate, a new compound isolated from Leaves of Tamarindus indica, L. plays a role in plant defense mechanisms

Flavoring compounds of plants play a significant role in plant defense mechanism. Compound responsible for strong sour tamarind flavor has been isolated and identified from Methanol fraction of tamarind leaves (TrMF). Chromatographic and spectral analyses of TrMF revealed the compound to be methyl 2,3,4- trihydroxyhexanoate. This compound showed a strong antioxidant activity as well as strong antimicrobial activity. It showed significant antioxidant activity with Ic50 value of 2.5μg/ml whereas tert-butyl-1-hydroxytoluene and ascorbic acid revealed 26.0μg/ml and 5.0μg/ml, respectively. It also revealed strong inhibitory activity against Aspergellosis disease-causing fungi namely; Aspergillus fumigatus, Aspergillus tamarii and Aspergillus niger at all concentrations. Streptococcus aureus and Escherichia coli were much more sensitive to methyl-trihydroxy-hexanoate at all concentrations than Pseudomonas aeruginosa. This pure compound exhibited concentration dependent inhibitory and stimulatory activity on rice seeds germination and seedling growth. It showed strong inhibitory activity up to 62.5ppm concentration and below this concentration the effect was stimulatory. Methyl- trihydroxyhexanoate exhibited wide range of defensive activity against microbes and crop seeds and also possesses potent antioxidative activity. Thus play an important role in plant defense mechanism and can be utilized as a valuable source of bio-herbicides and pesticides.

The Chitin-Binding Cladosporium fulvum Effector Protein Avr4 Is a Virulence Factor

The biotrophic fungal pathogen Cladosporium fulvum (syn. Passalora fulva) is the causal agent of tomato leaf mold. The Avr4 protein belongs to a set of effectors that is secreted by C. fulvum during infection and is thought to play a role in pathogen virulence. Previous studies have shown that Avr4 binds to chitin present in fungal cell walls and that, through this binding, Avr4 can protect these cell walls against hydrolysis by plant chitinases. In this study, we demonstrate that Avr4 expression in Arabidopsis results in increased virulence of several fungal pathogens with exposed chitin in their cell walls, whereas the virulence of a bacterium and an oomycete remained unaltered. Heterologous expression of Avr4 in tomato increased the virulence of Fusarium oxysporum f. sp. lycopersici. Through tomato GeneChip analyses, we demonstrate that Avr4 expression in tomato results in the induced expression of only a few genes. Finally, we demonstrate that silencing of the Avr4 gene in C. fulvum decreases its virulence on tomato. This is the first report on the intrinsic function of a fungal avirulence protein that has a counter-defensive activity required for full virulence of the pathogen.