Development and validation of an interview-administered FFQ for assessment of vitamin D and calcium intakes in Finnish women

AbstractIncreased vitamin D fortification of dairy products has increased the supply of vitamin D-containing products with different vitamin D contents on the market in Finland. The authors developed a ninety-eight-item FFQ with eight food groups and with a question on supplementation to assess dietary and supplemental vitamin D and Ca intakes in Finnish women (60ºN). The FFQ was validated in subgroups with different habitual vitamin D supplement use (0–57·5 µg/d) against the biomarker serum 25-hydroxyvitamin D (S-25(OH)D) and against 3-d food records (FR) (n29–67). Median total vitamin D intake among participants was 9·4 (range 1·6–30·5) µg/d. Spearman’s correlations for vitamin D and Ca ranged from 0·28 (P0·146, FFQv. S-25(OH)D, persons not using supplements) to 0·75 (P<0·001, FFQv. FR, supplement use included). The correlations between the FFQ and S-25(OH)D concentrations improved within increasing supplement intake. The Bland–Altman analysis showed wide limits of agreement between FFQ and FR: for vitamin D between −7·8 and 8·8 µg/d and for Ca between −938 and 934 mg/d, with mean differences being 0·5 µg/d and 2 mg/d, respectively. The triads method was used to calculate the validity coefficients of the FFQ for vitamin D, resulting in a mean of 1·00 (95 % CI 0·59, 1·00) and a range from 0·33 to 1·00. The perceived variation in the estimates could have been avoided with a longer FR period and larger number of participants. The results are comparable with earlier studies, and the FFQ provides a reasonable estimation of vitamin D and Ca intakes.

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Vitamin D Status and Seasonal Variation among Danish Children and Adults: A Descriptive Study

Nutrients ◽

10.3390/nu10111801 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1801 ◽

Cited By ~ 20

Author(s):

Louise Hansen ◽

Anne Tjønneland ◽

Brian Køster ◽

Christine Brot ◽

Rikke Andersen ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variation ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Wide Range ◽

Adults And Children ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement ◽

Very High

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

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Bone mineral content and serum 25-hydroxyvitamin D concentration in breast-fed infants with and without supplemental vitamin D

The Journal of Pediatrics ◽

10.1016/s0022-3476(81)80827-x ◽

1981 ◽

Vol 98 (5) ◽

pp. 696-701 ◽

Cited By ~ 66

Author(s):

Frank R. Greer ◽

John E. Searcy ◽

Ronald S. Levin ◽

Jean J. Steichen ◽

Paule Steichen Asch ◽

...

Keyword(s):

Vitamin D ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Hydroxyvitamin D ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D ◽

Breast Fed

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Typical Prenatal Vitamin D Supplement Intake Does Not Prevent Decrease of Plasma 25-Hydroxyvitamin D at Birth

Journal of the American College of Nutrition ◽

10.1080/07315724.2013.879843 ◽

2014 ◽

Vol 33 (5) ◽

pp. 394-399 ◽

Cited By ~ 5

Author(s):

Marlies K. Ozias ◽

Elizabeth H. Kerling ◽

Danielle N. Christifano ◽

Susan A. Scholtz ◽

John Colombo ◽

...

Keyword(s):

Vitamin D ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement ◽

Supplement Intake

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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Nutrients ◽

10.3390/nu12092742 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2742 ◽

Cited By ~ 1

Author(s):

Sarah Hakeem ◽

Nuno Mendonca ◽

Terry Aspray ◽

Andrew Kingston ◽

Carmen Ruiz-Martin ◽

...

Keyword(s):

Vitamin D ◽

Cognitive Status ◽

Vitamin D Status ◽

Very Old ◽

Old Adults ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Major Predictor ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.

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Soluble TNF Receptors are Modulated by Vitamin D Status but not by Acute Perturbations in 25-Hydroxyvitamin D Following A Bolus of Supplemental Vitamin D

Journal of Cytokine Biology ◽

10.4172/2576-3881.1000118 ◽

2017 ◽

Vol 02 (02) ◽

Cited By ~ 1

Author(s):

Tyler Barker ◽

Kimberly B Brown ◽

Victoria E Rogers

Keyword(s):

Vitamin D ◽

Vitamin D Status ◽

Tnf Receptors ◽

Hydroxyvitamin D ◽

Soluble Tnf Receptors ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D

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Vitamin D deficiency prevalence and risk factors among pregnant Chinese women

Public Health Nutrition ◽

10.1017/s1368980015002980 ◽

2015 ◽

Vol 20 (10) ◽

pp. 1746-1754 ◽

Cited By ~ 18

Author(s):

Chunfeng Yun ◽

Jing Chen ◽

Yuna He ◽

Deqian Mao ◽

Rui Wang ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Chinese Women ◽

Sun Exposure ◽

Regression Analyses ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplement

AbstractObjectiveTo evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.DesignA descriptive cross-sectional analysis.SettingChina National Nutrition and Health Survey (CNNHS) 2010–2013.SubjectsA total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007).ConclusionsVitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.

