Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

2019 ◽  
Vol 71 (8) ◽  
pp. 1313-1324 ◽  
Author(s):  
L. Katsidzira ◽  
S. Ocvirk ◽  
A. Wilson ◽  
J. Li ◽  
C. B. Mahachi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Colorectal Cancer Risk ◽  
Short Chain ◽  
Dietary Changes ◽  
Chain Fatty Acids

scholarly journals Association Between Low Colonic Short-Chain Fatty Acids and High Bile Acids in High Colon Cancer Risk Populations

2012 ◽  
Vol 64 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Junhai Ou ◽  
James P. DeLany ◽  
Ming Zhang ◽  
Sumit Sharma ◽  
Stephen J. D. O’Keefe
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Cancer Risk ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Colon Cancer Risk ◽  
Chain Fatty Acids

scholarly journals Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2464
Author(s):  
Zhan-Dong Yang ◽  
Yi-Shan Guo ◽  
Jun-Sheng Huang ◽  
Ya-Fei Gao ◽  
Fei Peng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Control Group ◽  
Secondary Bile Acid ◽  
Prebiotic Activity ◽  
Secondary Bile Acids ◽  
Chain Fatty Acids

In vitro experiments have indicated prebiotic activity of isomaltulose, which stimulates the growth of probiotics and the production of short chain fatty acids (SCFAs). However, the absence of in vivo trials undermines these results. This study aims to investigate the effect of isomaltulose on composition and functionality of gut microbiota in rats. Twelve Sprague–Dawley rats were divided into two groups: the IsoMTL group was given free access to water containing 10% isomaltulose (w/w), and the control group was treated with normal water for five weeks. Moreover, 16S rRNA sequencing showed that ingestion of isomaltulose increased the abundances of beneficial microbiota, such as Faecalibacterium and Phascolarctobacterium, and decreased levels of pathogens, including Shuttleworthia. Bacterial functional prediction showed that isomaltulose affected gut microbial functionalities, including secondary bile acid biosynthesis. Targeted metabolomics demonstrated that isomaltulose supplementation enhanced cholic acid concentration, and reduced levels of lithocholic acid, deoxycholic acid, dehydrocholic acid, and hyodeoxycholic acid. Moreover, the concentrations of propionate and butyrate were elevated in the rats administered with isomaltulose. This work suggests that isomaltulose modulates gut microbiota and the production of SCFAs and secondary bile acids in rats, which provides a scientific basis on the use of isomaltulose as a prebiotic.

scholarly journals Relationships of Gut Microbiota Composition, Short-Chain Fatty Acids and Polyamines with the Pathological Response to Neoadjuvant Radiochemotherapy in Colorectal Cancer Patients

2021 ◽  
Vol 22 (17) ◽  
pp. 9549
Author(s):  
Lidia Sánchez-Alcoholado ◽  
Aurora Laborda-Illanes ◽  
Ana Otero ◽  
Rafael Ordóñez ◽  
Alicia González-González ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Gut Microbiota ◽  
Microbial Diversity ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Neoadjuvant Radiochemotherapy ◽  
Microbiota Composition ◽  
Gut Microbiota Composition ◽  
Chain Fatty Acids

Emerging evidence has suggested that dysbiosis of the gut microbiota may influence the drug efficacy of colorectal cancer (CRC) patients during cancer treatment by modulating drug metabolism and the host immune response. Moreover, gut microbiota can produce metabolites that may influence tumor proliferation and therapy responsiveness. In this study we have investigated the potential contribution of the gut microbiota and microbial-derived metabolites such as short chain fatty acids and polyamines to neoadjuvant radiochemotherapy (RCT) outcome in CRC patients. First, we established a profile for healthy gut microbiota by comparing the microbial diversity and composition between CRC patients and healthy controls. Second, our metagenomic analysis revealed that the gut microbiota composition of CRC patients was relatively stable over treatment time with neoadjuvant RCT. Nevertheless, treated patients who achieved clinical benefits from RTC (responders, R) had significantly higher microbial diversity and richness compared to non-responder patients (NR). Importantly, the fecal microbiota of the R was enriched in butyrate-producing bacteria and had significantly higher levels of acetic, butyric, isobutyric, and hexanoic acids than NR. In addition, NR patients exhibited higher serum levels of spermine and acetyl polyamines (oncometabolites related to CRC) as well as zonulin (gut permeability marker), and their gut microbiota was abundant in pro-inflammatory species. Finally, we identified a baseline consortium of five bacterial species that could potentially predict CRC treatment outcome. Overall, our results suggest that the gut microbiota may have an important role in the response to cancer therapies in CRC patients.

scholarly journals Development of Gut Microbiota Along with its Metabolites of Preschool Children

2021 ◽  
Author(s):  
Jingjing Xiong ◽  
Hongwei Hu ◽  
Chuanzhi Xu ◽  
Jianwen Yin ◽  
Mei Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Preschool Children ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Intestinal Microflora ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Healthy Children ◽  
Chain Fatty Acids

Abstract Aim: To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Methods: Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. Results: The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2-3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. Conclusion: The age of 6 months may be a critical period for the development of intestinal microflora in children.

scholarly journals Development of gut microbiota along with its metabolites of preschool children

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Jingjing Xiong ◽  
Hongwei Hu ◽  
Chuanzhi Xu ◽  
Jianwen Yin ◽  
Mei Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Preschool Children ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Intestinal Microflora ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Healthy Children ◽  
Chain Fatty Acids

Abstract Background To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Methods Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. Results The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2–3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. Conclusion The age of 6 months may be a critical period for the development of intestinal microflora in children.

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