Neural reactivity parameters of awareness predetermine one-year survival in patients with disorders of consciousness

Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction. This study aimed to develop a multidomain prognostic model that combines resting state functional MRI with three clinical characteristics to predict one year-outcomes at the single-subject level. The model discriminated between patients who would later recover consciousness and those who would not with an accuracy of around 88% on three datasets from two medical centers. It was also able to identify the prognostic importance of different predictors, including brain functions and clinical characteristics. To our knowledge, this is the first reported implementation of a multidomain prognostic model that is based on resting state functional MRI and clinical characteristics in chronic disorders of consciousness, which we suggest is accurate, robust, and interpretable.

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PSYCHOTHERAPEUTIC CORRECTION SYSTEM OF SOMATOGENIC DEPRESSIVE DISORDERS IN PATIENTS WITH CEREBRAL STROKE

Inter Collegas ◽

10.35339/ic.3.4.190-196 ◽

2017 ◽

Vol 3 (4) ◽

pp. 190-196

Author(s):

V. Mykhaylov ◽

H. Kozhyna ◽

I. Zdesenko

Keyword(s):

Emotional Disorders ◽

Depressive Disorders ◽

Cognitive Impairments ◽

Disorders Of Consciousness ◽

Cerebral Stroke ◽

Improve Quality ◽

Depression And Anxiety ◽

One Year ◽

Correction System

The article shows the results of examination of 60 patients with cerebral stroke. The study implied the assessment of the development of somatogenic depressive disorders for one year. Acute phase of cerebral stroke was characterized by various disorders of consciousness which were further accompanied by cognitive impairments, and after disorders of consciousness disappeared patients developed various psycho-emotional disorders, predominantly somatogenic depression and anxiety. The proposed psychotherapeutic correction system has allowed to reduce the frequency and severity of this disorders and to improve quality of life and social functioning of post-stroke patients.KeyWords: Somatogenic depression, anxiety, psychotherapy, cerebral stroke.Михайлов В.Б., Кожина Г.М., Здесенко І.В.СИСТЕМА ПСИХОТЕРАПЕВТИЧНОЇ КОРЕКЦІЇ СОМАТОГЕННИХ ДЕПРЕСИВНИХ РОЗЛАДІВ У ОСІБ, ЯКІ ПЕРЕНЕСЛИ МОЗКОВИЙ ІНСУЛЬТ.У статті показані результати обстеження 60 пацієнтів, які перенесли мозковий інсульт. Вивчено розвиток соматогенних розладів депресивного спектру у даних осіб протягом року. У гострому періоді мозкового інсульту на перше місце виходили різні порушення свідомості з подальшим приєднанням когнітивних порушень, потім, на тлі виходу пацієнтів з синдрому порушеного свідомості, у них формувалися різні психоемоційні порушення, лідируючу позицію в яких займали соматогенна депресія і тривога. Запропонована нами система психотерапевтичної корекції дозволила знизити частоту і вираженість даних порушень, поліпшити якість життя і соціальне функціонування пацієнтів.Ключові слова: соматогена депресія, психотерапія корекції, мозковий інсульт Михайлов В.Б. , Кожина А.М. , Здесенко И.В.СИСТЕМА ПСИХОТЕРАПЕВТИЧЕСКОЙ КОРРЕКЦИИ СОМАТОГЕННЫХ ДЕПРЕССИВНЫХ РАССТРОЙСТВ У ЛИЦ, ПЕРЕНЕСШИХ МОЗГОВОЙ ИНСУЛЬТВ статье показаны результаты обследования 60 пациентов, перенесших мозговой инсульт. Изучено развитие соматогенных расстройств депрессивного спектра у данных лиц на протяжении года. В остром периоде мозгового инсульта на первое место выходили различные нарушения сознания с последующим присоединением когнитивных нарушений, затем на фоне выхода пациентов из синдрома нарушенного сознания у них формировались различные психоэмоциональные нарушения, лидирующую позицию в которых занимали соматогенная депрессия и тревога. Предложенная нами система психотерапевтической коррекции позволила снизить частоту и выраженность данных нарушений, улучшить качество жизни и социальное функционирование пациентов.Ключевые слова: непсихотические психические расстройства, система психотерапевтической коррекции, мозговой инсульт.

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Between ‘Savage Man’ and ‘Most Faithful Englishman’ Manteo and the Early Anglo-Indian Exchange, 1584–1590

Itinerario ◽

10.1017/s0165115300044545 ◽

2000 ◽

Vol 24 (2) ◽

pp. 146-169 ◽

Cited By ~ 1

Author(s):

Michael Leroy Oberg

Keyword(s):

North Carolina ◽

Chesapeake Bay ◽

One Year ◽

Anglo Indian

In August of 1587 Manteo, an Indian from Croatoan Island, joined a group of English settlers in an attack on the native village of Dasemunkepeuc, located on the coast of present-day North Carolina. These colonists, amongst whom Manteo lived, had landed on Roanoke Island less than a month before, dumped there by a pilot more interested in hunting Spanish prize ships than in carrying colonists to their intended place of settlement along the Chesapeake Bay. The colonists had hoped to re-establish peaceful relations with area natives, and for that reason they relied upon Manteo to act as an interpreter, broker, and intercultural diplomat. The legacy of Anglo-Indian bitterness remaining from Ralph Lane's military settlement, however, which had hastily abandoned the island one year before, was too great for Manteo to overcome. The settlers found themselves that summer in the midst of hostile Indians.