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Vitamin D in pregnancy at high latitude in Scotland

British Journal Of Nutrition ◽

10.1017/s0007114512002255 ◽

2012 ◽

Vol 109 (5) ◽

pp. 898-905 ◽

Cited By ~ 27

Author(s):

Paul Haggarty ◽

Doris M. Campbell ◽

Susan Knox ◽

Graham W. Horgan ◽

Gwen Hoad ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

High Latitude ◽

Maternity Hospital ◽

Hydroxyvitamin D ◽

Supplement Use ◽

The North ◽

25 Hydroxyvitamin D ◽

Vitamin D Supplements ◽

In Pregnancy

The aims of the present study were to determine compliance with current advice on vitamin D and to assess the influence of season, dietary intake, supplement use and deprivation on vitamin D status in pregnant mothers and newborns in the north of Scotland where sunlight exposure is low. Pregnant women (n 1205) and their singleton newborns were studied in the Aberdeen Maternity Hospital (latitude 57°N) between 2000 and 2006. Plasma 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 were measured at 19 weeks of gestation in mothers and at delivery in newborns. During pregnancy, 21·0 (95 % CI 18·5, 23·5) % of women took vitamin D supplements. The median intake was 5 μg/d and only 0·6 (95 % CI 0·1, 1·0) % took the recommended 10 μg/d. Supplement use, adjusted for season, dietary intake and deprivation, significantly increased maternal 25-hydroxyvitamin D (25(OH)D) by 10·5 (95 % CI 5·7, 15·2) nmol/l (P< 0·001); however, there was no significant effect on cord 25(OH)D (1·4 (95 % CI − 1·8, 4·5) nmol/l). The biggest influence on both maternal and cord 25(OH)D was season of birth (P< 0·001). Compared with the least deprived women (top three deciles), the most deprived pregnancies (bottom three deciles) were characterised by a significantly lower seasonally adjusted 25(OH)D ( − 11·6 (95 % CI − 7·5, − 15·7) nmol/l in the mother and − 5·8 (95 % CI − 2·3, − 9·4) nmol/l in the cord), and a lower level of supplement use (10 (95 % CI 4, 17) v. 23 (95 % CI 20, 26) %). More should be done to promote vitamin D supplement use in pregnancy but the critical importance of endogenous vitamin D synthesis, and known adaptations of fat metabolism specific to pregnancy, suggest that safe sun advice may be a useful additional strategy, even at high latitude.

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Population vitamin D stores are increasing in Tasmania and this is associated with less BMD loss over 10 years

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab197 ◽

2021 ◽

Author(s):

Michael Thompson ◽

Dawn Aitken ◽

Saliu Balogun ◽

Flavia Cicuttini ◽

Graeme Jones

Keyword(s):

Vitamin D ◽

Lumbar Spine ◽

Vitamin D Deficiency ◽

Cohort Analysis ◽

Sun Exposure ◽

Community Dwelling ◽

Longitudinal Change ◽

Hydroxyvitamin D ◽

Supplement Use ◽

25 Hydroxyvitamin D

Abstract Introduction Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health. There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25(OH)D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status. Methods Prospective cohort analysis of community-dwelling adults aged 50-80 years who had 25(OH)D assessed by radioimmunoassay and BMD by DXA at baseline (n=1096), 2.5 (n=870) and 10 (n=565) years. Sun exposure was quantified by questionnaire and supplement use at clinic review. 25(OH)D <50nmol/L was considered deficient. Participants were provided with their 25(OH)D results. Results Over 10 years 25(OH)D increased (52.2 ± 17.0 to 63.5 ± 23.6 nmol/L, p<0.001). Participants with baseline deficiency had larger 25(OH)D increases than baseline sufficient participants (19.2 ± 25.3 vs 1.6 ± 23.3 nmol/L, p<0.001). Longitudinal change in 25(OH)D was associated with baseline summer (β=1.46, p<0.001) and winter (β=1.29, p=0.003) sun exposure, change in summer (β=1.27, p=0.002) and winter (β=1.47, p<0.001) sun exposure and vitamin D supplement use (β=25.0 – 33.0, p<0.001). Persistent vitamin D sufficiency was associated with less BMD loss at the femoral neck (β=0.020, p=0.027), lumbar spine (β=0.033, p=0.003) and total hip (β=0.023, p=0.021) compared to persistent vitamin D deficiency. Achieving vitamin D sufficiency was associated with less BMD loss at the lumbar spine (β=0.045, p<0.001) compared to persistent vitamin D deficiency. Conclusions Population 25(OH)D concentration increased due to a combination of increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency was associated with less BMD loss over 10 years.

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Factors Associated with Vitamin D Deficiency and Inadequacy among Women of Childbearing Age in the United States

ISRN Obstetrics and Gynecology ◽

10.5402/2012/691486 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 16

Author(s):

Guixiang Zhao ◽

Earl S. Ford ◽

James Tsai ◽

Chaoyang Li ◽

Janet B. Croft

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

The United States ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Hydroxyvitamin D ◽

Supplement Use ◽

Increased Risk ◽

25 Hydroxyvitamin D ◽

Dietary Supplement Use

Objective. To examine the prevalence and correlates of vitamin D deficiency and inadequacy among US women of childbearing age. Methods. Data from 1,814 female participants (20–44 y) in the 2003–2006 NHANES were analyzed to estimate the age-adjusted prevalence and prevalence ratios with 95% confidence intervals (CIs) for vitamin D deficiency (defined as serum 25-hydroxyvitamin D [25(OH)D] <12.0 ng/mL) and inadequacy (defined as 25(OH)D: 12.0–<20.0 ng/mL). Results. The age-adjusted prevalence was 11.1% (95% CI: 8.8–14.0%) for vitamin D deficiency and 25.7% (95% CI: 22.3–29.5%) for vitamin D inadequacy. Race/ethnicity other than non-Hispanic white and obesity were associated with increased risks, whereas dietary supplement use, milk consumption of ≥1 time/day, and potential sunlight exposure during May-October were associated with decreased risks for both vitamin D deficiency and inadequacy (). Current smoking and having histories of diabetes and cardiovascular disease were also associated with an increased risk for vitamin D deficiency (). Conclusions. Among women of childbearing age, periconceptional intervention programs may focus on multiple risk factors for vitamin D deficiency and inadequacy to ultimately improve their vitamin D nutrition.

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