Lack of Association between Monocyte Chemoattractant Protein-1 (MCP-1) Gene Promoter Polymorphism and Behcet’s Disease with and without Ocular Involvement in Iranian Population: A Case–Control Study

Background. Controversy remains for the association between hepatocyte nuclear factor4α(HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.Methods. Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 ofHNF-4αin the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.Results. Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68,P=0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92,P=0.003) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.Conclusions. Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.

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Tumor necrosis factor-α (TNF-α)-308G/A promoter polymorphism in colorectal cancer in ethnic Kashmiri population — A case control study in a detailed perspective

Meta Gene ◽

10.1016/j.mgene.2016.06.001 ◽

2016 ◽

Vol 9 ◽

pp. 128-136 ◽

Cited By ~ 15

Author(s):

Mujeeb Zafar Banday ◽

Henah Mehraj Balkhi ◽

Zeenat Hamid ◽

Aga Syed Sameer ◽

Nissar A. Chowdri ◽

...

Keyword(s):

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Case Control Study ◽

Promoter Polymorphism ◽

Case Control ◽

Tnf Α ◽

Kashmiri Population ◽

Factor Α ◽

Necrosis Factor ◽

Control Study

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DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case–Control Study

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2019.0218 ◽

2020 ◽

Vol 24 (3) ◽

pp. 113-119

Author(s):

Sevda Kurt-Bayrakdar ◽

Ayla Ozturk ◽

Esra Tekcan ◽

Nurten Kara

Keyword(s):

Chronic Periodontitis ◽

Case Control Study ◽

Promoter Polymorphism ◽

Case Control ◽

Control Study

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Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

Analytical Cellular Pathology ◽

10.1155/2015/621893 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Svetla Nikolova ◽

Milka Dikova ◽

Dobrin Dikov ◽

Assen Djerov ◽

Gyulnas Dzhebir ◽

...

Keyword(s):

Idiopathic Scoliosis ◽

Case Control Study ◽

Early Stage ◽

Promoter Polymorphism ◽

Case Control ◽

Chi Squared ◽

Bulgarian Population ◽

Deformity Progression ◽

Curve Severity ◽

Control Study

Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region ofIL-6gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and theIL-6promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of theIL-6genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between theIL-6(-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between theIL-6(-174 G/C) polymorphism and curve severity was detected.IL-6gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.

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Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation

Neurology Research International ◽

10.1155/2014/176535 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6

Author(s):

Yuyun Yueniwati ◽

Valentina Yurina ◽

Mohammad Rasjad Indra

Keyword(s):

Ischemic Stroke ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Promoter Polymorphism ◽

Stroke Patients ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Media Thickness ◽

Pcr Method

Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children. Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT was examined by utilizing high resolution B-mode ultrasound. Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case children. CIMT of case children was significantly different from that of controlled children (0.61±0.012 mm versus,0.52±0.015 mm,P=0.021). Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples.

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