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Some Biological Applications of High Voltage Electron Microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100051505 ◽

1974 ◽

Vol 32 ◽

pp. 298-299

Author(s):

Hans Ris

Keyword(s):

High Voltage ◽

Chromosome Structure ◽

Nerve Fibers ◽

Good Resolution ◽

High Voltage Electron Microscopy ◽

Voltage Electron ◽

University Of Wisconsin ◽

High Voltage Electron ◽

One Year ◽

The University

The High Voltage Electron Microscope Laboratory at the University of Wisconsin has been in operation a little over one year. I would like to give a progress report about our experience with this new technique. The achievement of good resolution with thick specimens has been mainly exploited so far. A cold stage which will allow us to look at frozen specimens and a hydration stage are now being installed in our microscope. This will soon make it possible to study undehydrated specimens, a particularly exciting application of the high voltage microscope.Some of the problems studied at the Madison facility are: Structure of kinetoplast and flagella in trypanosomes (J. Paulin, U. of Georgia); growth cones of nerve fibers (R. Hannah, U. of Georgia Medical School); spiny dendrites in cerebellum of mouse (Scott and Guillery, Anatomy, U. of Wis.); spindle of baker's yeast (Joan Peterson, Madison) spindle of Haemanthus (A. Bajer, U. of Oregon, Eugene) chromosome structure (Hans Ris, U. of Wisconsin, Madison). Dr. Paulin and Dr. Hanna are reporting their work separately at this meeting and I shall therefore not discuss it here.

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Osseointegration interface of calcified bone and endosseous implants

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100130110 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1096-1097

Author(s):

K.E. Krizan ◽

J.E. Laffoon ◽

M.J. Buckley

Keyword(s):

Structure And Function ◽

Titanium Implants ◽

En Bloc ◽

Endosseous Implants ◽

Ultrastructural Studies ◽

The Past ◽

Cacodylate Buffer ◽

One Year ◽

And Function

With increase use of tissue-integrated prostheses in recent years it is a goal to understand what is happening at the interface between haversion bone and bulk metal. This study uses electron microscopy (EM) techniques to establish parameters for osseointegration (structure and function between bone and nonload-carrying implants) in an animal model. In the past the interface has been evaluated extensively with light microscopy methods. Today researchers are using the EM for ultrastructural studies of the bone tissue and implant responses to an in vivo environment. Under general anesthesia nine adult mongrel dogs received three Brånemark (Nobelpharma) 3.75 × 7 mm titanium implants surgical placed in their left zygomatic arch. After a one year healing period the animals were injected with a routine bone marker (oxytetracycline), euthanized and perfused via aortic cannulation with 3% glutaraldehyde in 0.1M cacodylate buffer pH 7.2. Implants were retrieved en bloc, harvest radiographs made (Fig. 1), and routinely embedded in plastic. Tissue and implants were cut into 300 micron thick wafers, longitudinally to the implant with an Isomet saw and diamond wafering blade [Beuhler] until the center of the implant was reached.

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Effectiveness of a 24-hour nicotine patch in conjunction with a cognitive behavioural programme: one year outcome transdermal

Addiction ◽

10.1046/j.1360-0443.1997.921274.x ◽

1997 ◽

Vol 92 (1) ◽

pp. 27-31

Author(s):

Robyn L. Richmond ◽

Linda Kehoe ◽

Abilio Cesar De Almeida Neto

Keyword(s):

Nicotine Patch ◽

Cognitive Behavioural ◽

One Year

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Resources: Internet Resources for the Independent Medical Evaluator – 2007

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2007.julaug02 ◽

2007 ◽

Vol 12 (4) ◽

pp. 4-7

Author(s):

Christopher R. Brigham ◽

Jenny Walker

Keyword(s):

Head Trauma ◽

Clonic Seizure ◽

Acute Subdural Hematoma ◽

Orbital Fracture ◽

Orbital Wall ◽

First Occurrence ◽

One Year ◽

The One ◽

Neurological Injuries ◽

Medial Orbital Wall

Abstract Rating patients with head trauma and multiple neurological injuries can be challenging. The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, Section 13.2, Criteria for Rating Impairment Due to Central Nervous System Disorders, outlines the process to rate impairment due to head trauma. This article summarizes the case of a 57-year-old male security guard who presents with headache, decreased sensation on the left cheek, loss of sense of smell, and problems with memory, among other symptoms. One year ago the patient was assaulted while on the job: his Glasgow Coma Score was 14; he had left periorbital ecchymosis and a 2.5 cm laceration over the left eyelid; a small right temporoparietal acute subdural hematoma; left inferior and medial orbital wall fractures; and, four hours after admission to the hospital, he experienced a generalized tonic-clonic seizure. This patient's impairment must include the following components: single seizure, orbital fracture, infraorbital neuropathy, anosmia, headache, and memory complaints. The article shows how the ratable impairments are combined using the Combining Impairment Ratings section. Because this patient has not experienced any seizures since the first occurrence, according to the AMA Guides he is not experiencing the “episodic neurological impairments” required for disability. Complex cases such as the one presented here highlight the need to use the criteria and estimates that are located in several sections of the AMA Guides.

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