The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells

2021 ◽  
pp. 1-12
Author(s):  
Ke Ma ◽  
Wei Wang ◽  
Chunyan Gao ◽  
Jine He
Keyword(s):  
Acute Inflammation ◽  
Human Lung ◽  
Lung Fibroblast ◽  
Human Lung Fibroblast

Hormetic effects of noncoplanar PCB exposed to human lung fibroblast cells (HELF) and possible role of oxidative stress

2014 ◽  
Vol 30 (12) ◽  
pp. 1385-1392 ◽  
Author(s):  
Muhammad Zaffar Hashmi ◽  
Kiran Yasmin Khan ◽  
Jinxing Hu ◽  
Naveedullah ◽  
Xiaomei Su ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Lung ◽  
Lung Fibroblast ◽  
Fibroblast Cells ◽  
Human Lung Fibroblast

scholarly journals Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production

1999 ◽  
Vol 93 (9) ◽  
pp. 637-642 ◽  
Author(s):  
S. Matsui ◽  
N. Yamashita ◽  
T. Mino ◽  
H. Taki ◽  
E. Sugiyama ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Human Lung ◽  
Lung Fibroblast ◽  
Human Lung Fibroblast ◽  
Endogenous Prostaglandin ◽  
Interleukin 11

Effects of silica on human lung fibroblast in culture

2001 ◽  
Vol 270 (1-3) ◽  
pp. 135-139 ◽  
Author(s):  
G Arcangeli ◽  
V Cupelli ◽  
G Giuliano
Keyword(s):  
Human Lung ◽  
Lung Fibroblast ◽  
Human Lung Fibroblast

Surfactant downregulates synthesis of DNA and inflammatory mediators in normal human lung fibroblasts

1996 ◽  
Vol 270 (1) ◽  
pp. L159-L163 ◽  
Author(s):  
M. J. Thomassen ◽  
J. M. Antal ◽  
B. P. Barna ◽  
L. T. Divis ◽  
D. P. Meeker ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Human Lung ◽  
Thymidine Incorporation ◽  
Interleukin 1 ◽  
S Phase ◽  
Lung Fibroblast ◽  
Lung Fibroblasts ◽  
Human Lung Fibroblast ◽  
Normal Human

The initial inflammatory event in the adult respiratory distress syndrome (ARDS) is followed by fibroproliferation and a cascade of fibroblast-derived mediators. Because lung fibroblasts may be exposed to surfactant as well as inflammatory cytokines during ARDS, we hypothesized that surfactant might modulate fibroblast activity. We previously demonstrated that surfactant inhibited production of inflammatory cytokines from endotoxin-stimulated human alveolar macrophages. In the current study the effects of surfactant on normal human lung fibroblast proliferative capacity and mediator production were examined. Both synthetic (Exosurf) and natural (Survanta) surfactant inhibited fibroblast [3H]thymidine incorporation. Examination of pre-S-phase events indicated stimulation of the immediate response gene, c-fos, and no effect on the G1/S cyclin, cyclin D1, suggesting that the surfactant block occurred elsewhere before S phase. The antioxidant N-acetyl-L-cysteine (NAC), like surfactant, inhibited [3H]thymidine incorporation. Furthermore, menadione, a generator of intracellular H2O2, stimulated fibroblast [3H]thymidine incorporation, and this was inhibited by surfactant. Interleukin-1 (IL-1)-stimulated secretion of the inflammatory mediators, IL-6 and prostaglandin E2, was also inhibited by surfactant. These data suggest that surfactant may modify lung fibroblast participation in ARDS sequelae by downregulating DNA synthesis and secondary inflammatory mediator production.

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