Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis

2022 ◽  
pp. 1-9
Author(s):  
MA Nielsen ◽  
D Køster ◽  
S Greisen ◽  
A Troldborg ◽  
K Stengaard-Pedersen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fibroblast Activation ◽  
Galectin 3

scholarly journals Within-day variation and influence of physical exercise on circulating Galectin-3 in patients with rheumatoid arthritis and healthy individuals

2015 ◽  
Vol 82 (1) ◽  
pp. 70-75 ◽  
Author(s):  
S. F. Issa ◽  
A. F. Christensen ◽  
T. Lottenburger ◽  
K. Junker ◽  
H. Lindegaard ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Exercise ◽  
Healthy Individuals ◽  
Galectin 3

scholarly journals Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis

2016 ◽  
Vol 21 (11) ◽  
pp. 1915-1923 ◽  
Author(s):  
Premarani Sinnathurai ◽  
Wendy Lau ◽  
Ana Julia Vieira de Ribeiro ◽  
William W. Bachovchin ◽  
Helen Englert ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Sclerosis ◽  
Dipeptidyl Peptidase ◽  
Fibroblast Activation Protein ◽  
Dipeptidyl Peptidase 4 ◽  
Fibroblast Activation

scholarly journals Galectin 3 and its binding protein in rheumatoid arthritis

2003 ◽  
Vol 48 (10) ◽  
pp. 2788-2795 ◽  
Author(s):  
Shiro Ohshima ◽  
Stefan Kuchen ◽  
Christian A. Seemayer ◽  
Diego Kyburz ◽  
Astrid Hirt ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Binding Protein ◽  
Galectin 3

scholarly journals Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity

2019 ◽  
Vol 9 ◽  
Author(s):  
Santiago P. Mendez-Huergo ◽  
Pablo F. Hockl ◽  
Juan C. Stupirski ◽  
Sebastián M. Maller ◽  
Luciano G. Morosi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Clinical Relevance ◽  
Differential Regulation ◽  
Galectin 3

scholarly journals Immuno-PET and Immuno-SPECT of Rheumatoid Arthritis with Radiolabeled Anti-Fibroblast Activation Protein Antibody Correlates with Severity of Arthritis

2015 ◽  
Vol 56 (5) ◽  
pp. 778-783 ◽  
Author(s):  
P. Laverman ◽  
T. van der Geest ◽  
S. Y. A. Terry ◽  
D. Gerrits ◽  
B. Walgreen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fibroblast Activation Protein ◽  
Fibroblast Activation

scholarly journals Regression analysis of the interrelation between galectin-3 and factors aggravating chronic heart failure in patients with rheumatoid arthritis

2021 ◽  
pp. 50-58
Author(s):  
A.S. Ankudinov ◽  
◽  
A.N. Kalyagin ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Failure ◽  
Regression Analysis ◽  
Chronic Heart Failure ◽  
Significant Risk ◽  
Significance Level ◽  
X Ray ◽  
Reactive Protein ◽  
Galectin 3 ◽  
Water Salt

Aim of study. To reveal the most significant risk factors of chronic heart failure (CHF) decompensation against the background of rheumatoid arthritis (RA) and to carry out a regression analysis of galectin-3 level. Material and methods. Study group: 134 CHF RA patients; comparison group: 122 CHF patients without RA. The functional CHF class of the study participants was I-II according to the NYHA. The RA diagnosis was established based on X-ray examination and serological testing including determination of the rheumatoid factor, antibodies to the cyclic citrullinated peptide and C-reactive protein. The activity of the inflammatory process was evaluated using the DAS28 index and the visual analogue scale for pain. The X-ray stage of RA was I-III according to Steinbrocker classification in all patients enrolled. The medicines for CHF treatment were comparable in the groups. The disease-modifying anti-rheumatic drug was methotrexate. Patients who did not receive methotrexate due to development of adverse effect and/or individual intolerance were administered 20mg leflunomide per day. Additionally, NSAIDS were used (enteral, parenteral, local application). Haematological, biochemical and instrumental tests were used. The data processing was performed via the STATISTICA 10.0 software; the paper presents statistically reliable results. The significance level was set at p<0.05. Results. As a result, logistic regression analysis revealed statistically significant associations between galectin-3 and the level of atrial natriuretic peptide (r=0.3; beta=0.36; p=0.02), triglycerides (r=0.3; beta=0.6; p=0.04), low-density lipoproteins (r=0.3; beta=0.2; p=0.001) and the glomerular filtration rate (r=0.5; beta=0.3; p=0.01). Conclusion. The analysis has revealed data pointing to the possibility of heart failure compensation against the background of RA at the level of galectin-3 concentration of 17.6ng/ml or higher. The regression model attests to the association between the cytokine levels observed and the possible destabilisation of dyslipidaemia progression, kidney function and water-salt metabolism.

Synovial Fibroblast Activation in Rheumatoid Arthritis

1998 ◽  
Vol 47 (9) ◽  
pp. 355-356
Author(s):  
R. Newton ◽  
E. Mochan
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblast ◽  
Fibroblast Activation

scholarly journals Association of galectin‐3 with markers of myocardial function, atherosclerosis, and vascular fibrosis in patients with rheumatoid arthritis

2018 ◽  
Vol 42 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Panagiota Anyfanti ◽  
Eugenia Gkaliagkousi ◽  
Eleni Gavriilaki ◽  
Areti Triantafyllou ◽  
Panagiotis Dolgyras ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Myocardial Function ◽  
Galectin 3
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