Delayed implant infection with Cutibacterium acnes (Propionibacterium acnes) 30 years after silicone sheet orbital floor implant

Propionibacterium acnes (Cutibacterium acnes) is an anaerobic, gram-positive, slow growing bacteria. It can produce various virulence factors like bioactive exocellular products and metabolites. P.acnes blood isolates were considered signicant if two or more separate blood culture sets were positive on the same day and if systemic inammatory response syndrome (SIRS) was present without any alternate explanation. C.acnes if found in the blood of patients with implantable cardiac devices it should be considered as more than just a skin contaminant. These patients should be treated with appropriate therapies to prevent annihilatory consequences.

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Proposal of new combination, Cutibacterium acnes subsp. elongatum comb. nov., and emended descriptions of the genus Cutibacterium, Cutibacterium acnes subsp. acnes and Cutibacterium acnes subsp. defendens

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY ◽

10.1099/ijsem.0.003274 ◽

2019 ◽

Vol 69 (4) ◽

pp. 1087-1092 ◽

Cited By ~ 13

Author(s):

Itaru Dekio ◽

Andrew McDowell ◽

Mitsuo Sakamoto ◽

Shuta Tomida ◽

Moriya Ohkuma

Keyword(s):

Mass Spectrometry ◽

Type Strain ◽

Type Species ◽

Propionibacterium Acnes ◽

New Combination ◽

Content Type ◽

Maldi Tof Mass Spectrometry ◽

Link Type ◽

Maldi Tof ◽

Cutibacterium Acnes

In 2016, division of the genus Propionibacterium into four distinct genera was proposed. As a consequence, the species Propionibacterium acnes was transferred to Cutibacterium gen. nov. as Cutibacterium acnes comb. nov. The three recently proposed subspecies of P. acnes were not, however, accommodated in this proposal. Following a very recent validation of a new combination for C. acnes subsp. defendens and an automatically created C. acnes subsp. acnes , we now propose the new combination, C. acnes subsp. elongatum comb. nov. The type strain of Cutibacterium acnes subsp. elongatum is JCM 18919T (=NCTC 13655T). On the basis of further genomic and phenotypic (haemolysis and MALDI-TOF mass spectrometry) analyses of these subspecies, we also provide emended descriptions of the genus Cutibacterium Scholz and Kilian 2016, C. acnes subsp. acnes (Gilchrist 1900) Nouioui et al. 2018, and C. acnes subsp. defendens (McDowell et al. 2016) Nouioui et al. 2018.

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Low sensitivity of histopathological examination of peri-implant tissue samples in diagnosing postoperative spinal implant infection

The Bone & Joint Journal ◽

10.1302/0301-620x.102b7.bjj-2019-1725.r2 ◽

2020 ◽

Vol 102-B (7) ◽

pp. 899-903

Author(s):

Justus Bürger ◽

Yannick Palmowski ◽

Patrick Strube ◽

Carsten Perka ◽

Michael Putzier ◽

...

Keyword(s):

Spinal Surgery ◽

Histopathological Examination ◽

Clinical Signs ◽

Implant Infection ◽

Tissue Samples ◽

Spinal Implant ◽

Cutibacterium Acnes ◽

Microbiological Examination ◽

Study Population ◽

Low Sensitivity

Aims To evaluate the histopathological examination of peri-implant tissue samples as a technique in the diagnosis of postoperative spinal implant infection (PSII). Methods This was a retrospective analysis. Patients who underwent revision spinal surgery at our institution were recruited for this study. PSII was diagnosed by clinical signs, histopathology, and microbiological examination of intraoperatively collected samples. Histopathology was defined as the gold standard. The sensitivity for histopathology was calculated. A total of 47 patients with PSII and at least one microbiological and histopathological sample were included in the study. Results PSII occurred in approximately 28% of the study population. Histopathology showed a sensitivity of 51.1% in the diagnosis of PSII. The most commonly found pathogens were Cutibacterium acnes and gram-positive staphylococci. Conclusion Histopathology has low sensitivity for detecting PSII. In particular, infections caused by low-virulence microorganisms are insufficiently detected by histopathology. Cite this article: Bone Joint J 2020;102-B(7):899–903.

