Typical Prenatal Vitamin D Supplement Intake Does Not Prevent Decrease of Plasma 25-Hydroxyvitamin D at Birth

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

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Development and validation of an interview-administered FFQ for assessment of vitamin D and calcium intakes in Finnish women

British Journal Of Nutrition ◽

10.1017/s0007114515005474 ◽

2016 ◽

Vol 115 (6) ◽

pp. 1100-1107 ◽

Cited By ~ 8

Author(s):

Suvi T. Itkonen ◽

Maijaliisa Erkkola ◽

Essi Skaffari ◽

Pilvi Saaristo ◽

Elisa M. Saarnio ◽

...

Keyword(s):

Vitamin D ◽

Food Groups ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Food Records ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D ◽

Mean Differences ◽

Development And Validation ◽

Supplement Intake

AbstractIncreased vitamin D fortification of dairy products has increased the supply of vitamin D-containing products with different vitamin D contents on the market in Finland. The authors developed a ninety-eight-item FFQ with eight food groups and with a question on supplementation to assess dietary and supplemental vitamin D and Ca intakes in Finnish women (60ºN). The FFQ was validated in subgroups with different habitual vitamin D supplement use (0–57·5 µg/d) against the biomarker serum 25-hydroxyvitamin D (S-25(OH)D) and against 3-d food records (FR) (n29–67). Median total vitamin D intake among participants was 9·4 (range 1·6–30·5) µg/d. Spearman’s correlations for vitamin D and Ca ranged from 0·28 (P0·146, FFQv. S-25(OH)D, persons not using supplements) to 0·75 (P<0·001, FFQv. FR, supplement use included). The correlations between the FFQ and S-25(OH)D concentrations improved within increasing supplement intake. The Bland–Altman analysis showed wide limits of agreement between FFQ and FR: for vitamin D between −7·8 and 8·8 µg/d and for Ca between −938 and 934 mg/d, with mean differences being 0·5 µg/d and 2 mg/d, respectively. The triads method was used to calculate the validity coefficients of the FFQ for vitamin D, resulting in a mean of 1·00 (95 % CI 0·59, 1·00) and a range from 0·33 to 1·00. The perceived variation in the estimates could have been avoided with a longer FR period and larger number of participants. The results are comparable with earlier studies, and the FFQ provides a reasonable estimation of vitamin D and Ca intakes.

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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients ◽

10.3390/nu12092742 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2742 ◽

Cited By ~ 1

Author(s):

Sarah Hakeem ◽

Nuno Mendonca ◽

Terry Aspray ◽

Andrew Kingston ◽

Carmen Ruiz-Martin ◽

...

Keyword(s):

Vitamin D ◽

Cognitive Status ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Major Predictor ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

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Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model

Medicina ◽

10.3390/medicina55060265 ◽

2019 ◽

Vol 55 (6) ◽

pp. 265 ◽

Cited By ~ 1

Author(s):

Egidijus Šimoliūnas ◽

Ieva Rinkūnaitė ◽

Živilė Bukelskienė ◽

Virginija Bukelskienė

Keyword(s):

Vitamin D ◽

Vitamin D3 ◽

Delivery Systems ◽

Oral Vitamin ◽

Medical Testing ◽

Laboratory Rats ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Oral Supplements ◽

Vitamin D Supplement

Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second—oil-based vitamin D3, and the third—micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days). Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.

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Vitamin D deficiency prevalence and risk factors among pregnant Chinese women

Public Health Nutrition ◽

10.1017/s1368980015002980 ◽

2015 ◽

Vol 20 (10) ◽

pp. 1746-1754 ◽

Cited By ~ 18

Author(s):

Chunfeng Yun ◽

Jing Chen ◽

Yuna He ◽

Deqian Mao ◽

Rui Wang ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Chinese Women ◽

Sun Exposure ◽

Regression Analyses ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

AbstractObjectiveTo evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.DesignA descriptive cross-sectional analysis.SettingChina National Nutrition and Health Survey (CNNHS) 2010–2013.SubjectsA total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007).ConclusionsVitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.

