scholarly journals Urinary Isothiocyanates Level and Liver Cancer Risk: A Nested Case-Control Study in Shanghai, China

2014 ◽  
Vol 66 (6) ◽  
pp. 1023-1029 ◽  
Author(s):  
Qi-Jun Wu ◽  
Jing Wang ◽  
Jing Gao ◽  
Wei Zhang ◽  
Li-Hua Han ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Genetic polymorphism ofNFKB1andNFKBIAgenes and liver cancer risk: a nested case–control study in Shanghai, China

BMJ Open ◽  
2014 ◽  
Vol 4 (2) ◽  
pp. e004427 ◽  
Author(s):  
Jing Gao ◽  
Hong-Li Xu ◽  
Shan Gao ◽  
Wei Zhang ◽  
Yu-Ting Tan ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association between DPP-4 inhibitors and events of colorectal and liver cancers in patients with diabetes receiving second-line agents: a nested case-control study

2020 ◽  
Author(s):  
Chu-Lin Chou ◽  
Shu-Hui Juan ◽  
Hsi-Hsien Chen ◽  
Chih-Chin Kao ◽  
Yueh-Lin Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Second Line ◽  
Liver Cancers ◽  
Patients With Diabetes ◽  
Nested Case Control ◽  
Control Study

Abstract Background and aim: Several studies showed plasma dipeptidyl peptidase-4 (DPP4) levels were significantly lower in patients with colorectal and liver cancers, and animal studies also showed DPP4 inhibitors (DPP4is) have procarcinogenic effects in colorectal cancer. The aims of this study were to investigate the association between cumulative defined daily dose (cDDD) of DPP4is exposure and risks of liver and colorectal cancers in patients with type 2 diabetes mellitus. Methods In this nested case-control study, we identified 268,520 patients with diabetes receiving DPP4is as second-line agents between March 1, 2009, and December 31, 2013, from Taiwan’s National Health Insurance Research Database, Taiwan Cancer Registry, and National Death Registry of Taiwan. Of these, 948 and 990 patients newly were diagnosed with liver and colorectal cancer, respectively. The amount of DPP4is were divided into three groups (low, medium, and high) based on the interquartile range of the cDDD of the DPP4is. Results: The data showed that the low cDDD of DPP-4is was associated with a reducing risk of colorectal cancer [adjusted odds ratio (OR), 0.49; 95% CI, 0.32–0.75; P = 0.001]. However, the high cDDD of DPP-4is was associated with an increasing risk of colorectal cancer (adjusted OR, 1.86; 95% CI, 1.32–2.61; P < 0.001). No association between DPP4is use and liver cancer risk was observed. Conclusions The novel finding of this nested case study revealed a J-shaped association between the cDDD of DPP-4is and colorectal cancer risk, but not liver cancer risk. A large-based longitudinal investigation is necessary to determine whether long-term DPP4is exposure increase colorectal cancer risk.

Posttraumatic Stress Disorder and Cancer Risk: A Nested Case‐Control Study

2018 ◽  
Vol 31 (6) ◽  
pp. 919-926
Author(s):  
Elana Cohn ◽  
Ido Lurie ◽  
Yu‐Xiao Yang ◽  
Warren B. Bilker ◽  
Kevin Haynes ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Cancer Risk ◽  
Posttraumatic Stress ◽  
Case Control Study ◽  
Stress Disorder ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Lung cancer risk in iron and steel foundry workers: A nested case control study in Asturias, Spain

2000 ◽  
Vol 38 (6) ◽  
pp. 644-650 ◽  
Author(s):  
Valent�n Rodr�guez ◽  
Adonina Tard�n ◽  
Manolis Kogevinas ◽  
Carlos S. Prieto ◽  
Antonio Cueto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Iron And Steel ◽  
Nested Case Control ◽  
Foundry Workers ◽  
Control Study

scholarly journals A Prospective Nested Case-Control Study of Vitamin D Status and Pancreatic Cancer Risk in Male Smokers

2006 ◽  
Vol 66 (20) ◽  
pp. 10213-10219 ◽  
Author(s):  
Rachael Z. Stolzenberg-Solomon ◽  
Reinhold Vieth ◽  
Azar Azad ◽  
Pirjo Pietinen ◽  
Philip R. Taylor ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Status ◽  
Pancreatic Cancer Risk ◽  
Nested Case Control ◽  
Control Study

scholarly journals The association of POLR2E rs3787016 polymorphism and cancer risk: a Chinese case–control study and meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Bifeng Chen ◽  
Shang Wang ◽  
Guangxin Ma ◽  
Jin Han ◽  
Jingli Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lung Cancer ◽  
Liver Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
A Genome ◽  
Control Study

How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.

scholarly journals Circulating carotenoids and breast cancer among high-risk individuals

2020 ◽  
Author(s):  
Cheng Peng ◽  
Chi Gao ◽  
Donghao Lu ◽  
Bernard A Rosner ◽  
Oana Zeleznik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Risk ◽  
Case Control Study ◽  
Case Control ◽  
Polygenic Risk Score ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Carotenoids represent 1 of few modifiable factors to reduce breast cancer risk. Elucidation of interactions between circulating carotenoids and genetic predispositions or mammographic density (MD) may help inform more effective primary preventive strategies in high-risk populations. Objectives We tested whether women at high risk for breast cancer due to genetic predispositions or high MD would experience meaningful and greater risk reduction from higher circulating levels of carotenoids in a nested case-control study in the Nurses’ Health Studies (NHS and NHSII). Methods This study included 1919 cases and 1695 controls in a nested case-control study in the NHS and NHSII. We assessed both multiplicative and additive interactions. RR reductions and 95% CIs were calculated using unconditional logistic regressions, adjusting for matching factors and breast cancer risk factors. Absolute risk reductions (ARR) were calculated based on Surveillance, Epidemiology, and End Results incidence rates. Results We showed that compared with women at low genetic risk or low MD, those with higher genetic risk scores or high MD had greater ARRs for breast cancer as circulating carotenoid levels increase (additive P-interaction = 0.05). Among women with a high polygenic risk score, those in the highest quartile of circulating carotenoids had a significant ARR (28.6%; 95% CI, 14.8–42.1%) compared to those in the lowest quartile of carotenoids. For women with a high percentage MD (≥50%), circulating carotenoids were associated with a 37.1% ARR (95% CI, 21.7–52.1%) when comparing the highest to the lowest quartiles of circulating carotenoids. Conclusions The inverse associations between circulating carotenoids and breast cancer risk appeared to be more pronounced in high-risk women, as defined by germline genetic makeup or MD.

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