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Cutibacterium acnes (formerly Propionibacterium acnes) isolated from prosthetic joint infections is less susceptible to oxacillin than to benzylpenicillin

Journal of Bone and Joint Infection ◽

10.7150/jbji.30954 ◽

2019 ◽

Vol 4 (3) ◽

pp. 106-110 ◽

Cited By ~ 2

Author(s):

Sara Ridberg ◽

Bengt Hellmark ◽

Åsa Nilsdotter ◽

Bo Söderquist

Keyword(s):

Minimum Inhibitory Concentration ◽

Prophylactic Treatment ◽

Inhibitory Concentration ◽

Propionibacterium Acnes ◽

Joint Infections ◽

Randomized Controlled Studies ◽

Prosthetic Joint ◽

Prosthetic Joint Infections ◽

Cutibacterium Acnes ◽

Antibiotic Agents

Abstract. Introduction: The frequency of prosthetic joint infections (PJIs) due to Cutibacterium acnes (formerly Propionibacterium acnes) is increasing, especially shoulder PJIs. The recommended antibiotic prophylaxis for hip and knee arthroplasties is beta-lactam antibiotics, predominantly cephalosporins. However, for example in Sweden, isoxazolyl-penicillin cloxacillin is used. No specific recommendations for shoulder arthroplasties are available. The aim of the present study was to determine the minimum inhibitory concentration (MIC) values for different antibiotics for C. acnes; and, more specifically, to compare the MIC values for benzylpenicillin and oxacillin.Materials and methods: Minimum inhibitory concentration (MIC) values for nine different antibiotic agents were obtained by gradient test (Etest) using strains of C. acnes (n= 57) isolated from PJIs from shoulders (n=31), hips (n=21), and knees (n=5).Results: All isolates had low MIC values for most of the tested antibiotic agents, and showed a wild type MIC distribution. The exception was clindamycin with 9% of the isolates displaying decreased susceptibility. The MIC values obtained for benzylpenicillin were significantly lower than the MIC values for isoxazolyl-penicillin (oxacillin).Conclusion: These in vitro results indicate that benzylpenicillin might be a more effective prophylactic treatment to prevent shoulder PJIs caused by C. acnes. However, further studies on the subject are needed, and the effectiveness of the prophylactic treatment should be evaluated using randomized controlled studies and/or register-based studies.

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Evaluación de las características fisicoquímicas y de la actividad antimicrobiana del aceite del árbol de té contra Cutibacterium acnes (Propionibacterium acnes) ATCC 6919

Biomédica ◽

10.7705/biomedica.5122 ◽

2020 ◽

Vol 40 (4) ◽

pp. 693-701

Author(s):

Johana Carolina Ossa-Tabares ◽

Claudia Jimena Llanos ◽

Ana María García

Keyword(s):

Propionibacterium Acnes ◽

Cutibacterium Acnes

Introducción. El aceite del árbol de té es un aceite esencial reconocido por sus propiedades antimicrobianas.Objetivos. Evaluar la composición, características y efecto antimicrobiano del aceite al 2 % del árbol de té y su concentración inhibitoria mínima (CIM) contra Cutibacterium acnes (Propionibacterium acnes).Materiales y métodos. Se evaluó el quimiotipo en tres lotes diferentes de este aceite mediante cromatografía de gases, así como su actividad antimicrobiana en concentración al 2 % v/v y la CIM contra C. acnes mediante ensayo de difusión en agar (guía M11-A8 CLSI).Resultados. Los lotes evaluados presentaron los quimiotipos ajustados a la norma ISO 4730, lo que indicó la alta calidad del producto. Los lotes contenían de 30 a 40 % de terpinen-4-ol, compuesto que favorece la actividad antimicrobiana, la cual presentó en todos los lotes un efecto dependiente de la concentración contra C. acnes, con una inhibición del crecimiento microbiano en concentración al 2 % v/v en todas las pruebas. La concentración inhibitoria mínima fue de 0,25 % v/v. La actividad antimicrobiana del aceite del árbol de té contra este microorganismo ya ha sido reportada con una concentración inhibitoria mínima entre 0,05 y 1,25 % v/v, rango que cobija la obtenida en este estudio.Conclusiones. Los resultados evidenciaron la gran calidad de este producto y su capacidad como agente antibacteriano contra C. acnes. Se deben hacer estudios con otros aislamientos del microorganismo provenientes de pacientes con acné vulgar para confirmar su actividad general y la de cada uno de sus componentes.

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