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Effects of Moderate Sun Exposure and Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentration Among Malay Women

Current Developments in Nutrition ◽

10.1093/cdn/nzab059_005 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 1304-1304

Author(s):

Norliyana Aris ◽

Hamid Jan Bin Jan Mohamed ◽

Wan Mohd Izani Bin Wan Mohamed

Keyword(s):

Vitamin D ◽

Placebo Group ◽

Vitamin D Deficiency ◽

Sun Exposure ◽

Vitamin D Supplementation ◽

Dietary Vitamin ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Hands And Feet ◽

Vitamin D Supplement

Abstract Objectives Known as ‘sunshine vitamin’, sun exposure is a major and natural source of vitamin D. This study aimed to investigate the effects of moderate sun exposure and vitamin D supplementation on vitamin D concentration among Malay women in Kelantan, Malaysia. Methods A quasi-experimental study design was carried out among female indoor workers with vitamin D deficiency (serum 25-hydroxyvitamin D < 50 nmol/l) for 12 weeks to evaluate the effects of moderate sun exposure (n = 19; 15 minutes sun exposure biweekly on face, lower arms, hands and feet), vitamin D supplementation (n = 15; 50 000 IU cholecalciferol weekly) and placebo (n = 15) on serum 25-hydroxyvitamin D (25(OH)D) levels. Data was collected twice from each respondent, firstly during baseline and secondly during endpoint. Body composition measurements (body fat percentage and body mass index), fasting blood test (serum 25(OH)D level) and questionnaire (socio-demographic, physical activity and dietary vitamin D intake) were conducted. The vitamin D classification was based on the 2011 Endocrine Society Clinical Practice Guidelines. Repeated measure ANOVA within group analysis was applied. Results The baseline characteristics did not differ significantly among study groups except for age (F = 6.15, p = 0.004). After 12 weeks, serum 25(OH)D levels increased significantly in sun exposure (mean difference (MD) = 14.27 nmol/l, p < 0.001) and vitamin D supplement group (MD = 14.30 nmol/l, p < 0.001) but not in the placebo group (MD = 1.63 nmol/l, p = 0.067). Conclusions The 12-weeks intervention with moderate sun exposure and vitamin D supplementation showed a similar significant increment in serum 25(OH)D levels. However, no changes in serum 25(OH)D was observed in the placebo group. These results showed that sunlight exposure and vitamin D supplement were equally helpful in improving serum 25(OH)D levels in participants with vitamin D deficiency. Funding Sources Short Term Research Grant, Universiti Sains Malaysia.

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Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study

Respiratory Medicine ◽

10.1016/j.rmed.2018.01.017 ◽

2018 ◽

Vol 136 ◽

pp. 65-70 ◽

Cited By ~ 5

Author(s):

Ben M. Brumpton ◽

Arnulf Langhammer ◽

Anne H. Henriksen ◽

Pål R. Romundstad ◽

Yue Chen ◽

...

Keyword(s):

Vitamin D ◽

Asthma Control ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Hunt Study ◽

Vitamin D Supplement

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Vitamin D Status and Supplementation in Elite Irish Athletes

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.23.5.441 ◽

2013 ◽

Vol 23 (5) ◽

pp. 441-448 ◽

Cited By ~ 17

Author(s):

Pamela J. Magee ◽

L. Kirsty Pourshahidi ◽

Julie M. W. Wallace ◽

John Cleary ◽

Joe Conway ◽

...

Keyword(s):

Vitamin D ◽

Biochemical Analysis ◽

Vitamin D Insufficiency ◽

Early Spring ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

High Prevalence ◽

25 Hydroxyvitamin D ◽

And Training ◽

Vitamin D Supplement

Background:A high prevalence of vitamin D insufficiency/deficiency, which may impact on health and training ability, is evident among athletes worldwide. This observational study investigated the vitamin D status of elite Irish athletes and determined the effect of wintertime supplementation on status.Methods:Serum 25-hydroxyvitamin D [25(OH)D], calcium, and plasma parathyroid hormone were analyzed in elite athletes in November 2010 (17 boxers, 33 paralympians) or March 2011 (34 Gaelic Athletic Association [GAA] players). A subset of boxers and paralympians (n = 27) were supplemented during the winter months with either 5,000 IU vitamin D3/d for 10–12 weeks or 50,000 IU on one or two occasions. Biochemical analysis was repeated following supplementation.Results:Median 25(OH)D of all athletes at baseline was 48.4 nmol/L. Vitamin D insufficiency/deficiency (serum 25(OH)D <50 nmol/L) was particularly evident among GAA players (94%) due to month of sampling. Wintertime supplementation (all doses) significantly increased 25(OH)D (median 62.8 nmol/L at baseline vs. 71.1 nmol/L in April or May; p = .001) and corrected any insufficiencies/deficiencies in this subset of athletes. In contrast, 25(OH)D significantly decreased in those that did not receive a vitamin D supplement, with 74% of athletes classed as vitamin D insufficient/deficient after winter, compared with only 35% at baseline.Conclusions:This study has highlighted a high prevalence of vitamin D insufficiency/deficiency among elite Irish athletes and demonstrated that wintertime vitamin D3 supplementation is an appropriate regimen to ensure vitamin D sufficiency in athletes during winter and early spring.

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