scholarly journals Galectin 3 and its binding protein in rheumatoid arthritis

2003 ◽  
Vol 48 (10) ◽  
pp. 2788-2795 ◽  
Author(s):  
Shiro Ohshima ◽  
Stefan Kuchen ◽  
Christian A. Seemayer ◽  
Diego Kyburz ◽  
Astrid Hirt ◽  
...  
2015 ◽  
Vol 82 (1) ◽  
pp. 70-75 ◽  
Author(s):  
S. F. Issa ◽  
A. F. Christensen ◽  
T. Lottenburger ◽  
K. Junker ◽  
H. Lindegaard ◽  
...  

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Sabine Blaschke ◽  
Kathinka Rinke ◽  
Michael Maring ◽  
Thomas Flad ◽  
Susann Patschan ◽  
...  

Pathology ◽  
2009 ◽  
Vol 41 (3) ◽  
pp. 229-233 ◽  
Author(s):  
Ju-Han Lee ◽  
Xianglan Zhang ◽  
Bong Kyung Shin ◽  
Eung Seok Lee ◽  
Insun Kim

2021 ◽  
Vol 12 ◽  
Author(s):  
Shihan Zhen ◽  
Ruoxin Cai ◽  
Xuelian Yang ◽  
Yanan Ma ◽  
Deliang Wen

BackgroundGalectin-3-binding protein (GAL-3BP) is a ubiquitous and multifunctional secreted glycoprotein, which functions in innate immunity and has been highlighted as a potential mediator of adipose inflammation in obesity. In this study, we aimed to identify whether GAL-3BP is a novel biological marker for metabolic syndrome (MetS).MethodsThe biochemical and anthropometric variables of the 570 participants in this study were evaluated using standard procedures. Their serum GAL-3BP levels were measured using enzyme-linked immunosorbent assay (ELISA), while the association between the glycoprotein and MetS was analyzed using multiple logistic regression analyses. Moreover, an experimental MetS model was established. The expression of GAL-3BP in serum and adipose tissue was measured using ELISA and western blotting. Lipid accumulation was determined with the use of immunohistochemistry and immunofluorescent staining.ResultsThe serum GAL-3BP level was found to be positively associated with MetS. The logistic regression analyses demonstrated that participants expressing the upper levels of GAL-3BP were more likely to develop MetS than those expressing less of the glycoprotein (OR = 2.39, 95%CI: 1.49, 3.83). The association between the serum GAL-3BP level and MetS was found preferentially in postmenopausal women (OR = 2.30, 95%CI: 1.31, 4.05). In addition, GAL-3BP was increased in the serum and visceral adipose tissue (VAT) of high fat diet (HFD) mice. Moreover, GAL-3BP was highly expressed in VAT macrophages.ConclusionsThis study confirmed serum GAL-3BP to be positively associated with MetS, highlighting it as a useful biological marker of MetS in Chinese participants.


Author(s):  
MA Nielsen ◽  
D Køster ◽  
S Greisen ◽  
A Troldborg ◽  
K Stengaard-Pedersen ◽  
...  

2020 ◽  
Vol 4 (2) ◽  
pp. 106
Author(s):  
RadwaM Fath Allah ◽  
KhalidaE El-Refaei ◽  
EnayatE Osman ◽  
Seham Sabry ◽  
ImanM Elbagoury

2019 ◽  
Vol 86 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Yanlin Wei ◽  
Nannan Xia ◽  
Weifeng Zhang ◽  
Jiashu Huang ◽  
Zhijuan Ren ◽  
...  

2019 ◽  
Vol 36 (2) ◽  
pp. 177-183
Author(s):  
Ibrahim Halil Yavuz ◽  
Goknur Ozaydin-Yavuz ◽  
Erdem Çokluk ◽  
Zehra Kurtoğlu ◽  
Serap Gunes Bilgili

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